Early-childhood BMI trajectories: evidence from a prospective, nationally representative British cohort study

Background and Objectives: By age 5, 20% of British children are classed as overweight or obese, suggesting that early childhood is crucial for lifelong body mass index (BMI) trajectories. In this paper, we identify latent trajectories of early-childhood BMI from ages 3 to 11 years. Given the current context of growing socio-economic inequalities in childhood and adult overweight and obesity, we examine the socio-economic characteristics and mechanisms during pregnancy and infancy which underscore these trajectories.Subject and Methods: We use a nationally representative, prospective cohort study of 9699 children born in 2000–2002, living in the United Kingdom shortly after birth, with complete information on height and weight (measured by an interviewer) at ages 3, 5, 7 and 11. Trajectories of BMI are calculated using latent growth mixture models. Multinomial models characterize these trajectories by their socio-economic profiles and mechanisms during pregnancy and infancy.Results: Four trajectories were identified: two separate trajectories where BMI remains within a normal range (85% of the sample), an overweight trajectory (14.4%), and an obese trajectory (3.1%). No ‘declining BMI’ or late-onset groups were found. The obese group is already distinct from the other trajectories by age 3. The overweight group diverges from the normal groups around age 5. Strong socio-economic inequalities emerged; for the obese group, part of this disadvantage is mediated through early mechanisms such as pregnancy smoke and not initiating breastfeeding.Conclusions: This study provides strong evidence for the idea that childhood BMI trajectories develop early, especially for children who will follow an obese trajectory. Strong socio-economic patterns in these trajectories suggest that the observed trend in growing inequalities may be rooted in early life. Mediating mechanisms for the obese appear to be in the pregnancy and infant period, further research should explore mechanisms occurring around age 5 when the overweight trajectory diverges

Family structure and child health

This inter-disciplinary project investigates the relationship between family structure and early child health. The two main aims are: (1) to determine whether family structure and changes in family structure are associated with children's physical health in the Millennium Cohort Study; (2) to explore potential pathways through which these associations operate. In spite of much public debate around families, marriage, and child outcomes, UK literature on this topic remains incomplete. This thesis aims to fill two gaps: first, testing whether there is a link with children's physical health, rather than more commonly reported outcomes such as cognitive function or education achievements. Physical health outcomes included are respiratory health, childhood growth, and unintentional injuries. Second, few studies use prospective, longitudinal data and methods. Cross sectional studies cannot examine the direction of the relationship, nor capture the dynamics of changes in family structure. Here, longitudinal techniques test a complex model made up of variables ordered a priori. In unadjusted analyses, family structure presented a consistent gradient in child health: cross-sectionally, children living with married parents had better health than those living with cohabiting parents, while those living with lone parents had the worst health. Longitudinally, those who experienced changes in family structure fared worse than those living with continuously married parents, with some important exceptions, such as those living with cohabiting parents who subsequently married. Socio-economic factors were important predictors of family structure and child health. Proximal pathways through which socio-economic characteristics and family structure affected child health varied according to health outcome. Maternal mental health appeared to be important across outcomes. Concluding, this work shows the importance of using nuanced definitions of family, particularly when it comes to capturing its fluidity over time. Children who experienced changes in family structure were a heterogeneous group with diverse backgrounds and outcomes. Socio-economic factors emerged as important antecedents to both family structure and child health

Effective Action and Holography in 5D Gauge Theories

We apply the holographic method to 5D gauge theories on the warped interval. Our treatment includes the scalars associated with the fifth gauge field component, which appear as 4D Goldstone bosons in the holographic effective action. Applications are considered to two classes of models in which these scalars play an important role. In the Composite-Higgs (and/or Gauge-Higgs Unification) scenario, the scalars are interpreted as the Higgs field and we use the holographic recipe to compute its one-loop potential. In AdS/QCD models, the scalars are identified with the mesons and we compute holographically the Chiral Perturbation Theory Lagrangian up to p^4 order. We also discuss, using the holographic perspective, the effect of including a Chern-Simons term in the 5D gauge Lagrangian. We show that it makes a Wess-Zumino-Witten term to appear in the holographic effective action. This is immediately applied to AdS/QCD, where a Chern-Simons term is needed in order to mimic the Adler-Bardeen chiral anomaly.Comment: 37 pages; v2, minor changes, one reference added; v3, minor corrections, version published in JHE

Simple and Realistic Composite Higgs Models in Flat Extra Dimensions

We construct new composite Higgs/gauge-Higgs unification (GHU) models in flat space that overcome all the difficulties found in the past in attempting to construct models of this sort. The key ingredient is the introduction of large boundary kinetic terms for gauge (and fermion) fields. We focus our analysis on the electroweak symmetry breaking pattern and the electroweak precision tests and show how both are compatible with each other. Our models can be seen as effective TeV descriptions of analogue warped models. We point out that, as far as electroweak TeV scale physics is concerned, one can rely on simple and more flexible flat space models rather than considering their unavoidably more complicated warped space counterparts. The generic collider signatures of our models are essentially undistinguishable from those expected from composite Higgs/warped GHU models, namely a light Higgs, colored fermion resonances below the TeV scale and sizable deviations to the Higgs and top coupling.Comment: 30 figures, 9 figures; v2: minor improvements, one reference added, version to appear in JHE

Experimental performance comparison between circular and elliptical tubes in evaporative condensers

In refrigeration systems, evaporative condensers have two main advantages compared to other condensation heat exchangers: They operate at lower condensation temperature than traditional air-cooled condensers and require a lower quantity of water and pumping power compared to evaporative towers. The heat and mass transfer that occur on tube batteries are difficult to study. The aim of this work is to apply an experimental approach to investigate the performance of an evaporative condenser on a reduced scale by means of a test bench, consisting of a transparent duct with a rectangular test section in which electric heaters, inside elliptical pipes (major axis 32 mm, minor axis 23 mm), simulate the presence of the refrigerant during condensation. By keeping the water conditions fixed and constant, the operating conditions of the air and the inclination of the heat transfer geometry were varied, and this allowed to carry out a sensitivity analysis, depending on some of the main parameters that influence the thermo-fluid dynamic phenomena, as well as a performance comparison. The results showed that the heat transfer increases with the tube surface exposed directly to the air as a result of the increase in their inclination, that has been varied in the range 0–20°. For the investigated conditions, the average increase, resulting by the inclination, is 28%

Ethical issues in assistive ambient living technologies for ageing well

Assistive Ambient Living (AAL) in ageing refers to any device used to support ageing related psychological and physical changes aimed at improving seniors’ quality of life and reducing caregivers’ burdens. The diffusion of these devices opens the ethical issues related to their use in the human personal space. This is particularly relevant when AAL technologies are devoted to the ageing population that exhibits special bio-psycho-social aspects and needs. In spite of this, relatively little research has focused on ethical issues that emerge from AAL technologies. The present article addresses ethical issues emerging when AAL technologies are implemented for assisting the elderly population and is aimed at raising awareness of these aspects among healthcare providers. The overall conclusion encourages a person-oriented approach when designing healthcare facilities. This process must be fulfilled in compliance with the general principles of ethics and individual nature of the person devoted to. This perspective will develop new research paradigms, paving the way for fulfilling essential ethical principles in the development of future generations of personalized AAL devices to support ageing people living independently at their home

Enhancement of hydrogen production rate by high biomass concentrations of Thermotoga neapolitana

The objective of this study was to enhance the hydrogen production rate of dark fermentation in batch operation. For the first time, the hyperthermophilic pure culture of Thermotoga neapolitana cf. Capnolactica was applied at elevated biomass concentrations. The increase of the initial biomass concentration from 0.46 to 1.74 g cell dry weight/L led to a general acceleration of the fermentation process, reducing the fermentation time of 5 g glucose/L down to 3 h with a lag phase of 0.4 h. The volumetric hydrogen production rate increased from 323 (±11) to 654 (±30) mL/L/h with a concomitant enhancement of the biomass growth and glucose consumption rate. The hydrogen yield of 2.45 (±0.09) mol H2/mol glucose, the hydrogen concentration of 68% in the produced gas and the composition of the end products in the digestate, i.e. 62.3 (±2.5)% acetic acid, 23.5 (±2.9)% lactic acid and 2.3 (±0.1)% alanine, remained unaffected at increasing biomass concentrations