121 research outputs found
Data Imbalance, Uncertainty Quantification, and Generalization via Transfer Learning in Data-driven Parameterizations: Lessons from the Emulation of Gravity Wave Momentum Transport in WACCM
Neural networks (NNs) are increasingly used for data-driven subgrid-scale
parameterization in weather and climate models. While NNs are powerful tools
for learning complex nonlinear relationships from data, there are several
challenges in using them for parameterizations. Three of these challenges are
1) data imbalance related to learning rare (often large-amplitude) samples; 2)
uncertainty quantification (UQ) of the predictions to provide an accuracy
indicator; and 3) generalization to other climates, e.g., those with higher
radiative forcing. Here, we examine the performance of methods for addressing
these challenges using NN-based emulators of the Whole Atmosphere Community
Climate Model (WACCM) physics-based gravity wave (GW) parameterizations as the
test case. WACCM has complex, state-of-the-art parameterizations for
orography-, convection- and frontal-driven GWs. Convection- and
orography-driven GWs have significant data imbalance due to the absence of
convection or orography in many grid points. We address data imbalance using
resampling and/or weighted loss functions, enabling the successful emulation of
parameterizations for all three sources. We demonstrate that three UQ methods
(Bayesian NNs, variational auto-encoders, and dropouts) provide ensemble
spreads that correspond to accuracy during testing, offering criteria on when a
NN gives inaccurate predictions. Finally, we show that the accuracy of these
NNs decreases for a warmer climate (4XCO2). However, the generalization
accuracy is significantly improved by applying transfer learning, e.g.,
re-training only one layer using ~1% new data from the warmer climate. The
findings of this study offer insights for developing reliable and generalizable
data-driven parameterizations for various processes, including (but not
limited) to GWs
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Data Imbalance, Uncertainty Quantification, and Transfer Learning in Data-Driven Parameterizations: Lessons From the Emulation of Gravity Wave Momentum Transport in WACCM
Neural networks (NNs) are increasingly used for data-driven subgrid-scale parameterizations in weather and climate models. While NNs are powerful tools for learning complex non-linear relationships from data, there are several challenges in using them for parameterizations. Three of these challenges are (a) data imbalance related to learning rare, often large-amplitude, samples; (b) uncertainty quantification (UQ) of the predictions to provide an accuracy indicator; and (c) generalization to other climates, for example, those with different radiative forcings. Here, we examine the performance of methods for addressing these challenges using NN-based emulators of the Whole Atmosphere Community Climate Model (WACCM) physics-based gravity wave (GW) parameterizations as a test case. WACCM has complex, state-of-the-art parameterizations for orography-, convection-, and front-driven GWs. Convection- and orography-driven GWs have significant data imbalance due to the absence of convection or orography in most grid points. We address data imbalance using resampling and/or weighted loss functions, enabling the successful emulation of parameterizations for all three sources. We demonstrate that three UQ methods (Bayesian NNs, variational auto-encoders, and dropouts) provide ensemble spreads that correspond to accuracy during testing, offering criteria for identifying when an NN gives inaccurate predictions. Finally, we show that the accuracy of these NNs decreases for a warmer climate (4 × CO2). However, their performance is significantly improved by applying transfer learning, for example, re-training only one layer using ∼1% new data from the warmer climate. The findings of this study offer insights for developing reliable and generalizable data-driven parameterizations for various processes, including (but not limited to) GWs
Molecular dynamics simulations of oscillatory Couette flows with slip boundary conditions
The effect of interfacial slip on steady-state and time-periodic flows of
monatomic liquids is investigated using non-equilibrium molecular dynamics
simulations. The fluid phase is confined between atomically smooth rigid walls,
and the fluid flows are induced by moving one of the walls. In steady shear
flows, the slip length increases almost linearly with shear rate. We found that
the velocity profiles in oscillatory flows are well described by the Stokes
flow solution with the slip length that depends on the local shear rate.
Interestingly, the rate dependence of the slip length obtained in steady shear
flows is recovered when the slip length in oscillatory flows is plotted as a
function of the local shear rate magnitude. For both types of flows, the
friction coefficient at the liquid-solid interface correlates well with the
structure of the first fluid layer near the solid wall.Comment: 31 pages, 11 figure
Energy-efficient vertical handover parameters, classification and solutions over wireless heterogeneous networks: a comprehensive survey
In the last few decades, the popularity of wireless networks has been growing dramatically for both home and business networking. Nowadays, smart mobile devices equipped with various wireless networking interfaces are used to access the Internet, communicate, socialize and handle short or long-term businesses. As these devices rely on their limited batteries, energy-efficiency has become one of the major issues in both academia and industry. Due to terminal mobility, the variety of radio access technologies and the necessity of connecting to the Internet anytime and anywhere, energy-efficient handover process within the wireless heterogeneous networks has sparked remarkable attention in recent years. In this context, this paper first addresses the impact of specific information (local, network-assisted, QoS-related, user preferences, etc.) received remotely or locally on the energy efficiency as well as the impact of vertical handover phases, and methods. It presents energy-centric state-of-the-art vertical handover approaches and their impact on energy efficiency. The paper also discusses the recommendations on possible energy gains at different stages of the vertical handover process
H3.3(K27M) Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas
Gain-of-function mutations in histone 3 (H3) variants are found in a substantial proportion of pediatric high-grade gliomas (pHGG), often in association with TP53 loss and platelet-derived growth factor receptor alpha (PDGFRA) amplification. Here, we describe a somatic mouse model wherein H3.3K27M and Trp53 loss alone are sufficient for neoplastic transformation if introduced in utero. H3.3K27M-driven lesions are clonal, H3K27me3 depleted, Olig2 positive, highly proliferative, and diffusely spreading, thus recapitulating hallmark molecular and histopathological features of pHGG. Addition of wild-type PDGFRA decreases latency and increases tumor invasion, while ATRX knockdown is associated with more circumscribed tumors. H3.3K27M-tumor cells serially engraft in recipient mice, and preliminary drug screening reveals mutation-specific vulnerabilities. Overall, we provide a faithful H3.3K27M-pHGG model which enables insights into oncohistone pathogenesis and investigation of future therapies
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