Association Behavior of Poly(methacrylic acid)-block-Poly(methyl methacrylate) in Aqueous Medium: Potentiometric and Laser Light Scattering Studies

Atom transfer radical polymerisation (ATRP) technique was used to synthesize poly(methacrylic acid-block-methyl methacrylate) (P(MAA₁₀₂-b-MMA₁₀)) copolymer in order to study the aggregation behavior in aqueous solution over the course of neutralization. A combination of static and dynamic light scattering (SLS, DLS) and potentiometric titration techniques were used to investigate the size and shape of the micelle at various degrees of neutralization. The hydrodynamic radius (Rh) determined from dynamic light scattering increases from ~26nm (for unneutralized) to ~42nm (for completely neutralized sample). Both potentiometric and laser light scattering studies indicate the formation of a core shell micelle. The weighted average molecular weights of the polymer and micelle are 1.18x10⁴ and 2.25 x 10⁵ g/mol respectively, which suggests that the aggregation number of the micelle is ~20.Singapore-MIT Alliance (SMA

Phytochemical screening and antibacterial evaluation of stem bark of Mallotus philippinensis var. Tomentosus

Mallotus philippinensis var. Tomentosus is a medicinal plant, which was tested against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi and Bacillus subtilis. Phytochemicalscreening of the stem bark of M. philippinensis indicates the presence of secondary metabolites. From the results obtained, eluted fractions of chloroform and methanolic extracts showed excellent zone of inhibition comparable to the standard drug used. However, the hexane extract did not show any appreciable activity. The results of the study showed the justification of the use of the plant against the bacterial pathogens

Association Behavior of Poly (methyl methacrylate-b-methacrylic acid-b-methyl methacrylate) in Aqueous Medium

ABA type tri-block amphiphilic polyelectrolyte consisting of poly(methyl methacrylate-block-methacrylic acid-block-methyl methacrylate) (P(MMA-b-MAA-b-MMA)) was synthesized by atom transfer radical polymerization technique (ATRP) and the self-assembly behavior of the polymers in aqueous solution was studied over the course of neutralization. Combination of potentiometric and conductometric titrations along with dynamic light scattering (DLS) techniques were used to investigate the size and shape of aggregates at various degrees of neutralization. The effect of hydrophobic-hydrophilic (MMA-MAA) ratio and polymer chain length on the aggregation behavior during neutralization was studied. P(MMA-b-MAA-b-MMA) with longer MMA segment self-assembles via the close association mechanism through stronger self-entanglement of MMA chains, whereas P(MMA-b-MAA-b-MMA) with shorter MMA chain self-assembles via the open association mechanism, as confirmed by transmission electron microscopy (TEM). Conductometric titration was used to determine the counterion condensation during the course of neutralization. When the charge density of micelle approaches a critical value as neutralization progresses, counterion condensation of Na+ ions on the polymer chains occurs. The effect of counterion condensation on the aggregation behavior during neutralization was elucidated.Singapore-MIT Alliance (SMA

Novel pH Responsive Amphiphilic Diblock Copolymers with Reversible Micellization Properties

Di-block copolymer of poly[methacrylic acid-block-2-(diethylamino)ethyl methacrylate] [P(MAA-b-DEA)] with narrow molecular weight distribution was synthesized using the atom transfer radical polymerization (ATRP) technique. The micellization behavior of the P(MAA-b-DEA) copolymer in aqueous solution at room temperature and different pH values were examined by potentiometric and conductivity titration, UV-Visible spectrophotometry, ¹H-NMR, static and dynamic laser light scattering. At low pH ( 9.5), core-shell like micelles consisting of hydrophobic DEA core and ionized MAA shell were re-established.Singapore-MIT Alliance (SMA

Immune Thrombocytopenia in a Challenging Case of Disseminated Tuberculosis: A Case Report and Review of the Literature

Mycobacterium tuberculosis (MTB) continues to predominate the cause of morbidity, and mortality in the developing world. The disease affects all the organ systems, and presents in various pathologic disease states. We report an uncommon manifestation of this rather common infectious disease in a 19-year-old male. Immune-mediated thrombocytopenia occurring as a consequence of the tuberculosis infection itself is an exceedingly rare occurrence, and at the time of writing of this paper, only 15 such published reports exist in the English literature so far

Milestones: a Rapid Assessment Method for the Clinical Competency Committee

INTRODUCTION: Educational milestones are now used to assess the developmental progress of all U.S. graduate medical residents during training. Twice annually, each program\u27s Clinical Competency Committee (CCC) makes these determinations and reports its findings to the Accreditation Council for Graduate Medical Education (ACGME). The ideal way to conduct the CCC is not known. After finding that deliberations reliant upon the new milestones were time intensive, our internal medicine residency program tested an approach designed to produce rapid but accurate assessments. MATERIAL AND METHODS: For this study, we modified our usual CCC process to include pre-meeting faculty ratings of resident milestones progress with in-meeting reconciliation of their ratings. Data were considered largely via standard report and presented in a pre-arranged pattern. Participants were surveyed regarding their perceptions of data management strategies and use of milestones. Reliability of competence assessments was estimated by comparing pre-/post-intervention class rank lists produced by individual committee members with a master class rank list produced by the collective CCC after full deliberation. RESULTS: Use of the study CCC approach reduced committee deliberation time from 25 min to 9 min per resident (p \u3c 0.001). Committee members believed milestones improved their ability to identify and assess expected elements of competency development (p = 0.026). Individual committee member assessments of trainee progress agreed well with collective CCC assessments. CONCLUSIONS: Modification of the clinical competency process to include pre-meeting competence ratings with in-meeting reconciliation of these ratings led to shorter deliberation times, improved evaluator satisfaction and resulted in reliable milestone assessments

NMR metabolomic modeling of age and lifespan: A multicohort analysis.

Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological age (CA), mortality, and age-related disease. Ninety-eight metabolic variables were measured in blood from nine UK and Finnish cohort studies (N ≈31,000 individuals, age range 24-86 years). We used nonlinear and penalized regression to model CA and time to all-cause mortality. We examined associations of four new and two previously published metabolomic age models, with aging risk factors and phenotypes. Within the UK Biobank (N ≈102,000), we tested prediction of CA, incident disease (cardiovascular disease (CVD), type-2 diabetes mellitus, cancer, dementia, and chronic obstructive pulmonary disease), and all-cause mortality. Seven-fold cross-validated Pearson's r between metabolomic age models and CA ranged between 0.47 and 0.65 in the training cohort set (mean absolute error: 8-9 years). Metabolomic age models, adjusted for CA, were associated with C-reactive protein, and inversely associated with glomerular filtration rate. Positively associated risk factors included obesity, diabetes, smoking, and physical inactivity. In UK Biobank, correlations of metabolomic age with CA were modest (r = 0.29-0.33), yet all metabolomic model scores predicted mortality (hazard ratios of 1.01 to 1.06/metabolomic age year) and CVD, after adjustment for CA. While metabolomic age models were only moderately associated with CA in an independent population, they provided additional prediction of morbidity and mortality over CA itself, suggesting their wider applicability

A machine learning classifier for fast radio burst detection at the VLBA

Time domain radio astronomy observing campaigns frequently generate large volumes of data. Our goal is to develop automated methods that can identify events of interest buried within the larger data stream. The V-FASTR fast transient system was designed to detect rare fast radio bursts within data collected by the Very Long Baseline Array. The resulting event candidates constitute a significant burden in terms of subsequent human reviewing time. We have trained and deployed a machine learning classifier that marks each candidate detection as a pulse from a known pulsar, an artifact due to radio frequency interference, or a potential new discovery. The classifier maintains high reliability by restricting its predictions to those with at least 90% confidence. We have also implemented several efficiency and usability improvements to the V-FASTR web-based candidate review system. Overall, we found that time spent reviewing decreased and the fraction of interesting candidates increased. The classifier now classifies (and therefore filters) 80%–90% of the candidates, with an accuracy greater than 98%, leaving only the 10%–20% most promising candidates to be reviewed by humans

Limits on Einstein's equivalence principle from the first localized fast radio burst FRB 150418

Fast radio bursts (FRBs) have recently been used to place limits on Einstein’s Equivalence Principle via observations of time delays between photons of different radio frequencies by Wei et al. These limits on differential post-Newtonian parameters (Δγ < - 2.52 x 10 -8) are the best yet achieved, but they still rely on uncertain assumptions, namely the relative contributions of dispersion and gravitational delays to the observed time delays and the distances to FRBs. Also, very recently, the first FRB host galaxy has likely been identified, providing the first redshift-based distance estimate to FRB 150418. Moreover, consistency between the ΩIGM estimate from FRB 150418 and ΩIGM, expected from ΛCDM models and WMAP observations, leads one to conclude that the observed time delay for FRB 150418 is highly dominated by dispersion, with any gravitational delays being small contributors. This points to even tighter limits on Δγ. In this paper, the technique of Wei et al. is applied to FRB 150418 to produce a limit of Δγ < 1–2 × 10−9, approximately an order of magnitude better than previous limits and in line with expectations by Wei et al. for what could be achieved if the dispersive delay is separated from other effects. Future substantial improvements in such limits will depend on accurately determining the contribution of individual ionized components to the total observed time delays for FRBs

A deep search for prompt radio emission from the short GRB 150424A with the Murchison Widefield Array

© 2015. The American Astronomical Society. All rights reserved. We present a search for prompt radio emission associated with the short-duration gamma-ray burst (GRB) 150424A using the Murchison Widefield Array (MWA) at frequencies from 80 to 133 MHz. Our observations span delays of 23 s-30 minutes after the GRB, corresponding to dispersion measures of 100-7700 pc cm-3. We see no excess flux in images with timescales of 4 s, 2 minutes, or 30 minutes and set a 3ó flux density limit of 3.0 Jy at 132 MHz on the shortest timescales: some of the most stringent limits to date on prompt radio emission from any type of GRB. We use these limits to constrain a number of proposed models for coherent emission from shortduration GRBs, although we show that our limits are not particularly constraining for fast radio bursts because of reduced sensitivity for this pointing. Finally, we discuss the prospects for using the MWA to search for prompt radio emission from gravitational wave (GW) transients and find that while the flux density and luminosity limits are likely to be very constraining, the latency of the GW alert may limit the robustness of any conclusions