150 research outputs found
Hypnosis for hot flashes among postmenopausal women study: A study protocol of an ongoing randomized clinical trial
- Author
- A Glaus
- Aimee K Johnson
- C Loprinzi
- C Loprinzi
- C Loprinzi
- C Loprinzi
- CL Loprinzi
- D Barton
- D Lykken
- E Lang
- F Kronenberg
- F Kronenberg
- Food and Drug Administration
- G Elkins
- G Elkins
- G Kimmick
- GA Bachmann
- Gary R Elkins
- GR Elkins
- GR Elkins
- HD Nelson
- J Pruessner
- J Webster
- JS Carpenter
- K Pandya
- KD Stein
- M Hunter
- M Jensen
- M Lamb
- National Institute of Health
- North American Menopause Society
- R Chelbowski
- R Goldberg
- R Uebelhack
- S Dormire
- S Quella
- V Stearns
- V Stearns
- V Sterns
- William I Fisher
- Working Group for the Women's Health Initiative Investigators
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Hot flashes are a highly prevalent problem associated with menopause and breast cancer treatments. The recent findings from the Women's Health Initiative have important implications for the significance of a non-hormonal, mind-body intervention for hot flashes in breast cancer survivors. Women who take hormone therapy long-term may have a 1.2 to 2.0 fold increased risk of developing breast cancer. In addition, it is now known that hormone therapy with estrogen and progestin is associated with increased risk of cardiovascular disease and stroke. Currently there are limited options to hormone replacement therapy as non-hormonal pharmacological agents are associated with only modest activity and many adverse side effects. Because of this there is a need for more alternative, non-hormonal therapies. Hypnosis is a mind-body intervention that has been shown to reduce self-reported hot flashes by up to 68% among breast cancer survivors, however, the use of hypnosis for hot flashes among post-menopausal women has not been adequately explored and the efficacy of hypnosis in reducing physiologically measured hot flashes has not yet been determined.</p> <p>Methods/design</p> <p>A sample of 180 post-menopausal women will be randomly assigned to either a 5-session Hypnosis Intervention or 5-session structured-attention control with 12 week follow-up. The present study will compare hypnosis to a structured-attention control in reducing hot flashes (perceived and physiologically monitored) in post-menopausal women in a randomized clinical trial. Outcomes will be hot flashes (self-report daily diaries; physiological monitoring; Hot Flash Related Daily Interference Scale), anxiety (State-Trait Anxiety Inventory; Hospital Anxiety and Depression Scale (HADS); anxiety visual analog scale (VAS rating); depression (Center for Epidemiologic Studies Depression Scale), sexual functioning (Sexual Activity Questionnaire), sleep quality (Pittsburgh Sleep Quality Index) and cortisol.</p> <p>Discussion</p> <p>This study will be the first full scale test of hypnosis for hot flashes; one of the first studies to examine both perceived impact and physiologically measured impact of a mind-body intervention for hot flashes using state-of-the-art 24 hour ambulatory physiological monitoring; the first study to examine the effect of hypnosis for hot flashes on cortisol; and the first investigation of the role of cognitive expectancies in treatment of hot flashes in comparison to a Structured-Attention Control.</p> <p>Trial Registration</p> <p>This clinical trial has been registered with ClinicalTrials.gov, a service of the U.S. National Institutes of Health, ClinicalTrials.gov Identifier: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01293695">NCT01293695</a>.</p
Default-Mode-Like Network Activation in Awake Rodents
- Author
- A Shekhar
- AG Garrity
- AJ Shackman
- AM Kelly
- AN Talalaenko
- BB Biswal
- CD Balaban
- CF Ferris
- Chih-Liang Chin
- DM Smith
- DN Pandya
- EE Abrahamson
- Feng Luo
- GE McClearn
- Gerard B. Fox
- Gerard J. Marek
- HD Critchley
- HS Mayberg
- J Fransson
- Jaymin Upadhyay
- JK Rilling
- JL Vincent
- JP Aggleton
- JS Damoiseaux
- K Masamoto
- K Ono
- KS Sink
- LJ Porrino
- Loan Miller
- M Davis
- M Davis
- M Tsanov
- Mark Day
- MD Greicius
- MD Greicius
- MD Greicius
- ME Raichle
- ME Raichle
- ML Kram
- ML Kram
- MN Baliki
- MW Woolrich
- N Zhang
- P Boveroux
- Paxinos G
- Pedro Antonio Valdes-Sosa
- Prasant Chandran
- S Whitfield-Gabrieli
- Scott J. Baker
- SM Smith
- TJ Balkin
- TP Vahl
- Unal Sakoglu
- WC Drevets
- WW Seeley
- Younglim Lee
- Z Liang
- Publication venue
- Public Library of Science
- Publication date
- 18/11/2011
- Field of study
During wakefulness and in absence of performing tasks or sensory processing, the default-mode network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. Non-human primate and human CNS imaging studies have identified the DMN in these two species. Clinical imaging studies have shown that the pattern of activity within the DMN is often modulated in various disease states (e.g., Alzheimer's, schizophrenia or chronic pain). However, whether the DMN exists in awake rodents has not been characterized. The current data provides evidence that awake rodents also possess ‘DMN-like’ functional connectivity, but only subsequent to habituation to what is initially a novel magnetic resonance imaging (MRI) environment as well as physical restraint. Specifically, the habituation process spanned across four separate scanning sessions (Day 2, 4, 6 and 8). At Day 8, significant (p<0.05) functional connectivity was observed amongst structures such as the anterior cingulate (seed region), retrosplenial, parietal, and hippocampal cortices. Prior to habituation (Day 2), functional connectivity was only detected (p<0.05) amongst CNS structures known to mediate anxiety (i.e., anterior cingulate (seed region), posterior hypothalamic area, amygdala and parabracial nucleus). In relating functional connectivity between cingulate-default-mode and cingulate-anxiety structures across Days 2-8, a significant inverse relationship (r = −0.65, p = 0.0004) was observed between these two functional interactions such that increased cingulate-DMN connectivity corresponded to decreased cingulate anxiety network connectivity. This investigation demonstrates that the cingulate is an important component of both the rodent DMN-like and anxiety networks
Performance of the ATLAS forward proton Time-of-Flight detector in Run 2
- Author
- Adam Bourdarios C
- Agaras MN
- Alexopoulos T
- Andeen T
- Angelidakis S
- Arnaez O
- Bakshi Gupta D
- Berger N
- Bernardi G
- Bomben M
- Brahimi N
- Burghgrave B
- Burton CD
- Cakir O
- Canbay AC
- Cardenas JCJ
- Castillo FL
- Cavaliere T
- Chekanov S
- Cheu E
- Choi K
- Costanza F
- Cui Z
- Darmora S
- De K
- Delmastro M
- Di Ciaccio L
- Drivas-Koulouris I
- Duran Yildiz H
- Farbin A
- Fassouliotis D
- Filmer EK
- Fountas L
- Gazis EN
- Ghosh A
- Gingrich DM
- Gkialas I
- Grant CM
- Hadavand HK
- Hopkins WH
- Hoya J
- Hryn'ova T
- Huseynov N
- Jackson P
- Johns KA
- Kitsaki C
- Koletsou I
- Kong AXY
- Kourkoumelis C
- Kuday S
- Lampl W
- Levêque J
- Lewis DJ
- Li A
- Li T
- Lindley RE
- Lindon JH
- Little JD
- Loch P
- Lorenzo Martinez N
- Luongo NA
- Maltezos S
- Marchiori G
- Metcalfe J
- Mete AS
- Myers AJ
- Nakkalil K
- Nishu N
- Onyisi PUE
- Ozturk N
- Panchal DK
- Pandya HD
- Paramonov A
- Perganti M
- Pinfold JL
- Potti H
- Proudfoot J
- Ruggeri TA
- Rutherfoord JP
- Sardain J
- Sauvan E
- Shen Q
- Sultansoy S
- Ting EXL
- Tost M
- Turk Cakir I
- Tzanis P
- Unal M
- Usai G
- Van Gemmeren P
- Varnes EW
- Wamorkar T
- Wang C
- Wang R
- White A
- White MJ
- Zhang J
- Zhang Y
- Zhou H
- Zhou Y
- Publication venue
- IOP Publishing
- Publication date
- 21/05/2024
- Field of study
We present performance studies of the Time-of-Flight (ToF) subdetector of the ATLAS Forward Proton (AFP) detector at the LHC. Efficiencies and resolutions are measured using high-statistics data samples collected at low and moderate pile-up in 2017, the first year when the detectors were installed on both sides of the interaction region. While low efficiencies are observed, of the order of a few percent, the resolutions of the two ToF detectors measured individually are 21 ps and 28 ps, yielding an expected resolution of the longitudinal position of the interaction, z vtx, in the central ATLAS detector of 5.3 ± 0.6 mm. This is in agreement with the observed width of the distribution of the difference between z vtx, measured independently by the central ATLAS tracker and by the ToF detector, of 6.0 ± 2.0 mm
Autismo: neuroimagem
- Author
- Abell F
- Allison T
- Ashburner J
- Aylward EH
- Baron-Cohen S
- Baron-Cohen S
- Belin P
- Blakemore SJ
- Boddaert N
- Boddaert N
- Boddaert N
- Boddaert N
- Bolton PF
- Castelli F
- Chiron C
- Chugani HT
- Cody H
- Courchesne E
- Courchesne E
- Critchley HD
- De Volder A
- Egaas B
- Fombonne E
- Fombonne E
- Fombonne E
- Friston KJ
- Frith Uta
- Garreau B
- Gervais H
- Gillberg C
- Gillberg C
- Gillberg C
- Gloor P
- Hadjikhani N
- Hall GB
- Happe F
- Haxby JV
- Haznedar MM
- Herold S
- Horwitz B.
- Howard MA
- Hubl D
- Isabelle Meresse
- Kanner L
- Kanwisher N
- Klin A
- Levitt JG
- Manes F
- Mountz JM
- Muller RA
- Mônica Zilbovicius
- Nathalie Boddaert
- Ohnishi T
- Pandya DN
- Pelphrey KA
- Pierce K
- Pierce K
- Piven J
- Piven J
- Piven J
- Piven J
- Piven J
- Rapin I
- Rapin I
- Ring HA
- Rizzolatti G
- Rumsey JM
- Saitoh O
- Schultz RT
- Sparks BF
- Zilbovicius M
- Zilbovicius M
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Emergence of Emotions
- Author
- A Baird
- A Bechara
- A Berti
- A Demertzi
- A Etkin
- A Gasbarri
- A Kling
- A Siegel
- AC Scott
- AC Scott
- AC Scott
- AE Hillis
- AE Hillis
- AG Hudetz
- AK Afifi
- AM Theirry
- AR Damasio
- AR Damasio
- AR Luria
- AW Zybrozyna
- AY Deutch
- B Baars
- B Best
- B Best
- B Bogarts
- B Coe
- B Hyland
- B Kissin
- B Kolb
- B Kolb
- B Seltzer
- BE Morton
- BH Turner
- BK Anand
- BM Evans
- BN Bunnell
- BR Kaada
- BR Kaada
- BS Kapp
- BW Robinson
- C Baleydier
- C Cavada
- C Koch
- C Meyer
- CA Hutcherson
- CA Unsworth
- CB Holroyd
- CD Yingling
- CJ Bruce
- CJ Bruce
- CM Butter
- CN Boehler
- CS Carter
- D Blumer
- D Ongur
- D Ongur
- D Pare
- DB Hier
- DF Benson
- DF Benson
- DF Swaab
- DF Swaab
- DG Licter
- DH Weissman
- DM Tucker
- DN Pandya
- DN Pandya
- DT Stuss
- DT Stuss
- DV Newman
- DZ Philip
- E Garcia-Rill
- E Garcia-Rill
- EA Murray
- EA Osuch
- EA Phelps
- EG Jones
- EK Sauerland
- EK Vogel
- ET Rolls
- EW Powell
- EW Powell
- F Crick
- F Crick
- F Laplante
- F Sanides
- FE Polli
- G Bush
- G Bush
- G Bush
- G Goldberg
- G O’Brien
- G Rees
- G Rees
- G Rull
- G Schoenbaum
- G Tononi
- G Tononi
- G Vallar
- GE Alexander
- GE Alexander
- GM Young
- GW Hoesen Van
- GW Hoesen Van
- H Burton
- H Garavan
- H Hecaen
- H Kluver
- H Terzian
- H Ursin
- HBM Uylings
- HD Critchley
- HD Critchley
- HJ Groenewegen
- HP Blumberg
- HP Rang
- HS Mayberg
- HS Mayberg
- HT Blair
- I Ganguli
- I Schutze
- IB Mauss
- J Buttner-Ennever
- J Daltrozzo
- J Daltrozzo
- J Decety
- J Hyvarinen
- J McCrone
- J Olds
- J Rothwell
- J Sauguet
- J Siegel
- J Tanji
- JA Gray
- JB Hale
- JB Mattingley
- JC LeDoux
- JE Desmedt
- JE Skinner
- JJ Fahrenfort
- JJ Paton
- JJ Prinz
- JJ Todd
- JM Allman
- JM Allman
- JM Fuster
- JM Fuster
- JM Fuster
- JM Fuster
- JM Fuster
- JM Fuster
- JM Goldstein
- JM Orgogozo
- JR Marshall
- JS Bakin
- JV Pardo
- JW Brown
- K Amunts
- KC Bickart
- KG Volz
- KJ Ressler
- KL Phan
- KM Heilman
- KM Heilman
- KM Heilman
- KM Perryman
- KN Ochsner
- KT Stuss
- L Helmuth
- L Lanteaume
- L Pezawas
- LA Vignolo
- LF Barrett
- LM Gunne
- LM Williams
- M Beauregard
- M Bertolucci-Angio
- M Botvinik
- M Davis
- M Husain
- M Husain
- M Kim
- M Oscar-Berman
- M Petrides
- M Petrides
- M Rowlands
- M Steriade
- M Steriade
- M Steriade
- M Steriade
- M Szalavitz
- M Thiebaut de Schotten
- M Velmans
- M Waraczynski
- M Wiesendanger
- MD Egger
- MD Robinson
- ME Olds
- ME Raichle
- MF Rushworth
- MI Posner
- MJ Frank
- ML Kringelbach
- ML Kringlebach
- ML Phillips
- ML Phillips
- MS Avidan
- MS George
- N Lapitskaya
- N Tsuchiya
- NH Donegan
- NW Weinberger
- O Gillath
- OA Imas
- P Bartolomeo
- P Gloor
- P Luu
- P Nachev
- P Nathan
- PB Reiner
- PD Maclean
- PE Roland
- PE Roland
- PJ John
- PL Jackson
- PS Goldman-Rakic
- R Elliott
- R Joseph
- R Joseph
- R Joseph
- R Joseph
- R Joseph
- R Joseph
- R Kalisch
- R McClamrock
- RA Hannaman
- RA Sieb
- RA Sieb
- RA Sieb
- RA Sieb
- RA Sieb
- RA Sieb
- RA Sieb
- RA Sieb
- RD Lane
- RE Myers
- RJ Compton
- RJ Davidson
- RJ Dolan
- RJR Blair
- RL Strub
- RM Sapolsky
- RP Vertes
- S Brown
- S Budhani
- S Burlet
- S Kinomura
- S Maren
- S Nieuwenhuis
- SE Mann
- SF Maier
- SF Taylor
- SJ Dimond
- SJ Dimond
- SJ Luck
- SL Rauch
- SL Rauch
- SM Zeki
- SO Bruno
- SP Appleton
- T Alter
- T Asari
- T Liversedge
- T Pfister
- T Ro
- TL Brink
- TM Preuss
- TN Johnson
- U Lee
- VA Lamme
- VB Brooks
- VS Caviness
- W Schultz
- WA Lishman
- WC Drevets
- WC Drevets
- WC Drevets
- WF Ganong
- WJ Gehring
- YI Sheline
- Z Mehta
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Emotion is conscious experience. It is the affective aspect of consciousness. Emotion arises from sensory stimulation and is typically accompanied by physiological and behavioral changes in the body. Hence an emotion is a complex reaction pattern consisting of three components: a physiological component, a behavioral component, and an experiential (conscious) component. The reactions making up an emotion determine what the emotion will be recognized as. Three processes are involved in generating an emotion: (1) identification of the emotional significance of a sensory stimulus, (2) production of an affective state (emotion), and (3) regulation of the affective state. Two opposing systems in the brain (the reward and punishment systems) establish an affective value or valence (stimulus-reinforcement association) for sensory stimulation. This is process (1), the first step in the generation of an emotion. Development of stimulus-reinforcement associations (affective valence) serves as the basis for emotion expression (process 2), conditioned emotion learning acquisition and expression, memory consolidation, reinforcement-expectations, decision-making, coping responses, and social behavior. The amygdala is critical for the representation of stimulus-reinforcement associations (both reward and punishment-based) for these functions. Three distinct and separate architectural and functional areas of the prefrontal cortex (dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex) are involved in the regulation of emotion (process 3). The regulation of emotion by the prefrontal cortex consists of a positive feedback interaction between the prefrontal cortex and the inferior parietal cortex resulting in the nonlinear emergence of emotion. This positive feedback and nonlinear emergence represents a type of working memory (focal attention) by which perception is reorganized and rerepresented, becoming explicit, functional, and conscious. The explicit emotion states arising may be involved in the production of voluntary new or novel intentional (adaptive) behavior, especially social behavior
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amor Dos Santos SP
- Amos KR
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Aranzabal N
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assamagan K
- Astalos R
- Atashi S
- Atkin RJ
- Atkinson M
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Bagnaia P
- Bahmani M
- Bailey AJ
- Bailey VR
- Baines JT
- Baines L
- Bakalis C
- Baker OK
- Bakos E
- Bakshi Gupta D
- Balakrishnan V
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Baltes LM
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Bansal S
- Barak L
- Barakat M
- Barberio EL
- Barberis D
- Barbero M
- Barel MZ
- Barends KN
- Barillari T
- Barisits M-S
- Barklow T
- Baron Moreno DA
- Baron P
- Baroncelli A
- Barone G
- Barr AJ
- Barr JD
- Barranco Navarro L
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barros Teixeira MG
- Barsov S
- Bartels F
- Bartoldus R
- Barton AE
- Bartos P
- Basan A
- Baselga M
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Battulga D
- Bauce M
- Bauer M
- Bauer P
- Bazzano Hurrell LT
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belyaev NL
- Benchekroun D
- Bendebba F
- Benhammou Y
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Beringer J
- Bernardi G
- Bernius C
- Bernlochner FU
- Bernon F
- Berry T
- Berta P
- Berthold A
- Bertram IA
- Bethke S
- Betti A
- Bevan AJ
- Bhamjee M
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
- Bianchi RM
- Bianco G
- Biebel O
- Bielski R
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondini A
- Birch-sykes CJ
- Bird GA
- Birman M
- Biros M
- Biryukov S
- Bisanz T
- Bisceglie E
- Biswal JP
- Biswas D
- Bitadze A
- Bjørke K
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blumenthal J
- Bobbink GJ
- Bobrovnikov VS
- Boehler M
- Boehm B
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Bordulev IS
- Borecka-Bielska HM
- Borgna LS
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Bouchhar N
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bouquet R
- Boveia A
- Boyd J
- Boye D
- Boyko IR
- Bracinik J
- Brahimi N
- Brandt G
- Brandt O
- Braren F
- Brau B
- Brau JE
- Brener R
- Brenner L
- Brenner R
- Bressler S
- Britton D
- Britzger D
- Brock I
- Brooijmans G
- Brooks WK
- Brost E
- Brown LM
- Bruce LE
- Bruckler TL
- Bruckman de Renstrom PA
- Bruni A
- Bruni G
- Bruschi M
- Bruscino N
- Brüers B
- Buanes T
- Buat Q
- Buchin D
- Buckley AG
- Bulekov O
- Bullard BA
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burlayenko O
- Burr JTP
- Burton CD
- Burzynski JC
- Busch EL
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
- Cabrera Urbán S
- Cadamuro L
- Caforio D
- Cai H
- Cai Y
- Cairo VMM
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarero Munoz D
- Camarri P
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cantero J
- Cao Y
- Capocasa F
- Capua M
- Carbone A
- Cardarelli R
- Cardenas JCJ
- Cardillo F
- Carli T
- Carlino G
- Carlotto JI
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- Yacoob S
- Yamaguchi Y
- Yamashita E
- Yamauchi H
- Yamazaki T
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- Yan J
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- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
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- Agrewala JN
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- Aguilar PV
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- Ahmed ZM
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- Shravage BV
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- Shutt TE
- Sica V
- Siddiqui A
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- Silva BJDA
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- Silva-Pavez E
- Silvente-Poirot S
- Simmonds RE
- Simon AK
- Simon H-U
- Simons M
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- Skirycz A
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- Sluimer JC
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- Soukas AA
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- Srinivas Bharath MM
- St Clair D
- Stagni V
- Staiano L
- Stallings CL
- Stalnecker CA
- Stankov MV
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- Stefan K
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- Steffan JS
- Steinkasserer A
- Stenmark H
- Sterneckert J
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- Strohecker AM
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- Subauste CS
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- Sue CM
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- Titorenko VI
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- Tomaipitinca L
- Tomar D
- Tomas-Zapico C
- Tomić S
- Tong BC-K
- Tong C
- Tong C-K
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- Tooze SA
- Torgersen ML
- Torii S
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- Torriglia A
- Towers CG
- Towns R
- Toyokuni S
- Trajkovic V
- Tramontano D
- Tran Q-G
- Travassos LH
- Trelford CB
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- Trougakos IP
- Tsao BP
- Tschan MP
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- Tsugawa H
- Tsvetkov AS
- Tumbarello DA
- Tumtas Y
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- Tuxworth RI
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- Valko A
- Vallee RB
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- van der Veen S
- Van Kaer L
- van Loosdregt J
- van Wijk SJL
- Vandenberghe W
- Vanhorebeek I
- Vannier-Santos MA
- Vannini N
- Vanrell MC
- Vantaggiato C
- Varano G
- Varela-Nieto I
- Varga M
- Vasconcelos MH
- Vats S
- Vavvas DG
- Vega-Naredo I
- Vega-Rubin-de-Celis S
- Velasco G
- Vellai T
- Vellenga E
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- Velázquez AP
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- Waguri S
- Waite KA
- Wakatsuki S
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- Wang B
- Wang C
- Wang C
- Wang C
- Wang C-Y
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- Wang W
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- Wang X
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- Wang Y
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- Warnes G
- Warnsmann V
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- Weaver TE
- Wegrzyn G
- Wehman AM
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- Wei L
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- Wei Y
- Weiergräber OH
- Weihl CC
- Weindl G
- Weiskirchen R
- Wells A
- Wen RH
- Wen X
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- Weykopf B
- Wheatley SP
- Whitton JL
- Whitworth AJ
- Wiktorska K
- Wildenberg ME
- Wileman T
- Wilkinson S
- Willbold D
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- Williams RSB
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- Winsor NJ
- Witkin SS
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- Woehlbier U
- Wollert T
- Wong E
- Wong JH
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- Wong VKW
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- Wu A-G
- Wu C
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- Wu KK
- Wu M
- Wu S
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- Wu S-Y
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- Wu WKK
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- Xavier RJ
- Xia H
- Xia L
- Xia Z
- Xiang G
- Xiang J
- Xiang M
- Xiang W
- Xiao B
- Xiao G
- Xiao H
- Xiao H-T
- Xiao J
- Xiao L
- Xiao S
- Xiao Y
- Xie B
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- Xu C
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- Yakhine-Diop SMS
- Yamaguchi M
- Yamaguchi O
- Yamamoto A
- Yamashina S
- Yan S
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- Yang Q
- Yang S
- Yang S
- Yang S-F
- Yang W
- Yang WY
- Yang X
- Yang X
- Yang Y
- Yang Y
- Yao H
- Yao S
- Yao X
- Yao Y-G
- Yao Y-M
- Yasui T
- Yazdankhah M
- Yen PM
- Yi C
- Yi-Ren Hong C-WH
- Yin X-M
- Yin Y
- Yin Z
- Yin Z
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- Ying Z
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- Yiu SPT
- Yoo YH
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- Yoshii SR
- Yoshimori T
- Yousefi B
- Yu B
- Yu H
- Yu J
- Yu J
- Yu L
- Yu M-L
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- Yu WH
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- Yuan L-Q
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- Yuan S-SF
- Yuan Y
- Yuan Z
- Yue J
- Yue Z
- Yun J
- Yung RL
- Zacks DN
- Zaffagnini G
- Zambelli VO
- Zanella I
- Zang QS
- Zanivan S
- Zappavigna S
- Zaragoza P
- Zarbalis KS
- Zarebkohan A
- Zarrouk A
- Zeitlin SO
- Zeng J
- Zeng J-D
- Zhan L
- Zhang B
- Zhang DD
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H-L
- Zhang J
- Zhang J
- Zhang J-P
- Zhang KYB
- Zhang L
- Zhang L
- Zhang L
- Zhang L
- Zhang LW
- Zhang M
- Zhang P
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
- Zhang XD
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-D
- Zhang Y-Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
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- Zhao H
- Zhao L
- Zhao S
- Zhao T
- Zhao X-F
- Zhao Y
- Zhao Y
- Zhao Y
- Zhao Y
- Zheng G
- Zheng K
- Zheng L
- Zheng S
- Zheng X-L
- Zheng Y
- Zheng Z-G
- Zhivotovsky B
- Zhong Q
- Zhou A
- Zhou B
- Zhou C
- Zhou G
- Zhou H
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou J
- Zhou K
- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Design of a randomized controlled trial of Internet-based cognitive behavioral therapy for treatment-induced menopausal symptoms in breast cancer survivors
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- (CVZ) Cvz
- A Barak
- A Barak
- A Bardia
- A Benshushan
- A Briggs
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- A MacLennan
- A Weerd de
- AH Boekhout
- AS Zigmond
- AY Rostom
- B Ayers
- B Palmqvist
- C Crandall
- C Owusu
- CA McHorney
- CD Sherbourne
- CH Mom
- CL Shapiro
- D Stan
- DJ Anderson
- E Fenwick
- E Mann
- G Alkhaldi
- G Andersson
- G Andersson
- G Clarke
- GR Norman
- H Christensen
- HD Nelson
- Hester S. A. Oldenburg
- I Ajzen
- I Bjelland
- International Committee of Medical Journal Editors
- J Bines
- J Brazier
- J Carpenter
- J Cohen
- J Howard-Anderson
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- JE Owen
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- K Thirlaway
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- KM Melville
- L Donkin
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- L Lindh-Astrand
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- LP Garrison Jr
- M Hunter
- Marc van Beurden
- Marieke van Leeuwen
- MC Weinstein
- MJ Rendall
- MP Coleman
- MS Hunter
- MS Hunter
- MS Hunter
- MS Hunter
- MS Hunter
- MS Hunter
- MS Hunter
- Myra S. Hunter
- N Angelopoulos
- N Biglia
- NE Avis
- Neil K. Aaronson
- NK Aaronson
- NW Scott
- P Cuijpers
- P Diggle
- PA Ganz
- PA Ganz
- R Sadovsky
- R Schwarzer
- RJ Couzi
- RR Freedman
- S Norton
- S YoungMcCaughan
- SE Fugate
- SFA Duijts
- SM Rosenberg
- T Berger
- T Berger
- TD Shanafelt
- TI Barron
- TL Lash
- V Spek
- Valesca Retèl
- Vera Atema
- Y Leykin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recommended from our members
Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021
- Author
- Aali A
- Abate KH
- Abd-Elsalam S
- Abdurehman AM
- Abebe G
- Abidi H
- Aboagye RG
- Abolhassani H
- Aboye GB
- Abtew YD
- Accrombessi MMK
- Adane DE
- Adane TD
- Addo IY
- Adesina MA
- Adeyinka DA
- Adnani QES
- Afzal MS
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- Agustina R
- Ahinkorah BO
- Ahmad A
- Ahmad S
- Ahmadi S
- Ahmed A
- Aiman W
- Ajami M
- Akbarialiabad H
- Al-Aly Z
- Al-Raddadi RM
- Al-Rifai RH
- Alahdab F
- Alam N
- Alemayehu A
- Alhassan RK
- Ali MA
- Almustanyir S
- Altirkawi KA
- Alvand S
- Alvis-Guzman N
- Amer YSAD
- Ameyaw EK
- Amu H
- Anagaw TF
- Ancuceanu R
- Anoushirvani AA
- Antwi MH
- Anvari D
- Arabloo J
- Aravkin AY
- Ariffin H
- Aripov T
- Arja A
- Arndt MB
- Arulappan J
- Aruleba RT
- Ashraf T
- Asresie MB
- Athari SS
- Atlaw D
- Aujayeb A
- Awoke AA
- Awoke MA
- Azadnajafabad S
- Azangou-Khyavy M
- Badawi A
- Badiye AD
- Baghcheghi N
- Bagheri N
- Bagherieh S
- Baig AA
- Bali AO
- Banach M
- Banik PC
- Bantie AT
- Barr RD
- Barrow A
- Bashiri A
- Basu S
- Batiha A-MM
- Begum T
- Belete MA
- Belo L
- Bensenor IM
- Berhie AY
- Bhagavathula AS
- Bhardwaj N
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- Bhat AN
- Bhutta ZA
- Bikbov B
- Billah SM
- Birara S
- Bishai JD
- Bitaraf S
- Boloor A
- Botelho JS
- Burkart K
- Calina D
- Cembranel F
- Cercy KM
- Chakraborty PA
- Chanie GS
- Chattu VK
- Chen CS
- Chien J-H
- Chukwu IS
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- Criqui MH
- Cruz-Martins N
- Dadras O
- Dagnew GW
- Dai X
- Danawi HA
- Dandona L
- Dandona R
- Darshan BB
- Darwesh AM
- Das Gupta R
- Das JK
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- De la Cruz-Gongora V
- Defo BK
- Demisse FW
- Demissie S
- Demsie DG
- Desai HD
- Desalegn M
- Dessalegn FN
- Dessie G
- Dharmaratne SD
- Dhimal M
- Dhingra S
- Diaz D
- Didehdar M
- Dirac MA
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- Doku PN
- Dongarwar D
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- Edinur HA
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- El-Huneidi W
- Elagali AEM
- Elbahnasawy MA
- Elbarazi I
- ElGohary GMT
- Elhadi M
- Elmonem MA
- Enyew DB
- Eshetu HB
- Ewald SB
- Ezzeddini R
- Fagbamigbe AF
- Fasanmi AO
- Fatehizadeh A
- Fekadu G
- Feyisa BR
- Fischer F
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- Gadanya MA
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- Ghafourifard M
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- Ghashghaee A
- Gholamalizadeh M
- Ghozy S
- Gizaw ATT
- Glasbey JC
- Golechha M
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- Golitaleb M
- Goulart AC
- Goyomsa GG
- Guadie HA
- Gubari MIM
- Gudisa Z
- Gunawardane DA
- Gupta R
- Gupta S
- Gupta VK
- Guta A
- Habibzadeh P
- Hagins H
- Hamidi S
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- Hanif A
- Hannan MA
- Harapan H
- Harorani M
- Hasaballah AI
- Hasan MM
- Hasani H
- Hassankhani H
- Hassen MB
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- Heyi DZ
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- Hussain S
- Hussien FM
- Ibitoye SE
- Ilesanmi OS
- Ilic IM
- Immurana M
- Inbaraj LR
- Islam SMS
- Ismail NE
- Jamshidi E
- Janodia MD
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- Jayaram S
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- Jonas JB
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- Kalankesh LR
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- Kanko TK
- Karaye IM
- Kashoo FZ
- Kassebaum NJ
- Katoto PDMC
- Kauppila JH
- Kaur H
- Kayode GA
- Kebede AD
- Keshri VR
- Keykhaei M
- Khader YS
- Khajuria H
- Khalid N
- Khammarnia M
- Khan IA
- Khan MAB
- Khatab K
- Khazaei Z
- Khubchandani J
- Kim YJ
- Kimokoti RW
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- Legesse SM
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- Linh GV
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- Mai TNT
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- McHugh TA
- Medina JRC
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- Mentis A-FA
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- Merin LJ
- Mestrovic T
- Miazgowski T
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- Misra S
- Mohammad DK
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- Murray CJL
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- Salem MR
- Samy AM
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- Santos IS
- Satpathy M
- Saya GK
- Seboka BT
- Senbeta AM
- Senthilkumaran S
- Seylani A
- Shafeghat M
- Shah PA
- Shaikh MA
- Shanawaz M
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- Sima AR
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- Siraj MS
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- Skryabina AA
- Solomon Y
- Song Y
- Soodejani MT
- Sorensen RJD
- Stanaway JD
- Suchdev PS
- Sufiyan MB
- Sultana S
- Swamy SN
- Syed ZQ
- Szeto MD
- Tabaeian SP
- Tahamtan A
- Tahbaz SV
- Taheri M
- Tamir Z
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- Thiyagarajan A
- Ticoalu JHV
- Tigabu BM
- Tiyuri A
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- Ullah I
- Umer AA
- Unnikrishnan B
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- Verma M
- Veroux M
- Vervoort D
- Vilchis-Tella VM
- Wagaye B
- Weldegebreal F
- Wickramasinghe ND
- Woldemariam M
- Wonde TE
- Wubetie GA
- Xu X
- Yari K
- Yazdanpanah F
- Yehualashet SS
- Yigit A
- Yigit V
- Yisihak E
- Yon DK
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- Young MF
- Yu C
- Yunusa I
- Zahir M
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- Zare I
- Zareshahrabadi Z
- Zenebe GA
- Zhang Z-J
- Zheng P
- Zoeckler LZ
- Zoladl M
- Publication venue
- Elsevier
- Publication date
- 29/08/2023
- Field of study
Background
Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories.
Methods
We estimated population-level distributions of haemoglobin concentration by age and sex for each location from 1990 to 2021. We then calculated anaemia burden by severity and associated years lived with disability (YLDs). With data on prevalence of the causes of anaemia and associated cause-specific shifts in haemoglobin concentrations, we modelled the proportion of anaemia attributed to 37 underlying causes for all locations, years, and demographics in the Global Burden of Disease Study 2021.
Findings
In 2021, the global prevalence of anaemia across all ages was 24·3% (95% uncertainty interval [UI] 23·9–24·7), corresponding to 1·92 billion (1·89–1·95) prevalent cases, compared with a prevalence of 28·2% (27·8–28·5) and 1·50 billion (1·48–1·52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52·0 million (35·1–75·1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic Index. The most common causes of anaemia YLDs in 2021 were dietary iron deficiency (cause-specific anaemia YLD rate per 100 000 population: 422·4 [95% UI 286·1–612·9]), haemoglobinopathies and haemolytic anaemias (89·0 [58·2–123·7]), and other neglected tropical diseases (36·3 [24·4–52·8]), collectively accounting for 84·7% (84·1–85·2) of anaemia YLDs.
Interpretation
Anaemia remains a substantial global health challenge, with persistent disparities according to age, sex, and geography. Estimates of cause-specific anaemia burden can be used to design locally relevant health interventions aimed at improving anaemia management and prevention.
Funding
Bill & Melinda Gates Foundation
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