711 research outputs found
EFSUMB Recommendations and Guidelines for Gastrointestinal Ultrasound - Part 1: Examination Techniques and Normal Findings (Short version)
Abstract
â–Ľ
In October 2014 the European Federation of Societies
for Ultrasound in Medicine and Biology formed
a Gastrointestinal Ultrasound (GIUS) task force
group to promote the use of GIUS in a clinical setting.
One of the main objectives of the task force
group was to develop clinical recommendations
and guidelines for the use of GIUS under the auspices
of EFSUMB. The first part, gives an overview of
the examination techniques for GIUS recommended
by experts in the field. It also presents the
current evidence for the interpretation of normal
sonoanatomical and physiological features as examined
with different ultrasound modalities
EFSUMB Recommendations and Guidelines for Gastrointestinal Ultrasound - Part 1: Examination Techniques and Normal Findings (Long version).
Abstract
â–Ľ
In October 2014 the European Federation of Societies
for Ultrasound in Medicine and Biology formed
a Gastrointestinal Ultrasound (GIUS) task force
group to promote the use of GIUS in a clinical setting.
One of the main objectives of the task force
group was to develop clinical recommendations
and guidelines for the use of GIUS under the auspices
of EFSUMB. The first part, gives an overview of
the examination techniques for GIUS recommended
by experts in the field. It also presents the
current evidence for the interpretation of normal
sonoanatomical and physiological features as examined
with different ultrasound modalities
EP-2118: CBCT in stereotactic body radiation therapy for lung tumors: manual matching versus auto-matching
The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors
Inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) are considered a promising strategy in cancer immunotherapy as they are able to boost the immune response and to work in synergy with other immunotherapeutic agents. Despite the fact that no IDO1 inhibitor has been approved so far, recent studies have shed light on the additional roles that IDO1 mediates beyond its catalytic activity, conferring new life to the field. Here we present a novel class of compounds originated from a structure-based virtual screening made on IDO1 active site. The starting hit compound is a novel chemotype based on a [1,2,4]triazolo[4,3-a]pyridine scaffold, so far underexploited among the heme binding moieties. Thanks to the rational and in silico-guided design of analogues, an improvement of the potency to sub-micromolar levels has been achieved, with excellent in vitro metabolic stability and exquisite selectivity with respect to other heme-containing enzymes
Introducing Quantum Technologies at Secondary School Level: Challenges and Potential Impact of an Online Extracurricular Course
Stimulated by the European project “QTEdu CSA”, within the flagship “Quantum Technologies”, a community of researchers active in the fields of quantum technologies and physics education has designed and implemented an extracurricular course on quantum physics concepts and quantum technologies applications for high school. The course, which featured eight interactive lectures, was organized online between March and May 2021 and attended by about 250 students from all over Italy. In this paper, we describe the main tenets and activities of the course. Moreover, we report on the effectiveness of the course on students’ knowledge of the basic concepts of quantum physics and students’ views about epistemic aspects and applications of quantum technologies. Results show that the designed activities were effective in improving students’ knowledge about fundamental aspects of quantum mechanics and familiarizing them with quantum technology applications
Measurement of Aerosols at the Pierre Auger Observatory
The air fluorescence detectors (FDs) of the Pierre Auger Observatory are
vital for the determination of the air shower energy scale. To compensate for
variations in atmospheric conditions that affect the energy measurement, the
Observatory operates an array of monitoring instruments to record hourly
atmospheric conditions across the detector site, an area exceeding 3,000 square
km. This paper presents results from four instruments used to characterize the
aerosol component of the atmosphere: the Central Laser Facility (CLF), which
provides the FDs with calibrated laser shots; the scanning backscatter lidars,
which operate at three FD sites; the Aerosol Phase Function monitors (APFs),
which measure the aerosol scattering cross section at two FD locations; and the
Horizontal Attenuation Monitor (HAM), which measures the wavelength dependence
of aerosol attenuation.Comment: Contribution to the 30th International Cosmic Ray Conference, Merida
Mexico, July 2007; 4 pages, 4 figure
Gas Analysis and Monitoring Systems for the RPC Detector of CMS at LHC
The Resistive Plate Chambers (RPC) detector of the CMS experiment at the LHC
proton collider (CERN, Switzerland) will employ an online gas analysis and
monitoring system of the freon-based gas mixture used. We give an overview of
the CMS RPC gas system, describe the project parameters and first results on
gas-chromatograph analysis. Finally, we report on preliminary results for a set
of monitor RPC.Comment: 9 pages, 8 figures. Presented by Stefano Bianco (Laboratori Nazionali
di Frascati dell'INFN) at the IEEE NSS, San Diego (USA), October 200
Engagement of nuclear coactivator 7 by 3-hydroxyanthranilic acid enhances activation of aryl hydrocarbon receptor in immunoregulatory dendritic cells
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first step in the kynurenine pathway of tryptophan (Trp) degradation that produces several biologically active Trp metabolites. L-kynurenine (Kyn), the first byproduct by IDO1, promotes immunoregulatory effects via activation of the Aryl hydrocarbon Receptor (AhR) in dendritic cells (DCs) and T lymphocytes. We here identified the nuclear coactivator 7 (NCOA7) as a molecular target of 3-hydroxyanthranilic acid (3-HAA), a Trp metabolite produced downstream of Kyn along the kynurenine pathway. In cells overexpressing NCOA7 and AhR, the presence of 3-HAA increased the association of the two molecules and enhanced Kyn-driven, AhR-dependent gene transcription. Physiologically, conventional (cDCs) but not plasmacytoid DCs or other immune cells expressed high levels of NCOA7. In cocultures of CD4+ T cells with cDCs, the co-addition of Kyn and 3-HAA significantly increased the induction of Foxp3+ regulatory T cells and the production of immunosuppressive transforming growth factor β in an NCOA7-dependent fashion. Thus, the co-presence of NCOA7 and the Trp metabolite 3-HAA can selectively enhance the activation of ubiquitary AhR in cDCs and consequent immunoregulatory effects. Because NCOA7 is often overexpressed and/or mutated in tumor microenvironments, our current data may provide evidence for a new immune check-point mechanism based on Trp metabolism and AhR
Calibration of the Logarithmic-Periodic Dipole Antenna (LPDA) Radio Stations at the Pierre Auger Observatory using an Octocopter
An in-situ calibration of a logarithmic periodic dipole antenna with a
frequency coverage of 30 MHz to 80 MHz is performed. Such antennas are part of
a radio station system used for detection of cosmic ray induced air showers at
the Engineering Radio Array of the Pierre Auger Observatory, the so-called
Auger Engineering Radio Array (AERA). The directional and frequency
characteristics of the broadband antenna are investigated using a remotely
piloted aircraft (RPA) carrying a small transmitting antenna. The antenna
sensitivity is described by the vector effective length relating the measured
voltage with the electric-field components perpendicular to the incoming signal
direction. The horizontal and meridional components are determined with an
overall uncertainty of 7.4^{+0.9}_{-0.3} % and 10.3^{+2.8}_{-1.7} %
respectively. The measurement is used to correct a simulated response of the
frequency and directional response of the antenna. In addition, the influence
of the ground conductivity and permittivity on the antenna response is
simulated. Both have a negligible influence given the ground conditions
measured at the detector site. The overall uncertainties of the vector
effective length components result in an uncertainty of 8.8^{+2.1}_{-1.3} % in
the square root of the energy fluence for incoming signal directions with
zenith angles smaller than 60{\deg}.Comment: Published version. Updated online abstract only. Manuscript is
unchanged with respect to v2. 39 pages, 15 figures, 2 table
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