Biochemical changes in the cerebrospinal fluid and blood during peritoneal dialysis for uraemic acidosis

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Bounds from Primordial Black Holes with a Near Critical Collapse Initial Mass Function

Recent numerical evidence suggests that a mass spectrum of primordial black holes (PBHs) is produced as a consequence of near critical gravitational collapse. Assuming that these holes formed from the initial density perturbations seeded by inflation, we calculate model independent upper bounds on the mass variance at the reheating temperature by requiring the mass density not exceed the critical density and the photon emission not exceed current diffuse gamma-ray measurements. We then translate these results into bounds on the spectral index n by utilizing the COBE data to normalize the mass variance at large scales, assuming a constant power law, then scaling this result to the reheating temperature. We find that our bounds on n differ substantially (\delta n > 0.05) from those calculated using initial mass functions derived under the assumption that the black hole mass is proportional to the horizon mass at the collapse epoch. We also find a change in the shape of the diffuse gamma-ray spectrum which results from the Hawking radiation. Finally, we study the impact of a nonzero cosmological constant and find that the bounds on n are strengthened considerably if the universe is indeed vacuum-energy dominated today.Comment: 24 pages, REVTeX, 5 figures; minor typos fixed, two refs added, version to be published in PR

Demonstration of the anthelmintic potency of marimastat in the Heligmosomoides polygyrus rodent model

In the course of a structure based drug discovery program the known anticancer candidate marimastat was uncovered as a potent inhibitor of an enzyme in nematode cuticle biogenesis. It was shown to kill Caenorhabditis elegans, and the sheep parasites Haemonchus contortus and Teladorsagia circumcinta via an entirely novel nematode-specific pathway, specifically by inhibiting cuticle-remodelling enzymes that the parasites require for the developmentally essential moulting process. This discovery prompted an investigation of the compound's effect on Heligmosomoides polygyrus parasites in a mouse model of helminth infection. Mice were administered the drug via oral gavage daily from day of infection for a period of 2 wk. A second group received the drug via intra-peritoneal implantation of an osmotic minipump for 4 wk. Control groups were administered identical volumes of water by oral gavage in both cases. Counts of H. polygyrus faecal egg and larval load showed that marimastat effected a consistent and significant reduction in egg laying, and a consistent but minor reduction in adult worm load when administered every day, starting on the first day of infection. However, the drug failed to have any significant effect on egg counts or worm burdens when administered to mice with established infections. Therefore, marimastat does not appear to show promise as an anthelmintic in gastrointestinal nematode infections, although other metalloproteases such as batimastat may prove more effective

Cooling of Neutron Stars with Strong Toroidal Magnetic Fields

We present models of temperature distribution in the crust of a neutron star in the presence of a strong toroidal component superposed to the poloidal component of the magnetic field. The presence of such a toroidal field hinders heat flow toward the surface in a large part of the crust. As a result, the neutron star surface presents two warm regions surrounded by extended cold regions and has a thermal luminosity much lower than in the case the magnetic field is purely poloidal. We apply these models to calculate the thermal evolution of such neutron stars and show that the lowered photon luminosity naturally extends their life-time as detectable thermal X-ray sources

Complementary approaches to understanding the plant circadian clock

Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far. Its many advantages as an experimental system facilitate the testing of computational predictions. We present a model of the Ostreococcus clock in the stochastic process algebra Bio-PEPA and exploit its mapping to different analysis techniques, such as ordinary differential equations, stochastic simulation algorithms and model-checking. The small number of molecules reported for this system tests the limits of the continuous approximation underlying differential equations. We investigate the difference between continuous-deterministic and discrete-stochastic approaches. Stochastic simulation and model-checking allow us to formulate new hypotheses on the system behaviour, such as the presence of self-sustained oscillations in single cells under constant light conditions. We investigate how to model the timing of dawn and dusk in the context of model-checking, which we use to compute how the probability distributions of key biochemical species change over time. These show that the relative variation in expression level is smallest at the time of peak expression, making peak time an optimal experimental phase marker. Building on these analyses, we use approaches from evolutionary systems biology to investigate how changes in the rate of mRNA degradation impacts the phase of a key protein likely to affect fitness. We explore how robust this circadian clock is towards such potential mutational changes in its underlying biochemistry. Our work shows that multiple approaches lead to a more complete understanding of the clock

Viability of primordial black holes as short period gamma-ray bursts

It has been proposed that the short period gamma-ray bursts, which occur at a rate of $\sim 10 {\rm yr^{-1}}$, may be evaporating primordial black holes (PBHs). Calculations of the present PBH evaporation rate have traditionally assumed that the PBH mass function varies as $M_{{\rm BH}}^{-5/2}$. This mass function only arises if the density perturbations from which the PBHs form have a scale invariant power spectrum. It is now known that for a scale invariant power spectrum, normalised to COBE on large scales, the PBH density is completely negligible, so that this mass function is cosmologically irrelevant. For non-scale-invariant power spectra, if all PBHs which form at given epoch have a fixed mass then the PBH mass function is sharply peaked around that mass, whilst if the PBH mass depends on the size of the density perturbation from which it forms, as is expected when critical phenomena are taken into account, then the PBH mass function will be far broader than $M_{{\rm BH}}^{-5/2}$. In this paper we calculate the present day PBH evaporation rate, using constraints from the diffuse gamma-ray background, for both of these mass functions. If the PBH mass function has significant finite width, as recent numerical simulations suggest, then it is not possible to produce a present day PBH evaporation rate comparable with the observed short period gamma-ray burst rate. This could also have implications for other attempts to detect evaporating PBHs.Comment: 5 pages, 2 figures, version to appear in Phys. Rev. D with additional reference

Miracles and complementarity in de Sitter space

In this paper we consider a scenario, consisting of a de Sitter phase followed by a phase described by a scale factor $a(t)\sim t^{q}$, where $1/3<q<1$, which can be viewed as an inflationary toy model. It is argued that this scenario naively could lead to an information paradox. We propose that the phenomenon of Poincar\'{e} recurrences plays a crucial role in the resolution of the paradox. We also comment on the relevance of these results to inflation and the CMBR.Comment: 13 page

Constraints on diffuse neutrino background from primordial black holes

We calculated the energy spectra and the fluxes of electron neutrino emitted in the process of evaporation of primordial black holes (PBHs) in the early universe. It was assumed that PBHs are formed by a blue power-law spectrum of primordial density fluctuations. We obtained the bounds on the spectral index of density fluctuations assuming validity of the standard picture of gravitational collapse and using the available data of several experiments with atmospheric and solar neutrinos. The comparison of our results with the previous constraints (which had been obtained using diffuse photon background data) shows that such bounds are quite sensitive to an assumed form of the initial PBH mass function.Comment: 18 pages,(with 7 figures

Bouncing pre-big bang on the brane

A regular bouncing universe is obtained in the context of a dilaton-gravity brane world scenario. The scale factor starts in a contracting inflationary phase both in the Einstein and in the string frame, it then undergoes a bounce (due to interaction with the bulk Weyl tensor), and subsequently enters into a decelerated expanding era. This graceful exit is obtained at low curvature and low coupling, and without violating the Null Energy Condition.Comment: 16 pages, 3 figures; final version to be published on PRD. General improvement of section II (better specification of the matter content on the brane and discussion about the late time behavior), main results unchanged; 2 references adde

Brans-Dicke Theory and primordial black holes in Early Matter-Dominated Era

We show that primordial black holes can be formed in the matter-dominated era with gravity described by the Brans-Dicke theory. Considering an early matter-dominated era between inflation and reheating, we found that the primordial black holes formed during that era evaporate at a quicker than those of early radiation-dominated era. Thus, in comparison with latter case, less number of primordial black holes could exist today. Again the constraints on primordial black hole formation tend towards the larger value than their radiation-dominated era counterparts indicating a significant enhancement in the formation of primordial black holes during the matter-dominaed era.Comment: 9 page