Unselective regrowth of 1.5-μm InGaAsP multiple-quantum-well distributed-feedback buried heterostructure lasers

Unselective regrowth for fabricating 1.5-μm InGaAsP multiple-quantum well (MQW) distributed-feedback (DFB) buried heterostructure (BH) lasers is developed. The experimental results exhibit superior characteristics, such as a low threshold of 8.5mA, high slope efficiency of 0.55mW∕mA, circular-like far-field patterns, the narrow linewidth of 2.5MHz, etc. The high performance of the devices effectively proves the feasibility of the new method to fabricate buried heterostructure lasers

Model estimation of cerebral hemodynamics between blood flow and volume changes: a data-based modeling approach

It is well known that there is a dynamic relationship between cerebral blood flow (CBF) and cerebral blood volume (CBV). With increasing applications of functional MRI, where the blood oxygen-level-dependent signals are recorded, the understanding and accurate modeling of the hemodynamic relationship between CBF and CBV becomes increasingly important. This study presents an empirical and data-based modeling framework for model identification from CBF and CBV experimental data. It is shown that the relationship between the changes in CBF and CBV can be described using a parsimonious autoregressive with exogenous input model structure. It is observed that neither the ordinary least-squares (LS) method nor the classical total least-squares (TLS) method can produce accurate estimates from the original noisy CBF and CBV data. A regularized total least-squares (RTLS) method is thus introduced and extended to solve such an error-in-the-variables problem. Quantitative results show that the RTLS method works very well on the noisy CBF and CBV data. Finally, a combination of RTLS with a filtering method can lead to a parsimonious but very effective model that can characterize the relationship between the changes in CBF and CBV

Does Treewidth Help in Modal Satisfiability?

Many tractable algorithms for solving the Constraint Satisfaction Problem (CSP) have been developed using the notion of the treewidth of some graph derived from the input CSP instance. In particular, the incidence graph of the CSP instance is one such graph. We introduce the notion of an incidence graph for modal logic formulae in a certain normal form. We investigate the parameterized complexity of modal satisfiability with the modal depth of the formula and the treewidth of the incidence graph as parameters. For various combinations of Euclidean, reflexive, symmetric and transitive models, we show either that modal satisfiability is FPT, or that it is W[1]-hard. In particular, modal satisfiability in general models is FPT, while it is W[1]-hard in transitive models. As might be expected, modal satisfiability in transitive and Euclidean models is FPT.Comment: Full version of the paper appearing in MFCS 2010. Change from v1: improved section 5 to avoid exponential blow-up in formula siz

Experimental Evidence for a Spin-Polarized Ground State in the \nu=5/2 Fractional Quantum Hall Effect

We study the \nu=5/2 even-denominator fractional quantum Hall effect (FQHE) over a wide range of magnetic (B) field in a heterojunction insulated gate field-effect transistor (HIGFET). The electron density can be tuned from n=0 to 7.6 \times 10^{11} cm^{-2} with a peak mobility \mu = 5.5 \times 10^6 cm^2/Vs. The \nu=5/2 state shows a strong minimum in diagonal resistance and a developing Hall plateau at magnetic fields as high as 12.6T. The strength of the energy gap varies smoothly with B-field. We interpret these observations as strong evidence for a spin-polarized ground state at \nu=5/2.Comment: new references adde

The signals of FGFs on the neurogenesis of embryonic stem cells

<p>Abstract</p> <p>Background</p> <p>Neural induction is a complex process and the detailed mechanism of FGF-induced neurogenesis remains unclear.</p> <p>Methods</p> <p>By using a serum-free neural induction method, we showed that FGF1 dose-dependently promoted the induction of Sox1/N-cadherin/nestin triple positive cells, which represent primitive neuroblasts, from mouse embryonic stem (ES) cells.</p> <p>Results</p> <p>We demonstrated that FGF1, FGF2, and FGF4, but not FGF8b, enhanced this neurogenesis. Especially, FGF-enhanced neurogenesis is not mediated through the rescue of the apoptosis or the enhancement of the proliferation of Sox1⁺cells. We further indicated that the inactivation of c-Jun N-terminal kinase-1 (JNK-1) and extracellular signal-related kinase-2 (ERK-2), but not p38 mitogen-activated protein kinase (MAPK), inhibited the neural formation through the inhibition of ES differentiation, but not through the formation of endomesodermal cells.</p> <p>Conclusions</p> <p>These lines of evidence delineated the roles of FGF downstream signals in the early neural differentiation of ES cells.</p

Inherent Inhomogeneities in Tunneling Spectra of BSCCO Crystals in the Superconducting State

Scanning Tunneling Spectroscopy on cleaved BSCCO(2212) single crystals reveal inhomogeneities on length-scales of $\sim$30 $\AA$. While most of the surface yields spectra consistent with a d-wave superconductor, small regions show a doubly gapped structure with both gaps lacking coherence peaks and the larger gap having a size typical of the respective pseudo-gap for the same sample.Comment: 4 pages, 4 figure

Mixed States of Composite Fermions Carrying Two and Four Vortices

There now exists preliminary experimental evidence for some fractions, such as $\nu$ = 4/11 and 5/13, that do not belong to any of the sequences $\nu=n/(2pn\pm 1)$, $p$ and $n$ being integers. We propose that these states are mixed states of composite fermions of different flavors, for example, composite fermions carrying two and four vortices. We also obtain an estimate of the lowest-excitation dispersion curve as well as the transport gap; the gaps for 4/11 are smaller than those for 1/3 by approximately a factor of 50.Comment: Accepted for PRB rapid communication (scheduled to appear in Nov 15, 2000 issue

Masses of composite fermions carrying two and four flux quanta: Differences and similarities

This study provides a theoretical rationalization for the intriguing experimental observation regarding the equality of the normalized masses of composite fermions carrying two and four flux quanta, and also demonstrates that the mass of the latter type of composite fermion has a substantial filling factor dependence in the filling factor range $4/17 > \nu > 1/5$, in agreement with experiment, originating from the relatively strong inter-composite fermion interactions here.Comment: 5 pages, 2 figure

Correlations Between Charge Ordering and Local Magnetic Fields in Overdoped YBa2_2Cu3_3O6+x_{6+x}

Zero-field muon spin relaxation (ZF-$\mu$SR) measurements were undertaken on under- and overdoped samples of superconducting YBa$_2$Cu$_3$O$_{6+x}$ to determine the origin of the weak static magnetism recently reported in this system. The temperature dependence of the muon spin relaxation rate in overdoped crystals displays an unusual behavior in the superconducting state. A comparison to the results of NQR and lattice structure experiments on highly doped samples provides compelling evidence for strong coupling of charge, spin and structural inhomogeneities.Comment: 4 pages, 4 figures, new data, new figures and modified tex

Ccaat/enhancer-binding protein delta (C/ebpδ): A previously unrecognized tumor suppressor that limits the oncogenic potential of pancreatic ductal adenocarcinoma cells

CCAAT/enhancer-binding protein δ (C/EBPδ) is a transcription factor involved in growth arrest and differentiation, which has consequently been suggested to harbor tumor suppressive activities. However, C/EBPδ over-expression correlates with poor prognosis in glioblastoma and promotes genomic instability in cervical cancer, hinting at an oncogenic role of C/EBPδ in these contexts. Here, we explore the role of C/EBPδ in pancreatic cancer. We determined C/EBPδ expression in biopsies from pancreatic cancer patients using public gene-expression datasets and in-house tissue microarrays. We found that C/EBPδ is highly expressed in healthy pancreatic ductal cells but lost in pancreatic ductal adenocarcinoma. Furthermore, loss of C/EBPδ correlated with increased lymph node involvement and shorter overall survival in pancreatic ductal adenocarcinoma patients. In accordance with this, in vitro experiments showed reduced clonogenic capacity and proliferation of pancreatic ductal adenocarcinoma cells following C/EBPδ re-expression, concurrent with decreased sphere formation capacity in soft agar assays. We thus report a previously unrecognized but important tumor suppressor role of C/EBPδ in pancreatic ductal adenocarcinoma. This is of particular interest since only few tumor suppressors have been identified in the context of pancreatic cancer. Moreover, our findings suggest that restoration of C/EBPδ activity could hold therapeutic value in pancreatic ductal adenocarcinoma, although the latter claim needs to be substantiated in future studies