281 research outputs found
Team Electronic Gameplay Combining Different Means of Control
Disclosed are methods and apparatuses provided for modifying the effect of an operator controlled input device on an interactive device to encourage the self-regulation of at least one physiological activity by a person different than the operator. The interactive device comprises a display area which depicts images and apparatus for receiving at least one input from the operator controlled input device to thus permit the operator to control and interact with at least some of the depicted images. One effect modification comprises measurement of the physiological activity of a person different from the operator, while modifying the ability of the operator to control and interact with at least some of the depicted images by modifying the input from the operator controlled input device in response to changes in the measured physiological signal
Validation of the Pandemic Emotional Impact Scale
Objective The COVID-19 pandemic represents the most universal shared stressor for the general United States (U.S) population in many decades. Due to the unprecedented circumstances of COVID-19, no existing questionnaires can comprehensively measure the multi-faceted psychological effects attributable to this health crisis. This study aimed to validate a measure for that purpose. Methods A 16-item questionnaire, the Pandemic Emotional Impact Scale (PEIS), was designed and subjected to initial validation in an internet survey completed by a nationally representative sample of 1500 adults living in the U.S. This survey was completed between May 18 and May 30, 2020, during the height of the pandemic’s impact on society. Results The PEIS demonstrated excellent internal consistency (Cronbach’s α ​= ​0.94) and Guttman split-half reliability (0.95). Exploratory factor analysis suggested two sub-scales -- emotional impact and pragmatic worries -- but these were highly correlated with the overall scale score suggesting that the total score can be used in most cases. The PEIS demonstrated good concurrent validity via robust positive correlations with anxiety, depression and stress, and negative correlations with quality of life and happiness. Criterion validity was supported by the finding that individuals who reported employment loss or loss of income due to the pandemic, had experienced COVID-19 infection in their household, or knew somebody personally who died from the pandemic, had elevated scores on the PEIS. Conclusions The PEIS questionnaire is a reliable and valid instrument that addresses a significant unmet need for a research instrument that can comprehensively measure pandemic-related effects on the emotional wellbeing of individuals in the U.S population
Systems biology of stored blood cells: can it help to extend the expiration date?
Efst á sÃðunni er hægt að nálgast greinina à heild sinni með þvà að smella á hlekkinnWith increasingly stringent regulations regarding deferral and elimination of blood donors it will become increasingly important to extend the expiration date of blood components beyond the current allowed storage periods. One reason for the storage time limit for blood components is that platelets and red blood cells develop a condition called storage lesions during their storage in plastic blood containers. Systems biology provides comprehensive bio-chemical descriptions of organisms through quantitative measurements and data integration in mathematical models. The biological knowledge for a target organism can be translated in a mathematical format and used to compute physiological properties. The use of systems biology represents a concrete solution in the study of blood cell storage lesions, and it may open up new avenues towards developing better storage methods and better storage media, thereby extending the storage period of blood components. This article is part of a Special Issue entitled: Integrated omics.info:eu-repo/grantAgreement/EC/FP7/23281
Psychological Treatments in Functional Gastrointestinal Disorders: A Primer for the Gastroenterologist
The functional gastrointestinal disorders (FGIDs) often show inadequate response to usual medical care. Psychological treatments can help improve FGID patient outcomes, and such treatment should be considered for patients who have moderate or severe symptoms after 3 to 6 months of medical care, and those whose symptoms are clearly exacerbated by stress or emotional symptoms. Effective psychological treatments, based on multiple randomized controlled trials, include cognitive behavioral therapy (CBT) and hypnosis for irritable bowel syndrome and pediatric functional abdominal pain; CBT for functional chest pain; and biofeedback for dyssynergic constipation in adults. Successful referral by the gastroenterologist for psychological treatment is facilitated by educating the patient about the rationale for such treatment, reassurance about the diagnosis and continuation of medical care, firm doctor-patient therapeutic alliance, and identification of, and communication with, an appropriate psychological services provider
Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?
AbstractBackground & Aims: Comorbid or extraintestinal symptoms occur frequently with irritable bowel syndrome and account for up to three fourths of excess health care visits. This challenges the assumption that irritable bowel is a distinct disorder. The aims of this study were to (1) assess comorbidity in 3 areas: gastrointestinal disorders, psychiatric disorders, and nongastrointestinal somatic disorders; and (2) evaluate explanatory hypotheses. Methods: The scientific literature since 1966 in all languages cited in Medline was systematically reviewed. Results: Comorbidity with other functional gastrointestinal disorders is high and may be caused by shared pathophysiological mechanisms such as visceral hypersensitivity. Psychiatric disorders, especially major depression, anxiety, and somatoform disorders, occur in up to 94%. The nongastrointestinal nonpsychiatric disorders with the best-documented association are fibromyalgia (median of 49% have IBS), chronic fatigue syndrome (51%), temporomandibular joint disorder (64%), and chronic pelvic pain (50%). Conclusions: Multivariate statistical analyses suggest that these are distinct disorders and not manifestations of a common somatization disorder, but their strong comorbidity suggests a common feature important to their expression, which is most likely psychological. Some models explain the comorbidity of irritable bowel with other disorders by suggesting that each disorder is the manifestation of varying combinations of interacting physiological and psychological factors. An alternative hypothesis is that the irritable bowel diagnosis is applied to a heterogeneous group of patients, some of whom have a predominantly psychological etiology, whereas others have a predominantly biological etiology, and that the presence of multiple comorbid disorders is a marker for psychological influences on etiology.GASTROENTEROLOGY 2002;122:1140-115
Method and Apparatus for Performance Optimization Through Physical Perturbation of Task Elements
The invention is an apparatus and method of biofeedback training for attaining a physiological state optimally consistent with the successful performance of a task, wherein the probability of successfully completing the task is made is inversely proportional to a physiological difference value, computed as the absolute value of the difference between at least one physiological signal optimally consistent with the successful performance of the task and at least one corresponding measured physiological signal of a trainee performing the task. The probability of successfully completing the task is made inversely proportional to the physiological difference value by making one or more measurable physical attributes of the environment in which the task is performed, and upon which completion of the task depends, vary in inverse proportion to the physiological difference value
Comparison of aneroid and oscillometric blood pressure measurements in children.
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This article is open access.Limited data exist on the comparison of blood pressure (BP) measurements using aneroid and oscillometric devices. The purpose of the study was to investigate the difference in BP obtained using oscillometric and aneroid BP monitors in 9- to 10-year-old children. A total of 979 children were divided into group O, which underwent two oscillometric BP readings followed by two aneroid readings, and group A, which had BP measured in the reverse order. No significant difference was found between the mean (±standard deviation) of the two systolic BP readings obtained using the oscillometric and aneroid devices (111.5±8.6 vs 111.3±8.1 mm Hg; P=.39), whereas the mean diastolic BP was lower with the oscillometric monitor (61.5±8.0 vs 64.5±6.8 mm Hg; P<.001). A significant downward trend in BP was observed with each consecutive measurement, and agreement between the two monitors was limited. Multiple BP measurements are, therefore, recommended before the diagnosis of elevated BP or hypertension is made with either method.Landspitali - The National University Hospital of Iceland Research Fun
Impact of nephrolithiasis on kidney function.
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This article is open access.Kidney stone disease has been associated with reduced kidney function and chronic kidney disease (CKD). The objective of the study was to examine kidney function, body mass index (BMI) and the prevalence of cardiovascular disease, hypertension and diabetes in recurrent kidney stone formers.A cross-sectional, case-control study comparing measures of kidney function, BMI and comorbid conditions was conducted in 195 kidney stone patients aged 18 to 70 years with recurrent clinical stone events and 390 age- and gender-matched controls. Wilcoxon-Mann-Whitney, chi-square tests and analysis of covariance were used to compare serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) between the groups.The median age of stone formers was 51 (range, 19-70) years and 108 (55 %) were males. Seventy patients (36 %) had experienced 2-4 clinical stone events, 41 (21 %) 5-10 episodes and 84 (43 %) more than 10. The median SCr was 75 (41-140) μmol/L in the stone formers and 64 (34-168) μmol/L in the control group (p < 0.001). The mean eGFR was 87 ± 20 and 104 ± 22 mL/min/1.73 m(2) in the stone formers and controls, respectively (p < 0.001). After adjustment for body size and comorbid conditions, the difference in SCr and eGFR between cases and controls remained highly significant (p < 0.001). The prevalence of CKD was 9.3 % among stone formers compared with 1.3 % in the control group (P < 0.001). Hypertension and diabetes were significantly more prevalent among the cases that also had higher BMI than controls.Recurrent kidney stone formers have a significantly lower level of kidney function and a markedly higher prevalence of CKD than age- and gender-matched control subjects. The observed deleterious effect of kidney stones on kidney function appears to be independent of comorbid conditions.Landspitali University Hospital Research Fun
Incidence of and risk factors of chronic kidney disease: Results of a nationwide study in Iceland
Background - Information on the incidence of chronic kidney disease (CKD) in the general population is scarce. This study examined the incidence and risk factors of CKD stages 1–5 in Iceland, based on multiple markers of kidney damage.
Methods - All serum creatinine (SCr) values, urine protein measurements and diagnosis codes for kidney diseases and comorbid conditions for people aged ≥18 years were obtained from electronic medical records of all healthcare institutions in Iceland in 2008–2016. CKD was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria as evidence for kidney damage and/or estimated glomerular filtration rate (eGFR) 3 months. Alternatively, CKD was defined using age-adapted eGFR thresholds. Mean annual age-standardized incidence of CKD was calculated for persons without CKD at study entry. Risk factor assessment was based on International Classification of Diseases diagnosis codes. Incidence was reported per 100 000 population.
Results - We retrieved 1 820 990 SCr values for 206 727 persons. Median age was 45 years (range, 18–106) and 47% were men. Mean annual age-standardized incidence of CKD per 100 000 was 649 in men and 694 in women, and 480 in men and 522 in women using age-adapted eGFR thresholds. The incidence reached over 3000 in men and women aged >75 years. Traditional CKD risk factors, such as acute kidney injury, diabetes, hypertension and cardiovascular disease, as well as less well characterized risk factors, including chronic lung disease, malignancy and major psychiatric illness were associated with increased risk of CKD, and the same was true for obesity and sleep apnoea in women.
Conclusion - The annual incidence of CKD, with strict adherence to the KDIGO criteria, was <0.7% but markedly lower using age-adapted eGFR thresholds. Apart from acute kidney injury, the observed risk factors comprised chronic and potentially modifiable disorders
Association of eGFR and mortality with use of a joint model: results of a nationwide study in Iceland
Objectives. Prior studies on the association of estimated
glomerular filtration rate (eGFR) and mortality have failed to
include methods to account for repeated eGFR determinations.
The aim of this study was to estimate the association between
eGFR and mortality in the general population in Iceland
employing a joint model.
Methods. We obtained all serum creatinine and urine protein
measurements from all clinical laboratories in Iceland in the
years 2008–16. Clinical data were obtained from nationwide
electronic medical records. eGFR was calculated using the
Chronic Kidney Disease Epidemiology Collaboration equation
and categorized as follows: 0–29, 30–44, 45–59, 60–74, 75–
89, 90–104 and >104 mL/min/1.73 m2. A multiple imputation
method was used to account for missing urine protein
data. A joint model was used to assess risk of all-cause
mortality.
Results. We obtained 2 120 147 creatinine values for 218 437
individuals, of whom 84 364 (39%) had proteinuria measurements available. Median age was 46 (range 18–106) years
and 47% were men. Proteinuria associated with increased
risk of death for all eGFR categories in persons of all
ages. In persons ≤65 years, the lowest risk was observed
for eGFR of 75–89 mL/min/1.73 m2 without proteinuria.
For persons aged >65 years, the lowest risk was observed
for eGFR of 60–74 mL/min/1.73 m2 without proteinuria.
eGFR of 45–59 mL/min/1.73 m2 without proteinuria did not
associate with increased mortality risk in this age group. eGFR
>104 mL/min/1.73 m2 associated with increased mortality.
Conclusions. These results lend further support to the use
of age-adapted eGFR thresholds for defining chronic kidney
disease. Very high eGFR needs to be studied in more detail with
regard to mortalit
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