Ring-modulator-based RoF system with local SSB modulation and remote carrier reuse

A full-duplex radio-over-fibre (RoF) system based on an integrated silicon ring modulator is proposed and demonstrated. For the downstream link, a coherent dual-wavelength laser source is coupled to a silicon ring modulator in the central office (CO). Since only one of the optical carriers in the dual-wavelength laser source is aligned to the resonance of the ring modulator, a single sideband (SSB) modulated optical downstream signal is obtained, which is able to combat the power fading introduced by the fibre dispersion. Besides, for the upstream link, the unmodulated optical carrier in the SSB-modulated optical downstream signal is reused by using an optical filter in the remote radio head. After being modulated by the upstream data, the optical upstream signal is transmitted back to the CO. A proof-of-concept experiment is carried out. Error vector magnitudes of 21-GHz downstream and 10-GHz upstream signals are measured, which confirms that the proposed architecture is a promising lowcost solution for future high-speed wireless communication systems

Polygenic risk score predicts all-cause death in East Asian patients with prior coronary artery disease

IntroductionCoronary artery disease (CAD) is a highly heritable and multifactorial disease. Numerous genome-wide association studies (GWAS) facilitated the construction of polygenic risk scores (PRS) for predicting future incidence of CAD, however, exclusively in European populations. Furthermore, identifying CAD patients with elevated risks of all-cause death presents a critical challenge in secondary prevention, which will contribute largely to reducing the burden for public healthcare.MethodsWe recruited a cohort of 1,776 Chinese CAD patients and performed medical follow-up for up to 11 years. A pruning and thresholding method was used to calculate PRS of CAD and its 14 risk factors. Their correlations with all-cause death were computed via Cox regression.Results and discussionWe found that the PRS for CAD and its seven risk factors, namely myocardial infarction, ischemic stroke, angina, heart failure, low-density lipoprotein cholesterol, total cholesterol and C-reaction protein, were significantly associated with death (P ≤ 0.05), whereas the PRS of body mass index displayed moderate association (P < 0.1). Elastic-net Cox regression with 5-fold cross-validation was used to integrate these nine PRS models into a meta score, metaPRS, which performed well in stratifying patients at different risks for death (P < 0.0001). Combining metaPRS with clinical risk factors further increased the discerning power and a 4% increase in sensitivity. The metaPRS generated from the genetic susceptibility to CAD and its risk factors can well stratify CAD patients by their risks of death. Integrating metaPRS and clinical risk factors may contribute to identifying patients at higher risk of poor prognosis

Full-duplex analog radio-over-fiber system based on an integrated transceiver with a silicon microring modulator and a transfer-printed III-V photodetector

A full-duplex analog radio-over-fiber (RoF) system based on an integrated transceiver is proposed. The transceiver incorporates a C-band silicon microring modulator for the electrical-to-optical (E-O) conversion of the downstream signal and an O-band III-V photodetector (PD) is transfer printed onto the same chip for the optical-to-electrical (O-E) conversion of the upstream signal. With the integrated transceiver, a proof-of-concept experiment is carried out. An error vector magnitude (EVM) less than 6 % is achieved in the X-band for a 1-Gbps 16QAM-modulated signal transmitted through 5-km single mode fiber. Keywords: radio transceivers, microwave photonics, silicon photonics, photodetector

Microwave Photonic Imaging Radar with a Millimeter-level Resolution

Microwave photonic radars enable fast or even real-time high-resolution imaging thanks to its broad bandwidth. Nevertheless, the frequency range of the radars usually overlaps with other existed radio-frequency (RF) applications, and only a centimeter-level imaging resolution has been reported, making them insufficient for civilian applications. Here, we propose a microwave photonic imaging radar with a millimeter-level resolution by introducing a frequency-stepped chirp signal based on an optical frequency shifting loop. As compared with the conventional linear-frequency modulated (LFM) signal, the frequency-stepped chirp signal can bring the system excellent capability of anti-interference. In an experiment, a frequency-stepped chirp signal with a total bandwidth of 18.2 GHz (16.9 to 35.1 GHz) is generated. Postprocessing the radar echo, radar imaging with a two-dimensional imaging resolution of ~8.5 mm$\times$~8.3 mm is achieved. An auto-regressive algorithm is used to reconstruct the disturbed signal when a frequency interference exists, and the high-resolution imaging is sustained

The Multimodal Information based Speech Processing (MISP) 2022 Challenge: Audio-Visual Diarization and Recognition

The Multi-modal Information based Speech Processing (MISP) challenge aims to extend the application of signal processing technology in specific scenarios by promoting the research into wake-up words, speaker diarization, speech recognition, and other technologies. The MISP2022 challenge has two tracks: 1) audio-visual speaker diarization (AVSD), aiming to solve ``who spoken when'' using both audio and visual data; 2) a novel audio-visual diarization and recognition (AVDR) task that focuses on addressing ``who spoken what when'' with audio-visual speaker diarization results. Both tracks focus on the Chinese language, and use far-field audio and video in real home-tv scenarios: 2-6 people communicating each other with TV noise in the background. This paper introduces the dataset, track settings, and baselines of the MISP2022 challenge. Our analyses of experiments and examples indicate the good performance of AVDR baseline system, and the potential difficulties in this challenge due to, e.g., the far-field video quality, the presence of TV noise in the background, and the indistinguishable speakers.Comment: 5 pages, 4 figures, to be published in ICASSP202

Proteomic profiling of eIF3a conditional knockout mice

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is the largest subunit of the eukaryotic translation initiation factor 3 (eIF3). eIF3a plays an integral role in protein biosynthesis, hence impacting the onset, development, and treatment of tumors. The proteins regulated by eIF3a are still being explored in vivo. In this study, a Cre-loxP system was used to generate eIF3a conditional knockout mice. Tandem mass tag (TMT) labeling with LC-MS/MS analysis was used to identify differentially expressed proteins (DEPs) in fat, lungs, skin, and spleen tissue of the eIF3a knockout mice and controls. Bioinformatics analysis was then used to explore the functions and molecular signaling pathways of these protein landscapes. It was observed that eIF3a is essential for life sustenance. Abnormal tissue pathology was found in the lungs, fat, skin, spleen, and thymus. In total, 588, 210, 324, and 944 DEPs were quantified in the lungs, fat, skin, and spleen, respectively, of the eIF3a knockout mice as compared to the control. The quantified differentially expressed proteins were tissue-specific, except for eight proteins shared by the four tissues. A broad range of functions for eIF3a, including cellular signaling pathway, immune response, metabolism, defense response, phagocytes, and DNA replication, has been revealed using bioinformatics analysis. Herein, several pathways related to oxidative stress in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, including nitrogen metabolism, peroxisome, cytochrome P450 drug metabolism, pyruvate metabolism, PPAR signaling pathway, phospholipase D signaling pathway, B-cell receptor signaling pathway, ferroptosis, and focal adhesion, have been identified. Collectively, this study shows that eIF3a is an essential gene for sustaining life, and its downstream proteins are involved in diverse novel functions beyond mRNA translational regulation