DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF EPERISONE HYDROCHLORIDE IN BULK DRUG

Objective: A new, economical, precise and accurate stability indicating HPTLC method was developed and validated for the determination of Eperisone hydrochloride in bulk drug.Methods: Sample and standard solutions of Eperisone hydrochloride was applied on precoated silica gel G 60 F254 HPTLC plate and the plate was developed using Toluene: Chloroform: Ethanol (4:4:1v/v/v) as mobile phase. The detection was performed at 266 nmResults: The calibration curve was found to be linear between 100 to 700 ng/spot for Eperisone hydrochloride with correlation coefficients 0.999. The Rf value for Eperisone hydrochloride was found to be 0.26±0.03. The LOD and LOQ were found to be 100 ng/spot and 300 ng/spot for Eperisone hydrochloride. The selected drug was subjected to acid, alkali and oxidative degradation and study revealed, Eperisone hydrochloride is well resolved from pure form with significant differences in their Rf this method can be successfully employed for quantitative analysis of Eperisone hydrochloride in bulk drug.Conclusion: The proposed method has been validated as per ICH Q2 (R1) guidelines. This method can be used for routine quality control analysis of Eperisone hydrochloride in bulk drug.Â

GUI Testing On Android Application

As Android phones is been used widely for different types of applications. But the people who stay in rural areas do not afford the high range mobile phones which support all the functionality. In this application system implementing Marathi/Hindi support for all versions (especially for older version). In this application system have provided with Hindi/Marathi keypad for messenger as well as dialler instead of 1, 2 and 3, a, b, c. It will reflect in Marathi/Hindi. As we know that in regular android phones we cannot make a call on just looking to a photo of dialler, but in this application system can have a look on photo to whom the number belong and can make a call on a single click without having the knowledge of the user phone number. System developed a new application called as N-indicator that is Nashik indicator, it will contain all the information of train routes, bus routes with it is fare, auto rates with it fare, visitor’s place, hotels with its fare. DOI: 10.17762/ijritcc2321-8169.15011

FORMULATION AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF LORNOXICAM

Lornoxicam is a NSAID having oxicam class mainly prescribed in the treatment of osteoarthritis and rheumatoid arthritis. NSAID have the potential to relieve the pain and inflammation without the immunosuppressive and metabolic side effects associated with corticosteroids. Generally the classification of NSAID is applied to drugs that inhibit one or more steps in the metabolism of Arachidonic Acid (AA). In general, NSAID do not inhibit lipoxygenase formation or the formation of other inflammatory mediators. Due to its more biological half-life i.e. 3-5 hrs. in India, the dosage form is available in 8-16 mg, it can be increased upto 24 mg/day if necessary. The main objectives of present investigation are to confirm the drug by various analytical techniques, to study the drug excipients compatibility, to avoid the dose as well as the frequency of the dosage form and to perform the stability. The tablet can be developed with the combination of HPMC K 100M and Ethyl Cellulose as a matrix former. Lornoxicam is NSAID that has numerous functions in the body. It can be absorbed rapidly and completely from gastrointestinal track after the oral administration. Absolute bioavailability of Lornoxicam is 90-100%. No first pass effect is observed. It is found in the plasma in the unchanged form and as its hydroxylated metabolite. The hydroxylated metabolite exhibits no pharmacological activity. CYP2C3 has been shown to be the primary enzyme responsible for the biotransformation of Lornoxicam. Approximately 2/3 part of Lornoxicam is eliminated via the liver and 1/3 via the kidneys as inactive substance. Lornoxicam inhibits the production of prostaglandins by inhibiting the action of cyclooxygenase, which regulates the conversion of Arachidonic Acid to Prostaglandins. Lornoxicam mainly prescribed in the treatment of osteoarthritis and rheumatoid arthritis, and also in the management of ankylosing spondylitis, acute sciatica and low back pain.Keywords: Lornoxicam, Sustained release, matrix

Hydroformylation of olefins using dispersed molecular catalysts on solid supports

A new method for heterogenization of metal complex catalysts by precipitation of its water-soluble analogue as a Gr.2 metals (Ca, Sr or Ba) salt on porous supports has been proposed. This technique yields a highly dispersed catalyst having a significantly higher activity (TOF) for hydroformylation of olefins compared to other known heterogenized catalysts. The catalyst can be recycled with ease

A Comprehensive Review Of Drug-Device Combination

<p>The trend of combining drugs and devices has brought about advancements in medical product development, regulatory approval, and business involvement. These combination products are designed with modern links between key technologies and complementary elements, while still maintaining their fundamental purpose. To better understand the benefits and drawbacks of these combination medications, we will look at case studies of drug-device stents and transdermal patches. It seems that this generation of combination products has created a new, high-value area, as evidenced by advancements in product control and the realization that the competitive advantage lies in the sophistication of the mix. Recent studies show that combining technology, medicine, and biologics creates a developing opportunity. According to our analysis, a new type of combination product's first product includes both the regulator and the sponsor. If this first product is granted a license, it can greatly reduce uncertainty around the entire class of combination medications, establishing a leading regulatory center. The sponsor of a new type of combination product is crucial in reducing uncertainty by helping decision-makers understand the fundamental objective of the combination product.</p&gt

Catalytic Enantio­selective Hetero-dimerization of Acrylates and 1,3-Dienes

1,3-Dienes are ubiquitous and easily synthesized starting materials for organic synthesis, and alkyl acrylates are among the most abundant and cheapest feedstock carbon sources. A practical, highly enantio­selective union of these two readily available precursors giving valuable, enantio-pure skipped 1,4-diene esters (with two configurationally defined double bonds) is reported. The process uses commercially available cobalt salts and chiral ligands. As illustrated by the use of 20 different substrates, including 17 prochiral 1,3-dienes and 3 acrylates, this hetero-dimerization reaction is tolerant of a number of common organic functional groups (e.g., aromatic substituents, halides, isolated mono- and di-substituted double bonds, esters, silyl ethers, and silyl enol ethers). The novel results including ligand, counterion, and solvent effects uncovered during the course of these investigations show a unique role of a possible cationic Co­(I) intermediate in these reactions. The rational evolution of a mechanism-based strategy that led to the eventual successful outcome and the attendant support studies may have further implications for the expanding use of low-valent group 9 metal complexes in organic synthesis