102 research outputs found
Insular cortex involvement in declarative memory deficits in patients with post-traumatic stress disorder
Ovarian cancer
Ovarian cancer is not a single disease and can be subdivided into at least five different histological subtypes that have different identifiable risk factors, cells of origin, molecular compositions, clinical features and treatments. Ovarian cancer is a global problem, is typically diagnosed at a late stage and has no effective screening strategy. Standard treatments for newly diagnosed cancer consist of cytoreductive surgery and platinum-based chemotherapy. In recurrent cancer, chemotherapy, anti-angiogenic agents and poly(ADP-ribose) polymerase inhibitors are used, and immunological therapies are currently being tested. High-grade serous carcinoma (HGSC) is the most commonly diagnosed form of ovarian cancer and at diagnosis is typically very responsive to platinum-based chemotherapy. However, in addition to the other histologies, HGSCs frequently relapse and become increasingly resistant to chemotherapy. Consequently, understanding the mechanisms underlying platinum resistance and finding ways to overcome them are active areas of study in ovarian cancer. Substantial progress has been made in identifying genes that are associated with a high risk of ovarian cancer (such as BRCA1 and BRCA2), as well as a precursor lesion of HGSC called serous tubal intraepithelial carcinoma, which holds promise for identifying individuals at high risk of developing the disease and for developing prevention strategies
Effect of glutamine on the total antioxidant system of rats subjected to renal ischemia and reperfusion
Vorinostat enhances the cisplatin-mediated anticancer effects in small cell lung cancer cells
Examining influential factors in providers’ chronic pain treatment decisions: a comparison of physicians and medical students
Procedural Learning and Memory Rehabilitation in Korsakoff’s Syndrome - a Review of the Literature
Retrieval Intention Modulates the Effects of Directed Forgetting Instructions on Recollection
Priority research questions in atopic dermatitis: an International Eczema Council eDelphi consensus
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