Passiv damping on spacecraft sandwich panels

For reusable and expendable launch vehicles as well as for other spacecraft structural vibration loads are safety critical design drivers impacting mass and lifetime. Here, the improvement of reliability and safety, the reduction of mass, the extension of service life, as well as the reduction of cost for manufacturing are desired. Spacecraft structural design in general is a compromise between lightweight design and robustness with regard to dynamic loads. The structural stresses and strains due to displacements caused by dynamic loads can be reduced by mechanical damping based on passive or active measures. Passive damping systems can be relatively simple and yet are capable of suppressing a wide range of mechanical vibrations. Concepts are low priced in development, manufacturing and application as well as maintenancefree. Compared to active damping measures passive elements do not require electronics, control algorithms, power, actuators, sensors as well as complex maintenance. Moreover, a reliable application of active dampers for higher temperatures and short response times (e. g. re-entry environment) is questionable. The physical effect of passive dampers is based on the dissipation of load induced energy. Recent activities performed by OHB have shown the function of a passive friction-damping device for a vertical tail model of the German X-vehicle PHÖNIX but also for general sandwich structures. The present paper shows brand new results from a corresponding ESA-funded activity where passive damping elements are placed between the face sheets of large spacecraft relevant composite sandwich panels to demonstrate dynamic load reduction in vibration experiments on a shaker. Several passive damping measures are investigated and compared

Reduced Order Modeling of Mistuned Bladed Disks under Rotation

In this paper, a substructure-based reduced order model for mistuned bladed disks is extended to account for the effect of rotational-dependent dynamic properties. To reduce the overall size of the structural model, successive transformations to reduced modal subspaces of smaller dimension are performed by means of a fixed-interface Component Mode Synthesis, a Wave-Based Substructuring, and a Secondary Modal Truncation. Since the threedimensionally shaped rotor blades tend to untwist under the influence of centrifugal forces, the modal reduction bases may undergo significant changes for different speeds of rotation. To prevent the necessity of identifying individual modal subspaces for each operating point and a repetitious passing through the full reduction process, a multi-model formulation is used to obtain a parameterized reduced order model in terms of rotational speed. The accuracy of this approach is assessed by comparison with full finite element models for various steady operating conditions. In terms of computational solution time, the proposed approach outperforms the finite element calculation by 90%. Finally, numerical results are presented addressing the mitigating influence of constant and variable rotational speeds on the amplitude amplification of mistuned bladed disks

Forced response of turbine bladings with alternating mistuning and friction damper coupling

Alternating mistuning of blades can help to avoid aerodynamic instabilities of turbine bladings. The influence of this type of intentional mistuning on the design of friction dampers has hardly been explored so far. To investigate the dynamics of alternately istuned and nonlinearly coupled bladed disks a simple model is set up. The structure is represented by a plane lumped mass cyclic sector model with a single DOF oscillator for each blade. Underplatform dampers, referred to as friction dampers, are considered in terms of separate rigid bodies. Contact forces are evaluated by a penalty-based point contact model. Forced response functions and damper optimization curves are computed and show the potential of improved friction damping performance due to mistuning

Current status of arsenic contamination in drinkingwater and treatment practice in some rural areas of West Bengal, India

The aim of the present investigation was to draw the current scenario of arsenic (As) contamination in drinking water of community tube well and drinking water treated by tube wells installed with different adsorbent media-based treatment plants in districts Nadia, Hooghly and North 24-Parganas districts, West Bengal, India. As removal efficiencies of different treatment plants varied from 23 to 71%, which is largely governed by adsorption capacity of adsorbent and influencing environmental factors. Though investigated treatment plants removed substantial amount of As from tube well water, high As concentration in treated drinking water was retained after passing through the treatment plants. This high level of As concentration in tube well water and retention of high As concentration in treated drinking water were severe for the consumers which therefore, indicating the improvement of removal efficiency of treatment plant by meticulously considering favorable influencing factors or/and application of other high capacity treatment alternatives to adsorb the excess As retained in drinking water and regular monitoring of As concentration in the treated drinking water are indispensable

Case series: convalescent plasma therapy for patients with COVID-19 and primary antibody deficiency

Patients with primary antibody deficiency are at risk for severe and in many cases for prolonged COVID-19. Convalescent plasma treatment of immunocompromised individuals could be an option especially in countries with limited access to monoclonal antibody therapies. While studies in immunocompetent COVID19 patients have demonstrated only a limited benefit, evidence for the safety, timing, and effectiveness of this treatment in antibody-deficient patients is lacking. Here, we describe 16 cases with primary antibody deficiency treated with convalescent plasma in four medical centers. In our cohort, treatment was associated with a reduction in viral load and improvement of clinical symptoms, even when applied over a week after onset of infection. There were no relevant side effects besides a short-term fever reaction in one patient. Longitudinal full-genome sequencing revealed the emergence of mutations in the viral genome, potentially conferring an antibody escape in one patient with persistent viral RNA shedding upon plasma treatment. However, he resolved the infection after a second course of plasma treatment. Thus, our data suggest a therapeutic benefit of convalescent plasma treatment in patients with primary antibody deficiency even months after infection. While it appears to be safe, PCR follow-up for SARS-CoV-2 is advisable and early re-treatment might be considered in patients with persistent viral shedding

Understanding the errors of SHAPE-directed RNA structure modeling

Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms. Recent tests have shown that selective 2'-hydroxyl acylation by primer extension (SHAPE) can give near-zero error rates (0-2%) in modeling the helices of RNA secondary structure. Here, we benchmark the method using six molecules for which crystallographic data are available: tRNA(phe) and 5S rRNA from Escherichia coli, the P4-P6 domain of the Tetrahymena group I ribozyme, and ligand-bound domains from riboswitches for adenine, cyclic di-GMP, and glycine. SHAPE-directed modeling of these highly structured RNAs gave an overall false negative rate (FNR) of 17% and a false discovery rate (FDR) of 21%, with at least one helix prediction error in five of the six cases. Extensive variations of data processing, normalization, and modeling parameters did not significantly mitigate modeling errors. Only one varation, filtering out data collected with deoxyinosine triphosphate during primer extension, gave a modest improvement (FNR = 12%, and FDR = 14%). The residual structure modeling errors are explained by the insufficient information content of these RNAs' SHAPE data, as evaluated by a nonparametric bootstrapping analysis. Beyond these benchmark cases, bootstrapping suggests a low level of confidence (<50%) in the majority of helices in a previously proposed SHAPE-directed model for the HIV-1 RNA genome. Thus, SHAPE-directed RNA modeling is not always unambiguous, and helix-by-helix confidence estimates, as described herein, may be critical for interpreting results from this powerful methodology.Comment: Biochemistry, Article ASAP (Aug. 15, 2011

SEIS: Insight's Seismic Experiment for Internal Structure of Mars.

By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars' surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01&nbsp;Hz to 50&nbsp;Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1&nbsp;sps and a continuous compound VBB/SP vertical axis at 10&nbsp;sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking's Mars seismic monitoring by a factor of ∼ 2500 at 1&nbsp;Hz and ∼ 200 000 at 0.1&nbsp;Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars' surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of M w ∼ 3 at 40 ∘ epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution.Electronic supplementary materialThe online version of this article (10.1007/s11214-018-0574-6) contains supplementary material, which is available to authorized users

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

BACKGROUND: The severe acute respiratory syndrome (SARS) has recently been identified as a new clinical entity. SARS is thought to be caused by an unknown infectious agent. METHODS: Clinical specimens from patients with SARS were searched for unknown viruses with the use of cell cultures and molecular techniques. RESULTS: A novel coronavirus was identified in patients with SARS. The virus was isolated in cell culture, and a sequence 300 nucleotides in length was obtained by a polymerase-chain-reaction (PCR)-based random-amplification procedure. Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent of the nucleotide sequence). On the basis of the obtained sequence, conventional and real-time PCR assays for specific and sensitive detection of the novel virus were established. Virus was detected in a variety of clinical specimens from patients with SARS but not in controls. High concentrations of viral RNA of up to 100 million molecules per milliliter were found in sputum. Viral RNA was also detected at extremely low concentrations in plasma during the acute phase and in feces during the late convalescent phase. Infected patients showed seroconversion on the Vero cells in which the virus was isolated. CONCLUSIONS: The novel coronavirus might have a role