PSY30 Cost-Consequence Analysis of a Treatment Strategy Including Ponatinib Compared to a Treatment Strategy Including Only the 2nd Generation Tyrosine Kinase Inhibitors (2g TKIs), Dasatinib or Nilotinib, in Resistant Patients with Philadelphia Chromosome-Positive (Ph+) Leukemia, in Italy

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Three years field trials to assess the effect of kaolin made particles and copper on olive-fruit fly (B.oleae Gmelin) infestations in Sicily

In most countries of Mediterranean Basin, Bactrocera oleae (Gmel), the olive fruit fly, is the key pest insect on olives. In Sicily this pest causes losses of fruits and a poor quality olive oil. Many researchers have recently carried out some field studies which were based on the use of kaolin and copper against the olive-fruit fly. In the last years these products have been effective several times in reducing olive fly infestation. Kaolin had, also, some important effect in reducing heat-stress in fruit crops and olive-trees. The aim of the present study was to assess the effect of kaolin and copper treatment on olive infestations in Sicily and to evaluate chemical and sensory parameters of oils extracted. For this reason, within 2003-2005, the IX Servizio of Assessorato Regionale Agricoltura e Foreste, selected some olive groves where to carry out trials with kaolin and copper and to realize information and divulgation activities

Early Detection of Wild Rocket Tracheofusariosis Using Hyperspectral Image-Based Machine Learning

Fusarium oxysporum f. sp. raphani is responsible for wilting wild rocket (Diplotaxis tenuifolia L. [D.C.]). A machine learning model based on hyperspectral data was constructed to monitor disease progression. Thus, pathogenesis after artificial inoculation was monitored over a 15-day period by symptom assessment, qPCR pathogen quantification, and hyperspectral imaging. The host colonization by a pathogen evolved accordingly with symptoms as confirmed by qPCR. Spectral data showed differences as early as 5-day post infection and 12 hypespectral vegetation indices were selected to follow disease development. The hyperspectral dataset was used to feed the XGBoost machine learning algorithm with the aim of developing a model that discriminates between healthy and infected plants during the time. The multiple cross-prediction strategy of the pixel-level models was able to detect hyperspectral disease profiles with an average accuracy of 0.8. For healthy pixel detection, the mean Precision value was 0.78, the Recall was 0.88, and the F1 Score was 0.82. For infected pixel detection, the average evaluation metrics were Precision: 0.73, Recall: 0.57, and F1 Score: 0.63. Machine learning paves the way for automatic early detection of infected plants, even a few days after infection

Non-ergodic site response model based on local recordings for Menta Dam site

The paper describes the development of a non-ergodic site response model for a strategic site in the Aspromonte mountains, in Southern Italy. Fractured metamorphic rocks belonging to Calabrian complex outcrop in this area, located in a region where Southern Apennines crustal faults and subduction of the Calabrian Arc contribute to the seismic hazard. At the site, three accelerometers are installed since 2016 as part of the monitoring system of the Menta Dam, a bituminous-faced rockfill dam constructed for the water supply of the region. Ground motions recorded at the site and elsewhere from regional crustal and subduction earthquakes have been used to evaluate region-specific source and path adjustment to global ground motion models (GMMs). Those regionally adjusted GMMs have, in turn, been used to evaluate the mean bias of site-specific recordings, which is used to estimate non-ergodic site response for the dam site. This analysis highlights that site-specific site response is appreciably larger than the global average prediction of GMMs for periods lower than 0.4s. A non-ergodic GMM is developed that accounts for these effects to be used in subsequent Probabilistic Site Hazard Analysis (PSHA)

Desenvolvimento de metodologia analítica para determinação de resíduos de medicamentos veterinários em carne bovina.

Objetivo de desenvolver e avalidar uma metodologia analítica, empregando a despersão da matriz em fase sólida (DMFS), seguida pela cromatografia gasosa acoplada á espectrometria de massa (GG-MS), na análise de resíduos de medicamentos veterinários ( carrapticidas), clorfensvinfos, fipronil cipermetrina, os quais são aplicados no rebanho bovino, utilizando como matriz de estudo a carne bovina

Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures.

Objective To investigate the effects of recombinant (r-) LH supplementation in “low responder” patients undergoing ovarian stimulation with r-FSH for an IVF program. The apoptosis rate in cumulus cells was used as an indicator of oocyte quality. Design Comparison of the rate of DNA fragmentation and caspase-3 activity in cumulus cells in women stimulated with r-LH and r-FSH, versus patients treated with r-FSH alone (control). Setting In vitro fertilization (IVF) laboratory. Patient(s) Forty patients undergoing assisted fertilization programs treated with a GnRH agonist, or r-FSH treatment begun on day 3 of the cycle (control). In the r-LH group, from day 8 of gonadotropin stimulation, 150 IU per day of r-LH were administered. Intervention(s) Terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine-triphosphate (dUTP) nick-end labeling (TUNEL) assay, and anti-caspase-3 cleaved immunoassay, to detect apoptosis in human cumulus cells. Main Outcome Measure(s) Difference in DNA fragmentation rate between cumulus cells derived from r-LH treatment and cumulus cells derived from control patients. Result(s) No differences were observed between the two groups in the total amount of r-FSH administered and in the number of retrieved oocytes per patient. A statistically significant increase in the number of immature oocytes and in the E2 serum peak was observed in the control group. The number of transferred embryos was significantly higher in the r-LH group. Pregnancy and implantation rates were higher in the r-LH group, but without statistical significance. The apoptosis rate in cumulus cells was higher in the control group than in the r-LH group. Conclusion(s) This study suggests that supplementation with r-LH improves the chromatin quality of cumulus cells involved in the control of oocyte maturation