Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Diseno de un indice sintetico de desarrollo sostenible y aplicacion a la Union Europea

En el presente artículo se establecen las bases metodológicas y se diseña un índice sintético global de desarrollo sostenible que cumple tres condiciones: se adapta a los principios de Presión --Estado-- Respuesta, adopta los mandatos de la Agenda 21 Local y se adecua a los cuatro componentes o dimensiones básicas de la sostenibilidad: institucional, medioambiental, económica y social. A partir de dicha metodología se construye el índice sintético sobre el cómputo de 78 variables, 37 subindicadores y 13 indicadores, agrupados éstos en las cuatro dimensiones citadas para, a continuación, proceder a su aplicación a los países de la UE. Palabras clave: Recursos Naturales, Medio Ambiente, Desarrollo Sostenible, Unión Europea. SUMMARY This article establishes the methodological foundations by designing a global synthetic index of sustainable development which fulfils three conditions: it adapts to the principles of Pressure - State - Response, it adopts the mandates established in Local Agenda 21 and adapts to the four components or basic dimensions of sustainability: institutional, environmental, economic and social. The synthetic index is constructed using the aforesaid methodology and based on the calculations of 78 variables, 37 sub-indicators and 13 indicators, gathered the latter in the previously mentioned four dimensions and subsequently applying this index to the EU countries