Do managed clinical networks improve quality of diabetes care? : Evidence from a retrospective mixed methods evaluation

Peer reviewedPostprin

Design and development of a peristaltic pump for constant flow applications

In wide-ranging areas, including hydraulics, biomedical, automotive, and aerospace, there is often a need to move a fluid with a constant flow rate. This is difficult to achieve with any type of pump and usually other elements are inserted to regularize the output. This study focused on the peristaltic pump because there are few studies on it and it has some interesting features, such as extreme simplicity, a small number of components, and the extreme compactness of the whole system. The first part of this study is focused on analyzing the classical geometry of the peristaltic pump to understand the origin of the discontinuity in the flow rate; the second part proposes a new geometry that mitigates the flow irregularity by more than 200%. In this way, it is possible to use it in all the sectors where a constant flow rate is required but where insulation between the fluid and the machine is required. Together with the flow study, an analysis of how the main geometric parameters affect the operation of the pump is provided, complete with explanatory graphs and tables. A prototype made through additive manufacturing technologies is also proposed

Mobile health for cancer in low to middle income countries: priorities for research and development.

The is the accepted manuscript of an article published in the European Journal of Cancer Care (Holeman, I., Evans, J., Kane, D., Grant, L., Pagliari, C. and Weller, D. (2014), Mobile health for cancer in low to middle income countries: priorities for research and development. European Journal of Cancer Care, 23: 750–756. doi: 10.1111/ecc.12250)Many current global health opportunities have less to do with new biomedical knowledge than with the coordination and delivery of care. While basic research remains vital, the growing cancer epidemic in countries of low and middle income warrants urgent action - focusing on both research and service delivery innovation. Mobile technology can reduce costs, improve access to health services, and strengthen health systems to meet the interrelated challenges of cancer and other noncommunicable diseases. Experience has shown that even very poor and remote communities that only have basic primary health care can benefit from mobile health (or 'mHealth') interventions. We argue that cancer researchers and practitioners have an opportunity to leverage mHealth technologies that have successfully targeted other health conditions, rather than reinventing these tools. We call for particular attention to human centred design approaches for adapting existing technologies to suit distinctive aspects of cancer care and to align delivery with local context - and we make a number of recommendations for integrating mHealth delivery research with the work of designers, engineers and implementers in large-scale delivery programmes

The Immune Response to Tumors as a Tool toward Immunotherapy

Until recently cancer medical therapy was limited to chemotherapy that could not differentiate cancer cells from normal cells. More recently with the remarkable mushroom of immunology, newer tools became available, resulting in the novel possibility to attack cancer with the specificity of the immune system. Herein we will review some of the recent achievement of immunotherapy in such aggressive cancers as melanoma, prostatic cancer, colorectal carcinoma, and hematologic malignancies. Immunotherapy of tumors has developed several techniques: immune cell transfer, vaccines, immunobiological molecules such as monoclonal antibodies that improve the immune responses to tumors. This can be achieved by blocking pathways limiting the immune response, such as CTLA-4 or Tregs. Immunotherapy may also use cytokines especially proinflammatory cytokines to enhance the activity of cytotoxic T cells (CTLs) derived from tumor infiltrating lymphocytes (TILs). The role of newly discovered cytokines remains to be investigated. Alternatively, an other mechanism consists in enhancing the expression of TAAs on tumor cells. Finally, monoclonal antibodies may be used to target oncogenes

Fracture energy of sustainable geopolymer composites with and without the addition of slaughterhouse by-products as fibre-reinforcement: An experimental investigation

This work focuses on the development and on the mechanical characterization of geopolymer composites to be used as sustainable plasters or mortars. The starting point of the work is the synthesis of a geopolymer binder, which is subsequently used for the production of two different mortars: the first one is obtained by simply adding fine aggregates (control mortar), while in the second case, also slaughterhouse wastes (SHW) are included in the admixture. Nowadays, slaughtering industry produces a large amount of biological wastes, that are usually discarded via incineration or landfills. Among SHW, horns and hooves, which are rich in keratin, can be potentially used as additives in the manufacturing process of mortars, both in the form of fibre-reinforcement, as well as fine aggregates and fillers. In the second mortar considered in this work, 2% of SHW fibres and 2% of SHW filler are added in the admixture. The mechanical properties of the three products are experimentally investigated and compared to each other. Apart for compressive strength, close attention is paid to the flexural behaviour and to the determination of fracture energy. To evaluate the effect of SHW addition on crack propagation and width, digital image correlation technique is also adopted