Effectiveness and Safety of Flexible Therapeutic Schemes Including First- and Secondgeneration Basal Insulins during a Pediatric Summer Diabetes Camp

Outcomes of insulin analogues in pediatric diabetes camps are poorly investigated; no data is available about insulin degludec (IDeg).Our aim was to assess impact of insulin therapy adopted by the participants to a 4-day diabetes camp held in 2017, hypothesizing a possible excess risk of hypoglycemia in patients treated with IDeg. Overall, 40 children with type 1 diabetes (mean age 13.4±3.0 years; 62.5% males) attended the camp (20.0% on continuous subcutaneous insulin infusion and 80.0% on multiple daily injections - MDI). Among children in MDI regimen, 71.9% were treated with IDeg as basal insulin and 28.1% with glargine U100 (IGlar). All patients used Lispro or Aspart as short-acting insulin. Daily plan of the camp included educational sessions, physical exercise, 3 main meals and 2 snacks. At the arrival, IGlar and short-acting insulin doses were revised according to existing guidelines, while IDeg dose was revised based on an empirical individualized approach. At the arrival, insulin doses were reduced in 22 participants (-19.4±10.5%), while doses were increased in 17 children (+17.8±12.7%), based on individual needs. No statistically significant between-group difference emerged in mean blood glucose and glucose variability. No excess risk of hypoglycemia was found in the IDeg group. The study suggests similar effectiveness and safety of different insulin schemes when associated with appropriate diabetes education and management, and flexible dose adjustments. Despite its longer halflife and the lack of a validated algorithm, IDeg was not associated with an excess risk of hypoglycemia

Search for dark photon decays to μ+μ−\mu^+\mu^- at NA62

International audienceThe NA62 experiment at CERN, designed to study the ultra-rare decay $K^+ \to \pi^+\nu\overline{\nu}$, has also collected data in beam-dump mode. In this configuration, dark photons may be produced by protons dumped on an absorber and reach a decay volume beginning 80 m downstream. A search for dark photons decaying in flight to $\mu^+\mu^-$ pairs is reported, based on a sample of $1.4 \times 10^{17}$ protons on dump collected in 2021. No evidence for a dark photon signal is observed. A region of the parameter space is excluded at 90% CL, improving on previous experimental limits for dark photon masses between 215 and 550 MeV$/c^2$

Search for leptonic decays of the dark photon at NA62

International audienceThe NA62 experiment at CERN, configured in beam-dump mode, has searched for dark photon decays in flight to electron-positron pairs using a sample of $1.4\times 10^{17}$ protons on dump collected in 2021. No evidence for a dark photon signal is observed. The combined result for dark photon searches in lepton-antilepton final states is presented and a region of the parameter space is excluded at 90% CL, improving on previous experimental limits for dark photon mass values between 50 and 600 MeV$/c^2$ and coupling values in the range $10^{-6}$ to $4\times10^{-5}$. An interpretation of the $e^+ e^-$ search result in terms of the emission and decay of an axion-like particle is also presented

Search for leptonic decays of the dark photon at NA62

International audienceThe NA62 experiment at CERN, configured in beam-dump mode, has searched for dark photon decays in flight to electron-positron pairs using a sample of $1.4\times 10^{17}$ protons on dump collected in 2021. No evidence for a dark photon signal is observed. The combined result for dark photon searches in lepton-antilepton final states is presented and a region of the parameter space is excluded at 90% CL, improving on previous experimental limits for dark photon mass values between 50 and 600 MeV$/c^2$ and coupling values in the range $10^{-6}$ to $4\times10^{-5}$. An interpretation of the $e^+ e^-$ search result in terms of the emission and decay of an axion-like particle is also presented

Development of a new CEDAR for kaon identification at the NA62 experiment at CERN

International audienceThe NA62 experiment at CERN utilises a differential Cherenkov counter with achromatic ring focus (CEDAR) for tagging kaons within an unseparated monochromatic beam of charged hadrons. The CEDAR-H detector was developed to minimise the amount of material in the path of the beam by using hydrogen gas as the radiator medium. The detector was shown to satisfy the kaon tagging requirements in a test-beam before installation and commissioning at the experiment. The CEDAR-H performance was measured using NA62 data collected in 2023

Development of a new CEDAR for kaon identification at the NA62 experiment at CERN

International audienceThe NA62 experiment at CERN utilises a differential Cherenkov counter with achromatic ring focus (CEDAR) for tagging kaons within an unseparated monochromatic beam of charged hadrons. The CEDAR-H detector was developed to minimise the amount of material in the path of the beam by using hydrogen gas as the radiator medium. The detector was shown to satisfy the kaon tagging requirements in a test-beam before installation and commissioning at the experiment. The CEDAR-H performance was measured using NA62 data collected in 2023

Measurement of the K+→π+γγK^+\to\pi^+\gamma\gamma decay

International audienceA sample of 3984 candidates of the $K^+\to\pi^+\gamma\gamma$ decay, with an estimated background of $291\pm14$ events, was collected by the NA62 experiment at CERN during 2017-2018. In order to describe the observed di-photon mass spectrum, the next-to-leading order contribution in chiral perturbation theory was found to be necessary. The decay branching ratio in the full kinematic range is measured to be $(9.61\pm0.17)\times10^{-7}$. The first search for production and prompt decay of an axion-like particle with gluon coupling in the process $K^+\to\pi^+a$, $a\to\gamma\gamma$ is also reported

A study of the K+→π0e+νγK^+ \to \pi^0 e^+ \nu \gamma decay

International audienceA sample of $1.3 \times 10^5$$K^+ \to \pi^0 e^+ \nu \gamma$ candidates with less than 1% background was collected by the NA62 experiment at the CERN SPS in 2017-2018. Branching fraction measurements are obtained at percent relative precision in three restricted kinematic regions, improving on existing results by a factor larger than two. An asymmetry, possibly related to T-violation, is investigated with no evidence observed within the achieved precision

Search for K+K^+ decays into the π+e+e−e+e−\pi^+e^+e^-e^+e^- final state

International audienceThe first search for ultra-rare $K^+$ decays into the $\pi^+e^+e^-e^+e^-$ final state is reported, using a dataset collected by the NA62 experiment at CERN in 2017-2018. An upper limit of $1.4\times 10^{-8}$ at 90% CL is obtained for the branching ratio of the $K^+\to\pi^+e^+e^-e^+e^-$ decay, predicted in the Standard Model to be $(7.2\pm0.7)\times 10^{-11}$. Upper limits at 90% CL are obtained at the level of $10^{-9}$ for the branching ratios of two prompt decay chains involving pair-production of hidden-sector mediators: $K^+\to\pi^+aa$, $a\to e^+e^-$ and $K^+\to\pi^+S$, $S\to A^\prime A^\prime$, $A^\prime\to e^+e^-$. The QCD axion is excluded as a possible explanation of the "17 MeV anomaly"

Measurement of the K+→π+γγK^+\to\pi^+\gamma\gamma decay

International audienceA sample of 3984 candidates of the $K^+\to\pi^+\gamma\gamma$ decay, with an estimated background of $291\pm14$ events, was collected by the NA62 experiment at CERN during 2017-2018. In order to describe the observed di-photon mass spectrum, the next-to-leading order contribution in chiral perturbation theory was found to be necessary. The decay branching ratio in the full kinematic range is measured to be $(9.61\pm0.17)\times10^{-7}$. The first search for production and prompt decay of an axion-like particle with gluon coupling in the process $K^+\to\pi^+a$, $a\to\gamma\gamma$ is also reported