3,449 research outputs found
Sub-2 cm/s passivation of silicon surfaces by aprotic solutions
Minimizing recombination at semiconductor surfaces is required for the accurate determination of the bulk carrier lifetime. Proton donors, such as hydrofluoric acid and superacids, are well known to provide highly effective short-term surface passivation. We demonstrate here that aprotic solutions based on bis(trifluoromethanesulfonyl)methane (TFSM) in hexane or pentane can also result in excellent passivation of (100)-orientation silicon surfaces. We show that the optimized TFSM-pentane passivation scheme can measure effective lifetimes up to 20 ms, with a surface recombination velocity of 1.7 cm s1 at an excess carrier density of 1015 cm3 . Fitting injection-dependent lifetime curves requires chemical passivation and field effect passivation from a negatively charged layer with a charge density of 1010–1011 q cm2 . The slightly higher recombination velocity of 2.3 cm s1 measured with TFSM-hexane can be explained by a lower charge density in the passivating layer, suggesting that the steric hindrance associated with the solvent size could play a role in the passivation mechanism. Finally, phosphorus nuclear magnetic resonance experiments confirm that TFSM-based solutions have Lewis acidity without being superacids, which opens up opportunities for them to be used in materials systems sensitive to superacidic environments
Improved limits on photon velocity oscillations
The mixing of the photon with a hypothetical sterile paraphotonic state would
have consequences on the cosmological propagation of photons. The absence of
distortions in the optical spectrum of distant Type Ia supernov\ae allows to
extend by two orders of magnitude the previous limit on the Lorentz-violating
parameter associated to the photon-paraphoton transition, extracted
from the abscence of distortions in the spectrum of the cosmic microwave
background. The new limit is consistent with the interpretation of the dimming
of distant Type Ia supernov\ae as a consequence of a nonzero cosmological
constant. Observations of gamma-rays from active galactic nuclei allow to
further extend the limit on by ten orders of magnitude.Comment: 10 pages, 4 Postscript figures, use epsfig, amssym
Turbulent Flows and Pollution Dispersion around Tall Buildings Using Adaptive Large Eddy Simulation (LES)
The motivation for this work stems from the increased number of high-rise buildings/skyscrapers all over the world, and in London, UK, and hence the necessity to see their effect on the local environment. We concentrate on the mean velocities, Reynolds stresses, turbulent kinetic energies (TKEs) and tracer concentrations. We look at their variations with height at two main locations within the building area, and downstream the buildings. The pollution source is placed at the top of the central building, representing an emission from a Combined Heat and Power (CHP) plant. We see how a tall building may have a positive effect at the lower levels, but a negative one at the higher levels in terms of pollution levels. Mean velocities at the higher levels (over 60 m in real life) are reduced at both locations (within the building area and downstream it), whilst Reynolds stresses and TKEs increase. However, despite the observed enhanced turbulence at the higher levels, mean concentrations increase, indicating that the mean flow has a greater influence on the dispersion. At the lower levels (Z < 60 m), the presence of a tall building enhanced dispersion (hence lower concentrations) for many of the configurations
Challenges in the management of juvenile idiopathic arthritis with etanercept
Biologic agents have been designed with the help of immunological studies to target particular areas of the immune system which are thought to play a role in the pathogenesis of disease. Etanercept is a soluble anti-tumor necrosis factor alpha (TNF-α) agent licensed for the treatment of active poly-articular juvenile idiopathic arthritis (JIA) in children aged 4 to 17 years who have failed to respond to methotrexate alone, or who have been intolerant of methotrexate. The safety and efficacy of etanercept in this patient group has been established by one randomized controlled trial and several longitudinal studies. This, together with the fact that until recently etanercept was the only anti-TNF licensed in JIA, has made it the most common first choice biologic for many clinicians. However, there are still many unanswered questions about etanercept, including its efficacy and safety in different subtypes of JIA, in children under 4 years of age and in those with uveitis. There are still concerns about the long term safety of TNF antagonists in the pediatric age group and unanswered questions about increased risks of malignancy and infection. Although adult studies are useful to improve understanding of these risks, they are not a substitute for good quality pediatric research and follow-up studies. Adult trials often include greater numbers of patients. However, they evaluate a different population and drug behavior may vary in children due to differences in metabolism, growth and impact on a developing immune system. In addition, rheumatoid arthritis is a different disease than JIA. Clinicians need to carefully weigh up the risk benefit ratio of anti-TNF use in children with JIA and push for robust clinical trials to address the questions that remain unanswered. This article summarizes the evidence available for use of etanercept in children with JIA and highlights aspects of treatment in need of further research
Prevention of Endotoxaemia in Obstructive Jaundice — a Comparative Study of Bile Salts
Systemic endotoxaemia is associated with postoperative renal dysfunction in obstructive jaundice, and
can be prevented by the pre-operative administration of certain bile salts. In order to find the most
effective bile salt for use in this condition, a comparison of the anti-endotoxic activities of different bile
salts was performed. Bile salts were incubated in vitro with endotoxin and the resultant endotoxin level
was measured with a quantitative limulus assay. The in vivo effects of different oral bile salts on the
intestinal absorption of radiolabelled endotoxin from rats with obstructive jaundice were compared. The
in vitro and in vivo anti-endotoxic activities of bile salts related to their known detergent activities.
Deoxycholic acid and its conjugates were the most effective and should be the bile salts of choice for
further clinical evaluation in obstructive jaundice in man
Active pixel sensor array with multiresolution readout
An imaging device formed as a monolithic complementary metal oxide semiconductor integrated circuit in an industry standard complementary metal oxide semiconductor process, the integrated circuit including a focal plane array of pixel cells, each one of the cells including a photogate overlying the substrate for accumulating photo-generated charge in an underlying portion of the substrate and a charge coupled device section formed on the substrate adjacent the photogate having a sensing node and at least one charge coupled device stage for transferring charge from the underlying portion of the substrate to the sensing node. There is also a readout circuit, part of which can be disposed at the bottom of each column of cells and be common to all the cells in the column. The imaging device can also include an electronic shutter formed on the substrate adjacent the photogate, and/or a storage section to allow for simultaneous integration. In addition, the imaging device can include a multiresolution imaging circuit to provide images of varying resolution. The multiresolution circuit could also be employed in an array where the photosensitive portion of each pixel cell is a photodiode. This latter embodiment could further be modified to facilitate low light imaging
The present rate of Supernovae
We present and discuss the most recent determination of the rate of
Supernovae in the local Universe. A comparison with other results shows a
general agreement on the gross values but still significant differences on the
values of the rates of various SN rates in different kinds of galaxies. The
rate of SNe, used as a probe of Star Formation, confirms the young progenitor
scenario for SNII+Ib/c. The increasing diversity of SNe reflects also in the SN
yields which may affect the chemical evolution of the Galaxy but, because of
the limited statistics, we cannot estimate the contributions of the new
subtypes yet. It is also expected that in a few years observational
determinations of the SN rates at various look-back times will be available.Comment: 9 pages, Latex, 1 figure, To appear in the proceedings of the
conference "The Chemical Evolution of The Milky Way: Stars versus Clusters",
eds. F. Matteucci and F. Giovannelli, Vulcano, Italy, September 20-24 199
Self-consistent modelling of hot plasmas within non-extensive Tsallis' thermostatistics
A study of the effects of non-extensivity on the modelling of atomic physics
in hot dense plasmas is proposed within Tsallis' statistics. The electronic
structure of the plasma is calculated through an average-atom model based on
the minimization of the non-extensive free energy.Comment: submitted to "Eur. Phys. J. D
Enhancing CFD-LES air pollution prediction accuracy using data assimilation
It is recognised worldwide that air pollution is the cause of premature deaths daily, thus necessitating the development of more reliable and accurate numerical tools. The present study implements a three dimensional Variational (3DVar) data assimilation (DA) approach to reduce the discrepancy between predicted pollution concentrations based on Computational Fluid Dynamics (CFD) with the ones measured in a wind tunnel experiment. The methodology is implemented on a wind tunnel test case which represents a localised neighbourhood environment. The improved accuracy of the CFD simulation using DA is discussed in terms of absolute error, mean squared error and scatter plots for the pollution concentration. It is shown that the difference between CFD results and wind tunnel data, computed by the mean squared error, can be reduced by up to three order of magnitudes when using DA. This reduction in error is preserved in the CFD results and its benefit can be seen through several time steps after re-running the CFD simulation. Subsequently an optimal sensors positioning is proposed. There is a trade-off between the accuracy and the number of sensors. It was found that the accuracy was improved when placing/considering the sensors which were near the pollution source or in regions where pollution concentrations were high. This demonstrated that only 14% of the wind tunnel data was needed, reducing the mean squared error by one order of magnitude
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