Circadian variation in gastric vagal afferent mechanosensitivity

Food intake is coordinated to cellular metabolism by clock gene expression with a master clock in the suprachiasmatic nucleus synchronized by light exposure. Gastric vagal afferents play a role in regulating food intake, but it is unknown whether they exhibit circadian variation in their mechanosensitivity. We aimed to determine whether gastric vagal afferents express clock genes and whether their response to mechanical stimuli oscillates throughout the light/dark cycle. Nodose ganglia were collected from 8-week-old female C57BL/6 mice every 3 h starting at lights off (1800 h) to quantify Bmal1, Per1, Per2, and Nr1d1 mRNA by qRT-PCR. Additionally in vitro single-fiber recordings of gastric vagal mechanoreceptors were taken at all time points. Per1, Per2, Bmal1, and Nr1d1 mRNA is expressed in the nodose ganglia and levels oscillated over a 24 h period. In mice fed ad libitum, gastric content was 3 times higher at 0000 h and 0300 h than 1200 h. The response of tension receptors to 3 g stretch was reduced by up to 70% at 2100 h, 0000 h, and 0300 h compared with 1200 h. Gastric mucosal receptor response to stroking with a 50 mg von Frey hair was 3 times greater at 1200 h and 1500 h than the response at 0000 h. Similar findings were obtained in mice fasted for 6 h or maintained in darkness for 3 d before study. Therefore, these changes do not result from food intake or the light/dark cycle. Thus, gastric vagal mechanoreceptors display circadian rhythm, which may act to control food intake differentially at different times of the day.Stephen J. Kentish, Claudine L. Frisby, David J. Kennaway, Gary A. Wittert, and Amanda J. Pag

The XMM-Newton spectral-fit database

The XMM-Newton spectral-fit database is an ongoing ESA funded project aimed to construct a catalogue of spectral-fitting results for all the sources within the XMM-Newton serendipitous source catalogue for which spectral data products have been pipeline-extracted (~ 120,000 X-ray source detections). The fundamental goal of this project is to provide the astronomical community with a tool to construct large and representative samples of X-ray sources by allowing source selection according to spectral properties.Comment: Conference proceedings of IAU Symposium 304: Multiwavelength AGN surveys and studie

A new solid-state logarithmic radiometer

Combination of temperature-compensated logarithmic amplifiers and p-i-n photodiodes operating in zero-bias mode provides lightweight radiometer for detecting spectral intensities encompassing more than three decades over a range of at least 300 to 800 nanometers at low power levels

XMM-Newton observations of the Seyfert 1 AGN H0557-385

We present XMM-Newton observations of the Seyfert 1 AGN H0557-385. We have conducted a study into the warm absorber present in this source, and using high-resolution RGS data we find that the absorption can be characterised by two phases: a phase with log ionisation parameter xi of 0.50 (where xi is in units of ergs cm/s) and a column of 0.2e21 cm^-2, and a phase with log xi of 1.62 and a column of 1.3e22 cm^-2. An iron K alpha line is detected. Neutral absorption is also present in the source, and we discuss possible origins for this. On the assumption that the ionised absorbers originate as an outflow from the inner edge of the torus, we use a new method for finding the volume filling factor. Both phases of H0557-385 have small volume filling factors (< 1%). We also derive the volume filling factors for a sample of 23 AGN using this assumption and for the absorbers with log xi > 0.7 we find reasonable agreement with the filling factors obtained through the alternative method of equating the momentum flow of the absorbers to the momentum loss of the radiation field. By comparing the filling factors obtained by the two methods, we infer that some absorbers with log xi < 0.7 occur at significantly larger distances from the nucleus than the inner edge of the torus.Comment: Accepted for publication in MNRA

A simultaneous XMM-Newton and BeppoSAX observation of the archetypal Broad Line Seyfert 1 galaxy NGC 5548

We report the spectral analysis of a long XMM-Newton observation of the well-studied, moderate luminosity Broad Line Seyfert 1 galaxy NGC 5548. The source was at an historically average brightness and we find the hard (3-10 keV) spectrum can be well fitted by a power law of photon index gamma ~ 1.75, together with reflection. The only feature in the hard X-ray spectrum is a narrow emission line near 6.4 keV, with an equivalent width of ~ 60 eV. The energy and strength of this line is consistent with fluorescence from `neutral' iron distant from the central continuum source. We find no evidence for a broad Fe K line, with an upper limit well below previous reports, suggesting the inner accretion disc is now absent or highly ionised. The addition of simultaneous BeppoSAX data allows the analysis to be extended to 200 keV, yielding important constraints on the total reflection. Extrapolation of the hard X-ray power law down to 0.3 keV shows a clear `soft excess' below ~ 0.7 keV. After due allowance for the effects of a complex warm absorber, measured with the XMM-Newton RGS, we find the soft excess is better described as a smooth upward curvature in the continuum flux below ~ 2 keV. The soft excess can be modelled either by Comptonised thermal emission or by enhanced reflection from the surface of a highly ionised disc.Comment: 9 pages, 11 figures, accepted by MNRAS; minor changes to text and figure

Fe K emission and absorption features in XMM-Newton spectra of Mkn 766 - evidence for reprocessing in flare ejecta

We report on the analysis of a long XMM-Newton EPIC observation in 2001 May of the Narrow Line Seyfert 1 galaxy Mkn 766. The 3-11 keV spectrum exhibits a moderately steep power law continuum, with a broad emission line at ~6.7 keV, probably blended with a narrow line at ~6.4 keV, and a broad absorption trough above ~8.7 keV. We identify both broad spectral features with reprocessing in He-like Fe. An earlier XMM-Newton observation of Mkn 766 in 2000 May, when the source was a factor ~2 fainter, shows a similar broad emission line, but with a slightly flatter power law and absorption at a lower energy. In neither observation do we find a requirement for the previously reported broad 'red wing' to the line and hence of reflection from the innermost accretion disc. More detailed examination of the longer XMM-Newton observation reveals evidence for rapid spectral variability in the Fe K band, apparently linked with the occurrence of X-ray 'flares'. A reduction in the emission line strength and increased high energy absorption during the X-ray flaring suggests that these transient effects are due to highly ionised ejecta associated with the flares. Simple scaling from the flare avalanche model proposed for the luminous QSO PDS 456 (Reeves etal. 2002) confirms the feasibility of coherent flaring being the cause of the strong peaks seen in the X-ray light curve of \mkn.Comment: 9 pages, 11 figures, submitted to MNRA

GEMINGA'S SOFT X-RAY EMISSION AND THE STRUCTURE OF ITS SURFACE

We present a model to explain the decrease in the amplitude of the pulse profile with increasing energy observed in Geminga's soft X-ray surface thermal emission. We assume the presence of plates surrounded by a surface with very distinct physical properties: these two regions emit spectra of very distinct shapes which present a crossover, the warm plates emitting a softer spectrum than the colder surrounding surface. The strongly pulsed emission from the plates dominates at low energy while the surroundings emission dominates at high energy, producing naturally a strong decrease in the pulsed fraction. In our illustrative example the plates are assumed to be magnetized while the rest of the surface is field free. This plate structure may be seen as a schematic representation of a continuous but very nonuniform distribution of the surface magnetic field or as a quasi realistic structure induced by past tectonic activity on Geminga.Comment: 10 pages, AASTeX latex, + 3 figures (compressed 7 uuencoded). Submitted to Ap. J. Let

Agnesi Weighting for the Measure Problem of Cosmology

The measure problem of cosmology is how to assign normalized probabilities to observations in a universe so large that it may have many observations occurring at many different spacetime locations. I have previously shown how the Boltzmann brain problem (that observations arising from thermal or quantum fluctuations may dominate over ordinary observations if the universe expands sufficiently and/or lasts long enough) may be ameliorated by volume averaging, but that still leaves problems if the universe lasts too long. Here a solution is proposed for that residual problem by a simple weighting factor 1/(1+t^2) to make the time integral convergent. The resulting Agnesi measure appears to avoid problems other measures may have with vacua of zero or negative cosmological constant.Comment: 26 pages, LaTeX; discussion is added of how Agnesi weighting appears better than other recent measure

Dielectric anomalies and spiral magnetic order in CoCr2O4

We have investigated the structural, magnetic, thermodynamic, and dielectric properties of polycrystalline CoCr$_2$O$_4$, an insulating spinel exhibiting both ferrimagnetic and spiral magnetic structures. Below $T_c$ = 94 K the sample develops long-range ferrimagnetic order, and we attribute a sharp phase transition at $T_N$ $\approx$ 25 K with the onset of long-range spiral magnetic order. Neutron measurements confirm that while the structure remains cubic at 80 K and at 11 K; there is complex magnetic ordering by 11 K. Density functional theory supports the view of a ferrimagnetic semiconductor with magnetic interactions consistent with non-collinear ordering. Capacitance measurements on CoCr$_2$O$_4$, show a sharp decrease in the dielectric constant at $T_N$, but also an anomaly showing thermal hysteresis falling between approximately $T$ = 50 K and $T$ = 57 K. We tentatively attribute the appearance of this higher temperature dielectric anomaly to the development of \textit{short-range} spiral magnetic order, and discuss these results in the context of utilizing dielectric spectroscopy to investigate non-collinear short-range magnetic structures.Comment: & Figure