Biopolymer: A Novel Bioexcipient

Polymers are the key material in design of drug delivery systems. These have been shown as the spine for drug development process. These accept an essential part in rising of novel drug delivery systems to crush different intricacies in drug delivery. These are used for controlling the appearance of the drug in needed manner. The hydrophilic and lipophilic polymers are the most ideal choice for getting the ideal conveyance in controlled, manner at the target sites. Isolated of this, these fabricated and semisynthetic polymers are made by different chemical reactions and purification measures. Since these are prepared by different unit operations which are costly. By and by days different investigates are being examined for avoiding the characteristic, physiological and reasonable issues related with the synthetic and semisynthetic polymers. So an alternative rather than synthetic and semisynthetic polymers are being investigated having interest, probability, and any leftover benefits with least troublesome ramifications for environment and physiology of the people. One of the alternatives as opposed to designed and semisynthetic polymers is biopolymers which have pulled in the thought of researchers by using an economical procedures. Biopolymers are novel, adroit and sharp polymers which have been confined from various basic sources. Biopolymers isolated from natural sources might be utilized as novel excipients having a polymeric nature. These isolated biopolymers have superb bioretardant, bio stabilizer, and mucoadhesive properties. These have the brilliant film-framing capacity and biocompatibility properties. The isolated bio-polymers have great drug release rate controlling capacities. Since these are biodegradable and might be utilized as an option in contrast to standard manufactured synthetic and semisynthetic polymers. The isolated biopolymer shows critical biodegradable, mucoadhesive, filmability, and retardability properties which are like properties of standard polymers, may be the alternative in design of novel drug delivery system design

NATIONAL CONFERENCE ON RECENT ADVANCES IN DRUG DISCOVERY AND DEVELOPMENT

<p>NATIONAL CONFERENCE ON RECENT ADVANCES IN DRUG DISCOVERY AND DEVELOPMENT</p><p>https://www.researcherforce.com/conferences</p&gt

Role of surface nanocrystallization on corrosion properties of low carbon steel during surface mechanical attrition treatment

Surface mechanical attrition treatment (SMAT) was carried out on low carbon steel (LCS) by varying ball size from 4 to 8 mm diameter. Present work studies the effect of ball size on the electrochemical behaviour of the LCS in 3.5 wt.% NaCl solution, using open circuit potential (OCP), impedance (EIS) and anodic polarization methods. The untreated LCS shows similar to 29 nm grain size, whereas after SMAT with 4 mm ball size exhibited remarkable reduction in grain size i.e., similar to 11 nm. Reduction in grain size was achieved due to the presence of highly densified mechanical twins after SMAT as well as the formation of dislocation tangles that rearrange themselves into nanocrystallites. These factors have a direct impact on the corrosion behaviour of SMATed LCS. The increase in corrosion potential (E-corr) towards positive side and a reduction of 93% in corrosion current density (i(corr)) value were observed after SMAT using 4 mm balls as compared to the untreated LCS. Remarkable improvement in corrosion resistance was due to grain refinement after SMAT processing, hindrance of the corrosive ion, increase in the activity of charge carriers at the interface between solution and substrate, and reduction in surface roughness. Nanocrystalline surface after SMAT effectively hindered the chloride infiltration into the substrate and resisted pit formation, thus the corrosion performance is improved

Investigation of crystallinity, mechanical properties, fracture toughness and cell proliferation in plasma sprayed graphene nano platelets reinforced hydroxyapatite coating

Graphene nanoplatelets (GNPs) (0, 1 wt% and 2 wt%) reinforced hydroxyapatite (HA), denoted by HA, HA-1G and HA-2G respectively, coatings were fabricated on titanium substrate (Ti-6Al-4V) through atmospheric plasma spraying. The major parameters such as porosity, crystallinity, mechanical properties, toughness and cell proliferation were manipulated by varying plasma power from 15 kW to 35 kW and content of GNPs. For the coating synthesized at all plasma power, GNPs were found to be retained by Raman spectroscopy. GNPs reinforcement has led to an improvement in the crystallinity of the composite coatings as compared to HA coatings. On the contrary to it, increase in plasma power from 15 kW to 35 kW resulted in decrease in crystallinity for all three individual coating. Further, Increment in plasma power from 15 kW to 35 kW delivered a significant enhancement in hardness, elastic modulus and fracture toughness up to 81%, 149% and 282% respectively for HA-1 wt% GNPs coating, while it improved to 20%, 50% and 173% respectively on the addition of 2 wt% GNPs in HA coating fabricated at 35 kW. Enhancement in hardness, elastic modulus and fracture toughness was due to three simultaneous reasons: (1) Reduction in porosity (2) Uniform dispersion of GNPs and (3) Toughening mechanism offered by GNPs. Further, the addition of GNPs showed a remarkable improvement in the rate of cell proliferation in the HA coating. A detailed discussion over the reasons behind every results have been made profoundly

Evaluation of Botanical Powders for the Management of Rice Weevil (Sitophilus oryzae L. Coleoptera: Curculionidae) in Rupandehi, Nepal

An experiment to manage rice weevil (Sitophilus oryzae L. Coleoptera: Curculionidae) in wheat (Triticum aestivum L. Gramineae) was carried out at Institute of Agriculture and Animal Science (IAAS), Paklihawa Campus, Rupandehi, Nepal. The experiment was conducted under completely randomized design (CRD) with seven treatments viz. neem leaf dust (Azadirachta indica A. Juss) 15 g/kg, tobacco leaf dust (Nicotiana tabacum L.) 10 g/kg, ginger rhizome powder (Zingiber officinale Roscoe) 20 g/kg, garlic cloves powder (Allium sativum L.) 20 g/kg, Sichuan pepper seed powder (Zanthoxylum armatum Roxb.) 10 g/kg, sweet flag rhizome dust (Acorus calamus L.) 5 g/kg, and control with three replication. Result revealed that the highest mortality of weevils was observed in the wheat seed treated with A. calamus (98.33%), followed by N. tabacum (85.67%), A. sativum (73.34%), A. indica (70.67%), Z. armatum (70.34%), and Z. officinale (58.34%). Similarly, the lowest percent weight loss (3.32%) and damage of seed (4.0%) were observed in wheat treated with A. calamus. Moreover, the highest germination (89%) was observed in seeds treated with A. calamus rhizome powder when tested at 90 days after treatment application. Based on weevil mortality and the germination test, it is found that sweet flag rhizome powder is the best treatment against rice weevil followed by tobacco leaf dust and garlic clove powder. Therefore, these botanicals could be one of the effective alternatives for the management of weevil especially to the farmers who do not use chemical insecticides in the rural areas of Nepal