Evaluation of the antibacterial activity of Elsholtzia ciliate essential oil against halitosis-related Fusobacterium nucleatum and Porphyromonas gingivalis

The broad-spectrum antimicrobial activity of Elsholtzia ciliate essential oil (ECO) has been previously reported, but its effectiveness against halitosis-causing bacteria such as Fusobacterium nucleatum and Porphyromonas gingivalis is not well understood. In this study, we investigated the bacteriostatic activity of ECO against planktonic cells and biofilms of F. nucleatum and P. gingivalis, as well as its ability to inhibit bacterial metabolism and production of volatile sulfur compounds (VSCs) at sub-lethal concentrations. Our findings revealed that ECO exhibited comparable activities to chlorhexidine against these oral bacteria. Treatment with ECO significantly reduced the production of VSCs, including hydrogen sulfide, dimethyl disulfide, and methanethiol, which are major contributors to bad breath. As the major chemical components of ECO, carvacrol, p-cymene, and phellandrene, were demonstrated in vitro inhibitory effects on F. nucleatum and P. gingivalis, and their combined use showed synergistic and additive effects, suggesting that the overall activity of ECO is derived from the cumulative or synergistic effect of multiple active components. ECO was found to have a destructive effect on the bacterial cell membrane by examining the cell morphology and permeability. Furthermore, the application of ECO induced significant changes in the bacterial composition of saliva-derived biofilm, resulting in the elimination of bacterial species that contribute to halitosis, including Fusobacterium, Porphyromonas, and Prevotella. These results provide experimental evidence for the potential clinical applications of ECOs in the prevention and treatment of halitosis

Do Social Pension Schemes Promote the Mental Health of Rural Middle-Aged and Old Residents? Evidence From China

As China experiences rapid aging, the mental health of older rural adults has become a major public health concern. Among other social insurance programs, the New Rural Social Pension (NRSP) scheme was established to replace part of the income for old-age rural residents in China. This article employs survey data from the China Health and Retirement Longitudinal Study (CHARLS) in 2015 and 2018 to investigate the impact of a pension on depression in middle-aged and old residents. Our results show that the pension scheme not only reduces the depressive symptoms of the rural residents but keeps down the prevalence rate of depression. Among the subscribers of the pension scheme, the pensioners benefit more from enrolling in the pension scheme than the contributors in terms of depression alleviation. The impact of pension on depression displays heterogeneity; female residents, residents in central China, and/or those from lower income households are found to be positively affected. It is also confirmed that a pension scheme contributes to easing depression via reduced labor supply, better family support, and more consumption expenditure

Chaerilus pseudoconchiformus sp. n. and an updated key of the chaerilid scorpions from China (Scorpiones, Chaerilidae) Launched to accelerate biodiversity research

Abstract A new species, C. pseudoconchiformus sp. n., is described from Xizang, China. The new species is distinguished from its congeners by a body length of 32−40 mm, carapace with the anterior margin straight, chela with length/width ratio average of 3.3 in males (3.2−3.4, two adults), and 2.5 in females (2.3−2.6, nine adults), eight or nine (eight usually) rows of denticles on fixed and movable fingers of pedipalp chelae, five pectinal teeth in males and three or four in females. To date, the chaerilid species fauna of China consists of nine species. An updated identification key to Chaerilus from China is presented

Chaerilus pseudoconchiformus sp. n. and an updated key of the chaerilid scorpions from China (Scorpiones, Chaerilidae)

A new species, C. pseudoconchiformus sp. n., is described from Xizang, China. The present new species is distinguished from its congeners by a body length of 32−40 mm, carapace with the anterior margin straight, chela with length/width ratio average of 3.3 in males (3.2−3.4, two adults), and 2.5 in females (2.3−2.6, nine adults), eight or nine (eight usually) rows of denticles on fixed and movable fingers of pedipalp chelae, five pectinal teeth in males and three or four in females. To date, the chaerilid species fauna of China consists of nine species. An updated identification key to Chaerilus from China is presented

Scorpiops ingens sp. n. and an updated key to the Scorpiops from China (Scorpiones, Euscorpiidae, Scorpiopinae)

A new species, Scorpiops ingens sp. n., from Xizang, is described and illustrated. Scorpiops ingens sp. n. is characterized by yellow-brown color, large size (length of adults above 70.0 mm), small and dense granules on tegument, a pair of small median eyes, 17 external trichobothria (5 eb, 2 esb, 2 em, 4 est, 4 et), and 7 or 8 (usually 7) ventral trichobothria in the pedipalp patella, chela with a length/width ratio average of 2.2 in males and females, pedipalp chela fingers on adult females and males scalloped, pectinal teeth count 6–8, pectinal fulcra absent. With the description of this new species, the number of known species of Scorpiops from China is raised to 12. An updated identification key to Scorpiops from China is presented

Adsorption of phenolic contaminants from water on activated carbon: An insight into single and multicomponent adsorption isotherms

The study focuses on the single and multicomponent adsorption of phenolic compounds from solution onto an activated carbon in the concentration range of 50-500 ppm at room temperature. The observed adsorption isotherms were correlated using various predictive and nonpredictive single and multicomponent adsorption isotherm equations. A strong influence of interadsorbate repulsion was evident based on the model proposed using Nitta's adsorption isotherm model

Sensitive and Selective Bacterial Detection Using Tetracysteine-Tagged Phages in Conjunction with Biarsenical Dye

National Natural Science Foundation of China[20675070, 20975087, 90913015, 21027010]; Program for New Century Excellent Talents in University[NCET-07-0729]; Research Funds for the Doctoral Program of Higher Education of China[20090121120008, 20090121110009]; NFFTBS[J1030415

BCR-ABL1 is a secondary event after JAK2V617F in a patient with essential thrombocythemia who develop chronic myeloid leukemia

Several cases such as myeloproliferative neoplasms (MPN) with the coexistence of JAK2 and BCR-ABL have been reported. However, cases of transformation of essential thrombocythemia (ET) into chronic myeloid leukemia (CML) during the disease progression were rarely reported. Here, we report the case of a patient with JAK2 V617F- positive ET who subsequently acquired BCR–ABL1, which transformed the disease into CML after 10 years from the initial diagnosis. In this study, we dynamically monitored JAK2 V617F and BCR-ABL and observed multiple gene mutations, including IDH2, IDH1, ASXL1, KRAS, and RUNX1. It is important to be aware of this potentially clone evolution in disease progression

Machine learning-guided design and development of metallic structural materials

In recent years, the advent of machine learning (ML) in materials science has provided a new tool for accelerating the design and discovery of new materials with a superior combination of mechanical properties for structural applications. In this review, we provide a brief overview of the current status of the ML-aided design and development of metallic alloys for structural applications, including high-performance copper alloys, nickel- and cobalt-based superalloys, titanium alloys for biomedical applications and high strength steel. We also present our perspectives regarding the further acceleration of data-driven discovery, development, design and deployment of metallic structural materials and the adoption of ML-based techniques in this endeavor