Present status and future prospects to safeguard Nepali citrus industry against Chinese citrus fly (Bactrocera minax Enderlein)

Unlike other Tephrid flies, the Chinese citrus fly (Bactrocera minax Enderlein) is univoltine and oligophagous species strictly restricted to citrus fruits. It has been a serious threat to the citrus industry in China, Bhutan, India and Nepal causing up to 100% of fruit drop before the harvest. Citrus groves, especially tight-skinned cultivars, sweet orange (Citrus sinensis L. Osbeck) in mid-hill districts like Ramechhap, Sindhuli, Dolakha, Kavre, Syangja, Gulmi, etc. have been threatened while in some pockets, lemon, acid lime, and mandarin have vanished due to the Chinese citrus fly (CCF). The driver behind the spread of this invasive pest seems to be poor research works on the phenology of the pest, ill-equipped management practices, flying nature of adult fly and easy movement of infested fruits. Therefore, with reviewing published data, this study aimed to figure out the most appropriate management technology for curbing the CCF and make comprehensive material for safeguarding the citrus industry in the future. Since Area-Wide Integrated Pest Management (AW-IPM) or Area-Wide Control Program (AWCP) was found to be an effective tool to control the CCF, individual practices are crucial to incorporate. Monitoring the pest with the lure of protein hydrolase (PH) and subsequently killing adults with attractive protein baits of 25% hydrolyzed protein + insecticide as lethal dinner is mentioned exceptionally better. In AWCP domestic practice: orchard sanitation is not so effective if the orchards are sloppy while shallow tillage adds less to the natural enemy mechanism of CCF pupae in the soil. Equally, we conclude that Sterile Insect Technology (SIT) is not so economical and the boons of natural enemies, parasitoid and entomo-pathogens against CCF, is yet to be exploited

Hydro-Climatic Variability in the Karnali River Basin of Nepal Himalaya

Global climate change has local implications. Focusing on datasets from the topographically-challenging Karnali river basin in Western Nepal, this research provides an overview of hydro-climatic parameters that have been observed during 1981–2012. The spatial and temporal variability of temperature and precipitation were analyzed in the basin considering the seven available climate stations and 20 precipitation stations distributed in the basin. The non-parametric Mann–Kendall test and Sen’s method were used to study the trends in climate data. Results show that the average precipitation in the basin is heterogeneous, and more of the stations trend are decreasing. The precipitation shows decreasing trend by 4.91 mm/year, i.e., around 10% on average. Though the increasing trends were observed in both minimum and maximum temperature, maximum temperature trend is higher than the minimum temperature and the maximum temperature trend during the pre-monsoon season is significantly higher (0.08 °C/year). River discharge and precipitation observations were analyzed to understand the rainfall-runoff relationship. The peak discharge (August) is found to be a month late than the peak precipitation (July) over the basin. Although the annual precipitation in most of the stations shows a decreasing trend, there is constant river discharge during the period 1981–2010

Correction: Khatiwada, K.R.; et al. Hydro-Climatic Variability in the Karnali River Basin of Nepal Himalaya. Climate 2016, 4, 17

The authors wish to make the following correction to this paper [...

Study of Adverse Drug Reaction of Anti-Depressants in Adult Patients: A Nepalese Perspective

Background of the study: Depression is a prevalent mental disorder characterized by various symptoms, including low mood, lack of pleasure, changes in appetite and sleep, and difficulty concentrating. Antidepressants are commonly used to manage depression as well as other related disorders, such as anxiety and somatoform disorders. This study aimed to investigate the adverse drug effects experienced by adult patients who were using antidepressants at Chitwan Medical College Teaching Hospital in Nepal. Methods: This study was a retro-prospective, observational study consisting of 117 adult patients under antidepressant medication. The adverse drug profile for the patients was collected using an antidepressant side effect checklist developed by the NHS foundation trust. Statistical analysis was performed using SPSS version 20. Result: The study group consisted of adult patients using antidepressants at Chitwan Medical College Teaching Hospital, Chitwan, Nepal. The mean age of the group was 40.9 ± 12.8, with 63.2% females and 36.7% males. The most common conditions for which antidepressants were prescribed were depression (49.5%), anxiety disorder (31.6%), and somatoform disorder (13.6%). Amitriptyline was the most commonly used medication in monotherapy (64.1%), followed by escitalopram and sertraline. Dry mouth, weight gain, drowsiness, blurred vision, problems with sexual function, and an increase in appetite were the most commonly reported adverse effects. The incidence of certain adverse effects was higher in the multiple therapy group than in the monotherapy group (p Conclusion: The incidence of adverse drug effects is high in patients taking antidepressants, especially those receiving multiple medications. Educating patients about common side effects and prescribing monotherapy whenever possible are crucial in reducing the incidence

Increasing risk of cascading hazards in the central Himalayas

Cascading hazards are becoming more prevalent in the central Himalayas. Primary hazards (e.g., earthquakes, avalanches, and landslides) often trigger secondary hazards (e.g., landslide dam, debris flow, and flooding), compounding the risks to human settlements, infrastructures, and ecosystems. Risk management strategies are commonly tailored to a single hazard, leaving human and natural systems vulnerable to cascading hazards. In this commentary, we characterize diverse natural hazards in the central Himalayas, including their cascading mechanisms and potential impacts. A scientifically sound understanding of the cascading hazards, underlying mechanisms, and appropriate tools to account for the compounding risks are crucial to informing the design of risk management strategies. We also discuss the need for an integrated modeling framework, reliable prediction and early warning system, and sustainable disaster mitigation and adaptation strategies

Percentage of HCV genotype-frequencies.

<p>Percentage of HCV genotype-frequencies.</p

HCV-genotypes stratified by gender and region.

<p>M: male, F: female, “undef” = undefined, n = 200. Gender difference for GT1 vs. 3 non-significant χ²-p = 0.34. Regional difference for GT1 vs. 3 non-significant χ²-p = 0.38.</p><p>HCV-genotypes stratified by gender and region.</p

Phylogenetic tree of the 5 UTR region of HCV.

<p>The tree is generated by the neighbour-joining method in MEGA 6. The symbol indicates the reference sequences. The first character of the code indicates the origin of the sample (K: Kathmandu, L: Lalitpur, (Central Region), B: Biratnagar (Eastern Region), and N: Nepalgunj (Western Region).</p

I28B SNP rs12979860 and rs8099917.

<p>N = 122</p><p>I28B SNP rs12979860 and rs8099917.</p

HCV-RNA positivity stratified by age.

<p>Rate of HCV-infection is associated with age (χ²-p<0.001, error bars show 95% CI).</p