The relationship between complications, common knowledge details and self-handicapping strategies and veracity: a meta-analysis

Practitioners frequently inform us that variable ‘total details’ is not suitable for lie detection purposes in real life interviews. Practitioners cannot count the number of details in real time and the threshold of details required to classify someone as a truth teller or a lie teller is unknown. The authors started to address these issues by examining three new verbal veracity cues: complications, common knowledge details, and self-handicapping strategies. We present a meta-analysis regarding these three variables and compared the results with ‘total details’. Truth tellers reported more details (d = 0.28 to d = 0.45) and more complications (d = 0.51 to d = 0.62) and fewer common knowledge details (d = -0.40 to d = -0.46) and self-handicapping strategies (d = -0.37 to d = -0.50) than lie tellers. Complications was the best diagnostic veracity cue. The findings were similar for the initial free recall and the second recall in which only new information was examined. Four moderators (scenario, motivation, modality, and interview technique) did not affect the results. As a conclusion, complications in particular appear to be a good veracity indicator but more research is required. We included suggestions for such research

Detecting Lies via a Theme-Selection Strategy

Most of deception research has focused on past events that were either completely truthful or a complete fabrication. However, people often tell a mixture of truths and lies. This could enable investigators to make within-subjects comparisons between different themes discussed in one interview, which we examined in the current experiment. Seventy-three participants took part in the experiment and were asked to either tell the truth about two themes, or to tell the truth about one theme and lie about the second theme in a HUMINT setting. Results showed that examining the differences in the amount of detail provided by the interviewees for each theme- obtained through a Theme-Selection strategy (a within-subjects measure)- yielded stronger results than examining differences between truth tellers and liars based on the entire interview without accounting for themes (between-subjects measure). The present study therefore highlighted the effectiveness of within-subjects measurements to both discriminate truth tellers from liars and to discover which section of a statement is false

The representation of child–parent relation: validation of the Italian version of the child–parent relationship scale (CPRS-I)

This study proposes a psychometric validation of the Italian version of the Child–Parent Relationship Scale (CPRS) developed by Pianta in 1992. Based on attachment theory, the scale assesses parents’ relationship perceptions with their own child and comprises three scales: Closeness, Conflict, and Dependency. A sample of 501 parents (188 fathers and 313 mothers) completed 30 items of the Italian version of the Child–Parent Relationship Scale (CPRS-I) online, but only 437 answered 85% of the entire protocol; hence, the analyses only focused on 437 participants. The first analysis of the original theoretical model revealed poor fit, item loadings, and internal consistency. Therefore, a follow-up analysis was conducted. Exploratory and confirmatory analyses with a split sample (EFA = 218; CFA = 219) confirmed the original three-factor structure of the Italian sample, although some items were eliminated. The validity and reliability of the Italian version of the CPRS-I were also verified by correlating the above three factors with measures of adult attachment styles and children’s internalizing and externalizing behaviors. The CPRS-I showed significant correlations with all tested constructs, in line with those found by Driscoll and Pianta for the short form of the scale. Our results confirm that the CPRS-I has the same structure as the original scale; therefore, it can be a useful tool for assessing parents’ perceptions of their relationship with their children. The implications for educational and clinical settings are also discussed

Quality of life changes over time and predictors in a large head and neck patients' cohort: secondary analysis from an Italian multi-center longitudinal, prospective, observational study-a study of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) head and neck working group

Purpose: The present study examined the longitudinal trajectories, through hierarchical modeling, of quality of life among patients with head and neck cancer, specifically symptoms burden, during radiotherapy, and in the follow-up period (1, 3, 6, and 12 months after completion of radiotherapy), through the M.D. Anderson Symptom Inventory Head and Neck questionnaire, formed by three factors. Furthermore, analyses were conducted controlling for socio-demographic as well as clinical characteristics. Methods: Multi-level mixed-effects linear regression was used to estimate the association between quality of life and time, age, gender, household, educational level, employment status, ECOG performance status, human papilloma virus (HPV) status, surgery, chemotherapy, alcohol intake, and smoking. Results: Among the 166 participants, time resulted to be a predictor of all the three questionnaire factors, namely, general and specific related symptoms and interference with daily life. Moreover, regarding symptom interference with daily activities factor, HPV-positive status played a significant role. Considering only HPV-negative patients, only time predicted patients' quality of life. Differently, among HPV-positive patients, other variables, such as gender, educational level, alcohol use, surgery, age at diagnosis, employment status, and ECOG status, resulted significant. Conclusion: It was evident that quality of life of patients with head and neck cancer declined during RT, whereas it slowly improved after ending treatment. Our results clarified the role of some socio-demographic and clinical variables, for instance, HPV, which would allow to develop treatments tailored to each patient

Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care

Introduction: This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating the potential of early treatment with oral semaglutide. Methods: A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals with T2D. A scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, and physician judgments on treatment appropriateness. Participants completed anonymous patient questionnaires reflecting routine clinical encounters. The preferred therapeutic regimen for each patient was also identified. Results: The analysis was conducted on 4449 patients initiating oral semaglutide. The population had a relatively short disease duration (42%  60% of patients, and more often than sitagliptin or empagliflozin. Conclusion: The study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Tecniche di interrogatorio con soggetti adulti: una rassegna internazionale

La credibilità della persona sottoposta ad interrogatorio è un tema centrale per l’ambito giudiziario e il cui studio richiede sinergie con altre discipline, in particolare le scienze psicologiche. Infatti in letteratura, soprattutto internazionale, sono di-sponibili diverse tecniche sviluppate a partire da collaborazioni tra mondo della giustizia e psicologia. Lo scopo di questo la-voro è presentare le diverse strategie ad oggi presenti. A tal fine, sono stati passati in rassegna i lavori più recenti, cercando di sottolineare i pro e i contro di ogni tecnica presentata. In conclusione, risultano chiari l’efficacia di alcune di queste ed il beneficio che il loro utilizzo da parte delle forze di polizia potrebbe portare