Tracking data from nine free-roaming Cheetahs (Acinonyx jubatus) collared in the Thabazimbi area, Limpopo Province, South Africa

BACKGROUND : In partnership with the University of Pretoria, the Endangered Wildlife Trust's Carnivore Conservation Programme collared six male and three female free-roaming Cheetahs (Acinonyx jubatus) in the Thabazimbi area in Limpopo Province, South Africa. This study was undertaken to determine the spatial ecology of free-roaming Cheetahs that occur outside of formal protected areas on private ranchland, where they frequently come into conflict with, and are sometimes killed by, private landowners. The data were collected between September 2003 and November 2008, resulting in a total of 3165 location points (65 points from VHF collars and 3100 from GPS collars) for nine individual Cheetahs. NEW INFORMATION : This dataset provides distribution information about this Vulnerable species occurring outside of protected areas within South Africa. The dataset has been published to the Global Biodiversity Information Facility (www.GBIF.org) and provides the largest dataset on Cheetahs thus far, and, although it is spatially limited to a relatively small region on the African continent, it is the first study of its kind within South Africa. Also of significance is that the fate of 6 of the 9 collared Cheetahs is known, all except one of which died of anthropogenic causes.https://bdj.pensoft.netam2017Centre for Wildlife Managemen

Tracking data from nine free-roaming Cheetahs (Acinonyx jubatus) collared in the Thabazimbi area, Limpopo Province, South Africa

BACKGROUND : In partnership with the University of Pretoria, the Endangered Wildlife Trust's Carnivore Conservation Programme collared six male and three female free-roaming Cheetahs (Acinonyx jubatus) in the Thabazimbi area in Limpopo Province, South Africa. This study was undertaken to determine the spatial ecology of free-roaming Cheetahs that occur outside of formal protected areas on private ranchland, where they frequently come into conflict with, and are sometimes killed by, private landowners. The data were collected between September 2003 and November 2008, resulting in a total of 3165 location points (65 points from VHF collars and 3100 from GPS collars) for nine individual Cheetahs. NEW INFORMATION : This dataset provides distribution information about this Vulnerable species occurring outside of protected areas within South Africa. The dataset has been published to the Global Biodiversity Information Facility (www.GBIF.org) and provides the largest dataset on Cheetahs thus far, and, although it is spatially limited to a relatively small region on the African continent, it is the first study of its kind within South Africa. Also of significance is that the fate of 6 of the 9 collared Cheetahs is known, all except one of which died of anthropogenic causes.https://bdj.pensoft.netam2017Centre for Wildlife Managemen

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Socio-economic factors influencing attitudes of landowners towards free-roaming cheetahs

The largest area of the South African cheetah (Acinonyx jubatus) distribution occurs outside formally protected areas, making cheetahs vulnerable to conflict-related killings. This conflict is assumed to be related to negative attitudes of landowners towards predators. Our study assessed the socio-economic factors influencing landowner attitudes towards cheetahs on private properties adjacent to the Kruger National Park (Kruger), South Africa. We used structured questionnaires to interview 199 landowners. Attitudes of landowners towards cheetahs were generally positive; 58% of landowners had attitude index scores between eight and 11. However, 11% had fairly negative or low scores (scores between –2 and 4). First language, land use and respondent knowledge of cheetahs were key drivers of attitude. English speaking landowners (49.8%) were more likely to display positive attitudes towards cheetahs than Afrikaans first-language speakers (46.8%). In addition, the likelihood of having a more positive attitude increased significantly as respondent knowledge of cheetahs increased. Attitudes were also influenced by land use, with wildlife ranchers or ecotourism ventures having a significantly higher probability of having more positive attitudes than livestock farmers. With the Kruger being a stronghold for cheetah conservation in Africa, and large carnivores being vulnerable to edge effects in protected areas, it is important to understand the factors driving conflict so that mitigation efforts can be targeted for maximum impact.http://www.sawma.co.zaam2018Centre for Wildlife Managemen

The African Crane Database (1978-2014): Records of three threatened crane species (Family: Gruidae) from southern and eastern Africa

The International Crane Foundation (ICF) / Endangered Wildlife Trust's (EWT) African Crane Conservation Programme has recorded 26 403 crane sightings in its database from 1978 to 2014. This sightings collection is currently ongoing and records are continuously added to the database by the EWT field staff, ICF/EWT Partnership staff, various partner organizations and private individuals. The dataset has two peak collection periods: 1994-1996 and 2008-2012. The dataset collection spans five African countries: Kenya, Rwanda, South Africa, Uganda and Zambia; 98% of the data were collected in South Africa. Georeferencing of the dataset was verified before publication of the data. The dataset contains data on three African crane species: Blue Crane Anthropoides paradiseus, Grey Crowned Crane Balearica regulorum and Wattled Crane Bugeranus carunculatus. The Blue and Wattled Cranes are classified by the IUCN Red List of Threatened Species as Vulnerable and the Grey Crowned Crane as Endangered. This is the single most comprehensive dataset published on African Crane species that adds new information about the distribution of these three threatened species. We hope this will further aid conservation authorities to monitor and protect these species. The dataset continues to grow and especially to expand in geographic coverage into new countries in Africa and new sites within countries. The dataset can be freely accessed through the Global Biodiversity Information Facility data portal

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19

International audienc

Genomic reconstruction of the SARS-CoV-2 epidemic in England

AbstractThe evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.</jats:p