Пьеса Т. Мидлтона и У. Роули «Оборотень» как «трагедия порока»

The article is devoted to the consideration of the motif of “lapse from virtue” based on the example of the heroine of the Renaissance revenge tragedy “The Changeling” (1622) by Thomas Middleton and William Rowley. The article identifies the key scenes of the tragedy, helping to understand the multidimensionality and allusiveness of the heroine. In the context of the relationship of the heroine to other characters in the tragedy, the authors determine and analyse the character metamorphosis and stages of the moral decay of Beatrice-Joanna. Examples of the subversion of the audience’s expectation are given. The authors examine scenes of the tragedy, which help to reveal the motifs of the double and shapeshifting, related to the image of the main character. The system of characters in the play by Middleton and Rowley is considered in the context of the most significant dramatic works of the Elizabethan and Jacobean eras.El artículo está dedicado a la consideración del motivo de la caída con el ejemplo de la imagen de la heroína principal de la sangrienta tragedia renacentista de la venganza de T. Middleton y W. Rowley (Thomas Middleton, 1580-1627, y William Rowley, 1585-1626) "El hombre lobo" (1622). El artículo identifica escenas clave del drama que ayudan a comprender la no unidimensionalidad y la alusividad de la imagen del personaje principal. En el contexto de la relación de la heroína con otros personajes del drama, los autores revelan y analizan las metamorfosis del personaje y las etapas de degradación moral de Beatrice-Joanna. Se dan los ejemplos del uso de la recepción del engaño de las expectativas del público. Los autores consideran escenas del texto del drama que ayudan a descubrir los motivos de la dualidad y a trabajar en la imagen del personaje principal. El sistema de personajes de la obra de T. Middleton y W. Rowley se considera en el contexto de las obras dramáticas más llamativas de las épocas Isabelina y Yakoviana.Статья посвящена рассмотрению мотива грехопадения на примере образа главной героини ренессансной кровавой трагедии мести Т. Мидлтона и У. Роули (Thomas Middleton, 1580-1627, and William Rowley, 1585-1626) «Оборотень» («The Changeling», 1622). В статье выявлены ключевые сцены драмы, помогающие понять неодномерность и аллюзивность образа главной героини. В контексте взаимоотношений героини с другими персонажами драмы авторы выявляют и анализируют метаморфозы характера и этапы нравственного разложения Беатрисы-Джоанны. Приведены примеры использования приема обмана зрительских ожиданий. Авторы рассматривают сцены из текста драмы, помогающие раскрыть мотивы двойничества и оборотничества, связанные с образом главной героини. Система персонажей пьесы Т. Мидлтона и У. Роули рассмотрена в контексте наиболее ярких драматических произведений Елизаветинской и Яковианской эпох

Future physical education teachers’ marketing business motivations survey

Objective of the study was to survey marketing business motivations of future physical education teacher

The northeastern Black Sea redox zone: Hydrochemical structure and its temporal variability

Detailed studies of the vertical structure of hydrochemical parameters in the northeastern Black Sea near Gelendzhik are presented and discussed. This work is based on a set of systematic observations carried out in this region during R/V Akvanavt and R/V Ashamba cruises from 1997 to 2005 and also on data from previous studies from 1984 to 1997. The Black Sea region near Gelendzhik is far from the influences of the Bosporus input and Danube River inflow. Therefore, the vertical structure in this region is more stable compared to the western Black Sea and reflects integrated, rather than local, changes of the Black Sea. Seasonal variations in the distribution of chemical parameters at the redox interface are connected to seasonal variations in hydrophysical processes and organic matter production. In winter, maxima of organic phosphorus and urea were absent in the vicinity of the onset of hydrogen sulfide. The concentrations of nitrate were lower in winter than in summer. Winter mixing in the anticyclone eddies led to reduced vertical gradients in the redox layer and to the disappearance of an upper phosphate minimum. Study of the interannual dynamics of oxygen concentrations in the Cold Intermediate Layer and anoxic waters boundary in the density field position revealed climatic-scale changes that may be connected with changes in the North Atlantic Oscillation (NAO) index. © 2006 Elsevier Ltd. All rights reserved

Possibility of using the infrapatellar (Hoffa’s) fat pad as a source of autologous stem cells

Stem cells are the basis for the creation of tissue-engineered structures in regenerative medicine. The most well-studied sources of stem cells are the embryo and bone marrow. The use of embryonic cells is associated with ethical problems, and the collection of bone marrow is accompanied by invasive procedures. Using adipose tissue as a source of stem cells avoids these problems. But the collection of adipose tissue requires additional interventions, which does not exclude the occurrence of cosmetic defects. Aim of the study was to investigate the possibility of using mesenchymal stem cells (MSCs) isolated from the infrapatellar (Hoffa’s) fat pad.Material and methods. As a source of MSCs, tissue samples of Hoffa’s fat pad removed during the operation were used (8 cases), as a control - MSCs isolated from human adipose tissue (6 cases). MSCs were isolated using an enzymatic method. At the 3rd passage, phenotyping with specific antibodies against CD34, CD45, CD73, CD90, CD105 was performed by flow cytometry. Differentiation in the chondro- and osteogenic direction was carried out at the 3rd passage with the appropriate differentiation media. Chondrogenic differentiation was confirmed by staining with alcian blue, osteogenic - staining according to von Kossa.Results and discussion. Statistically significant decrease in CD105 expression, increase in CD73, CD34 expression and lack of adequate differentiation under standard conditions of differentiation media by MSCs isolated from the Hoffa’s fat pad compared to control was found. The data obtained indicate a discrepancy between the cells isolated from the Hoffa’s fat pad and the requirements for MSCs.Conclusion. The infrapatellar (Hoffa’s) fat pad_cannot be used as a source of standardized MSCs

Therapeutic gymnastics and pelotherapy in physical rehabilitation of patients after arthroscopic surgery on the shoulder joint

Objective: to improve the effectiveness of early postoperative rehabilitation of patients after arthroscopic surgery on the shoulder joint by the combined use of exercises with dynamic controlled muscle tension (DCMT) and thin-layer peloidotherapy. Materials and methods: 98 patients operated on for rotator cuff syndrome, were divided into 3 groups, comparable in age, sex and the main clinical manifestations. All patients received basic therapy, including orthopedic mode in the form of immobilization of the upper limb and curative gymnastics according to the standard method. Patients of the I and II group in addition to basic treatment were given an exercise course with dynamic controlled muscle tension during the immobilization and postimmobilization period. Patients of the II main group in the postimmobilization period received pelotherapy. Results: according to the results of goniometry in patients of I and II groups had the greater volume of movement in the shoulder joint after immobilization was stopped in comparison with patients of group III (control). Analysis of pain indicators while the shoulder joint moving on the scale of pain a month after immobilization revealed a significant advantage of the results of the II main group. Conclusions: it was shown that the inclusion of exercises with dynamic controlled muscle tension in the therapeutic complex had a more significant effect on the main clinical symptoms of the disease, the regeneration processes, and also contributed to an earlier restoration of impaired functions of the shoulder joint

Two-particle decays of B_c meson into charmonium states

The factorization of hard and soft contributions into the hadronic decays of B_c meson at large recoils is explored in order to evaluate the decay rates into the S, P and D-wave charmonia associated with rho and pi. The constraints of approach applicability and uncertainties of numerical estimates are discussed. The mode with the J/psi in the final state is evaluated taking into account the cascade radiative electromagnetic decays of excited P-wave states, that enlarges the branching ratio by 20-25%.Comment: 13 pages, LaTeX axodraw-style, 1 figure, 2 table

Prospects for the Bc Studies at LHCb

We discuss the motivations and perspectives for the studies of the mesons of the (bc) family at LHCb. The description of production and decays at LHC energies is given in details. The event yields, detection efficiencies, and background conditions for several Bc decay modes at LHCb are estimated.Comment: 20 pages, 5 eps-figure

Leptonic constants of heavy quarkonia in potential approach of NRQCD

We consider a general scheme for calculating the leptonic constant of heavy quarkonium QQ-bar in the framework of nonrelativistic quantum chromodynamics, NRQCD, operating as the effective theory of nonrelativistic heavy quarks. We explore the approach of static potential in QCD, which takes into account both the evolution of effective charge in the three-loop approximation and the linearly raising potential term, which provides the quark confinement. The leptonic constants of bb-bar and cc-bar systems are evaluated by making use of two-loop anomalous dimension for the current of nonrelativistic quarks, where the factor for the normalization of matrix element is introduced in order to preserve the renormalization group invariance of estimates.Comment: 18 pages, 6 eps-figures, discussion and references added, vNRQCD analysis considere

Gender differences in the pharmacological actions of pegylated glucagon-Like peptide-1 on endothelial progenitor cells and angiogenic precursor cells in a combination of metabolic disorders and lung emphysema

In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little is known about sex-specific differences in the pathogenesis of COPD, especially when combined with MetS. Consequently, it is not clear whether the same treatment regime has comparable efficacy in men and women diagnosed with MetS and COPD. In the present study, using sodium glutamate, lipopolysaccharide, and cigarette smoke extract, we simulated lipid metabolism disorders, obesity, hyperglycemia, and pulmonary emphysema (comorbidity) in male and female C57BL/6 mice. We assessed the gender-specific impact of lipid metabolism disorders and pulmonary emphysema on angiogenic precursor cells (endothelial progenitor cells (EPC), pericytes, vascular smooth muscle cells, cells of the lumen of the nascent vessel), as well as the biological effects of pegylated glucagon-like peptide 1 (pegGLP-1) in this experimental paradigm. Simulation of MetS/COPD comorbidity caused an accumulation of EPC (CD45−CD31+CD34+), pericytes, and vascular smooth muscle cells in the lungs of female mice. In contrast, the number of cells involved in the angiogenesis decreased in the lungs of male animals. PegGLP-1 had a positive effect on lipids and area under the curve (AUC), obesity, and prevented the development of pulmonary emphysema. The severity of these effects was stronger in males than in females. Furthermore, PegGLP-1 stimulated regeneration of pulmonary endothelium. At the same time, PegGLP-1 administration caused a mobilization of EPC (CD45−CD31+CD34+) into the bloodstream in females and migration of precursors of angiogenesis and vascular smooth muscle cells to the lungs in male animals. Gender differences in stimulatory action of pegGLP-1 on CD31+ endothelial lung cells in vitro were not observed. Based on these findings, we postulated that the cellular mechanism of in vivo regeneration of lung epithelium was at least partly gender-specific. Thus, we concluded that a pegGLP-1-based treatment regime for metabolic disorder and COPD should be further developed primarily for male patients