113 research outputs found

    paraVerifier: An automatic framework for proving parameterized cache coherence protocols

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    Abstract. Parameterized verification of cache coherence protocols is an impor-tant but challenging research problem. We present in this paper our automatic framework paraVerifier to handle this problem: (1) it first discovers auxiliary in-variants and the corresponding causal relations between invariants and protocol rules from a small reference instance of the verified protocol; (2) the discovered invariants and causal relations can then be generalized into their parameterized form to automatically construct a formal proof to establish the correctness of the protocol. paraVerifier has been successfully applied to a number of benchmarks.

    HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

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    BACKGROUND: As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data. OBJECTIVE: To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia. DESIGN: Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population. RESULTS: The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates. CONCLUSIONS: Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS

    Bioinorganic Chemistry of Alzheimer’s Disease

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    Measurement of Λ4H\rm ^4_{\Lambda}H and Λ4He\rm ^4_{\Lambda}He binding energy in Au+Au collisions at sNN\sqrt{s_\mathrm{NN}} = 3 GeV

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    Measurements of mass and Λ\Lambda binding energy of Λ4H\rm ^4_{\Lambda}H and Λ4He\rm ^4_{\Lambda}He in Au+Au collisions at sNN=3\sqrt{s_{_{\rm NN}}}=3 GeV are presented, with an aim to address the charge symmetry breaking (CSB) problem in hypernuclei systems with atomic number A = 4. The Λ\Lambda binding energies are measured to be 2.22±0.06(stat.)±0.14(syst.)\rm 2.22\pm0.06(stat.) \pm0.14(syst.) MeV and 2.38±0.13(stat.)±0.12(syst.)\rm 2.38\pm0.13(stat.) \pm0.12(syst.) MeV for Λ4H\rm ^4_{\Lambda}H and Λ4He\rm ^4_{\Lambda}He, respectively. The measured Λ\Lambda binding-energy difference is 0.16±0.14(stat.)±0.10(syst.)\rm 0.16\pm0.14(stat.)\pm0.10(syst.) MeV for ground states. Combined with the γ\gamma-ray transition energies, the binding-energy difference for excited states is 0.16±0.14(stat.)±0.10(syst.)\rm -0.16\pm0.14(stat.)\pm0.10(syst.) MeV, which is negative and comparable to the value of the ground states within uncertainties. These new measurements on the Λ\Lambda binding-energy difference in A = 4 hypernuclei systems are consistent with the theoretical calculations that result in ΔBΛ4(1exc+)ΔBΛ4(0g.s.+)<0\rm \Delta B_{\Lambda}^4(1_{exc}^{+})\approx -\Delta B_{\Lambda}^4(0_{g.s.}^{+})<0 and present a new method for the study of CSB effect using relativistic heavy-ion collisions.Comment: 8 pages, 5 figure
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