Evaluation of Ingenol mebutate efficacy for the treatment of actinic keratosis with Antera 3D camera

OBJECTIVE: Cumulative exposure of the skin to ultraviolet radiation promotes mutation in keratinocytes and their abnormal growth led to the formation of scaly lesions, called actinic keratoses (AKs). Its incidence is growing at an emerging rate, becoming a worldwide problem especially for occupational ultraviolet (UV) rays exposure. Detectable lesions are often associated with field changes, where the surrounding skin is altered and subclinical lesions may be present. Thus, a field-directed therapy, such as topical treatment, should be preferred for the prevention of invasive cancer development. A retrospective analysis was made, evaluating the efficacy of ingenol-mebutate gel, using a novel device the 3D in vivo optical skin Imaging (Antera 3D, Miravex, Ireland). PATIENTS AND METHODS: We included all patients with multiple non-hypertrophic Aks, to whom it was prescribed ingenol-mebutate gel, applied at the dosages of 0.015 for lesions in the scalp/face (for 3 consecutive days) and at the dosage of 0.05% for lesions in the trunk and/or extremities (for 2 consecutive days). RESULTS: A reduction of the lesions and of median hemoglobin levels, after a follow-up of 60 days, was observed in 100% of patients. CONCLUSIONS: Ingenol mebutate gel, the last topical molecule appeared in the Italian market showed its efficacy using Antera 3D also in terms of hemoglobin reduction. Therefore, this camera could be considered an useful tool for the identification of the area to be treated and for therapeutic follow-up

VHCF response of AM materials: A literature review

The present paper is an overview of the recent experimental results on the Very High Cycle Fatigue (VHCF) response of materials produced through additive manufacturing (AM) processes. At present, VHCF tests have been carried out on AlSi12, AlSi10Mg, and Ti6Al4V specimens produced through AM processes (SLM and EBM). The VHCF strength and the main findings provided in the literature are analyzed in the paper, focusing on the main factors that affect the fatigue response

Capillaroscopy in 2016 : new perspectives in systemic sclerosis

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc. The best method to evaluate vascular injury is nailfold videocapillaroscopy, which detects peripheral capillary morphology, and classifies and scores the abnormalities into different patterns of microangiopathy. Microangiopathy appears to be the best evaluable predictor of the disease development and has been observed to precede the other symptoms by many years. Peripheral blood perfusion is also impaired in SSc, and there are different methods to assess it: laser Doppler and laser speckle techniques, thermography and other emerging techniques

Effect of defect size on P-S-N curves in Very-High-Cycle Fatigue

It is well-known that internal defects play a key role in the Very-High-Cycle Fatigue (VHCF) response of metallic materials. VHCF failures generally nucleate from internal defects, whose size strongly affects the material strength and life. Therefore, S-N curves in the VHCF regime are defect size dependent and the scatter of fatigue data is significantly influenced by the statistical distribution of the defect size within the material. The present paper proposes an innovative approach for the statistical modeling of Probabilistic-S-N (P-S-N) curves in the VHCF regime. The proposed model considers conditional P-S-N curves that depend on a specific value of the initial defect size. From the statistical distribution of the initial defect size, marginal P-S-N curves are estimated and the effect of the risk-volume on the VHCF response is also modeled. Finally, the paper reports a numerical example that quantitatively illustrates the concepts of conditional and marginal P-S-N curves and that shows the effect of the risk-volume on the VHCF response

Residual properties in damaged laminated composites through nondestructive testing: A review

The development of damage tolerance strategies in the design of composite structures constitutes a major challenge for the widespread application of composite materials. Damage tolerance approaches require a proper combination of material behavior description and nondestructive techniques. In contrast to metals, strength degradation approaches, i.e., the residual strength in pres-ence of cracks, are not straightforwardly enforceable in composites. The nonhomogeneous nature of such materials gives rise to several failure mechanisms and, therefore, the definition of an ulti-mate load carrying capacity is ambiguous. Nondestructive techniques are thus increasingly re-quired, where the damage severity is quantified not only in terms of damage extension, but also in terms of material response of the damaged region. Based on different approaches, many nonde-structive techniques have been proposed in the literature, which are able to provide a quantitative description of the material state. In the present paper, a review of such nondestructive techniques for laminated composites is presented. The main objective is to analyze the damage indexes related to each method and to point out their significance with respect to the residual mechanical perfor-mances, as a result of the working principle of each retained technique. A possible guide for future research on this subject is thus outlined

Assessment of treatment effects on digital ulcer and blood perfusion by laser speckle contrast analysis in a patient affected by systemic sclerosis

Laser speckle contrast analysis (LASCA) is a good tool to evaluate the variation in peripheral blood perfu-sion during long-term follow-up andis able to safely monitor digital ulcer evolution inscleroderma patients. It evaluates blood perfusion in different areas within the skin lesions and surrounding them during standard treatment