Cholinergic imaging in dementia spectrum disorders

The multifaceted nature of the pathology of dementia spectrum disorders has complicated their management and the development of effective treatments. This is despite the fact that they are far from uncommon, with Alzheimer’s disease (AD) alone affecting 35 million people worldwide. The cholinergic system has been found to be crucially involved in cognitive function, with cholinergic dysfunction playing a pivotal role in the pathophysiology of dementia. The use of molecular imaging such as SPECT and PET for tagging targets within the cholinergic system has shown promise for elucidating key aspects of underlying pathology in dementia spectrum disorders, including AD or parkinsonian dementias. SPECT and PET studies using selective radioligands for cholinergic markers, such as [(11)C]MP4A and [(11)C]PMP PET for acetylcholinesterase (AChE), [(123)I]5IA SPECT for the α(4)β(2) nicotinic acetylcholine receptor and [(123)I]IBVM SPECT for the vesicular acetylcholine transporter, have been developed in an attempt to clarify those aspects of the diseases that remain unclear. This has led to a variety of findings, such as cortical AChE being significantly reduced in Parkinson’s disease (PD), PD with dementia (PDD) and AD, as well as correlating with certain aspects of cognitive function such as attention and working memory. Thalamic AChE is significantly reduced in progressive supranuclear palsy (PSP) and multiple system atrophy, whilst it is not affected in PD. Some of these findings have brought about suggestions for the improvement of clinical practice, such as the use of a thalamic/cortical AChE ratio to differentiate between PD and PSP, two diseases that could overlap in terms of initial clinical presentation. Here, we review the findings from molecular imaging studies that have investigated the role of the cholinergic system in dementia spectrum disorders

Asymmetric Twisting of Coronal Loops

The bright solar corona entirely consists of closed magnetic loops rooted in the photosphere. Photospheric motions are important drivers of magnetic stressing, which eventually leads to energy release into heat. These motions are chaotic and obviously different from one footpoint to the other, and in fact, there is strong evidence that loops are finely stranded. One may also expect strong transient variations along the field lines, but at a glance, coronal loops ever appear more or less uniformly bright from one footpoint to the other. We aim to understand how much coronal loops can preserve their own symmetry against asymmetric boundary motions that are expected to occur at loop footpoints. We investigate this issue by time-dependent 2.5D MHD modelling of a coronal loop, including its rooting and beta-variation in the photosphere. We assume that the magnetic flux tube is stressed by footpoint rotation but also that the rotation has a different pattern from one footpoint to the other. In this way, we force strong asymmetries because we expect independent evolution along different magnetic strands. We found that until the Alfven crossing-travel time relative to the entire loop length is much lower than the twisting period, the loop's evolution depends only on the relative velocity between the boundaries, and the symmetry is efficiently preserved. We conclude that the very high Alfven velocities that characterise the coronal environment can explain why coronal loops can maintain a very high degree of symmetry even when they are subjected to asymmetric photospheric motions for a long time

lensingGW: a Python package for lensing of gravitational waves

Advanced LIGO and Advanced Virgo could observe the first lensed gravitational waves in the coming years, while the future Einstein Telescope could observe hundreds of lensed events. Ground-based gravitational-wave detectors can resolve arrival time differences of the order of the inverse of the observed frequencies. As LIGO/Virgo frequency band spans from a few $\rm Hz$ to a few $\rm kHz$, the typical time resolution of current interferometers is of the order of milliseconds. When microlenses are embedded in galaxies or galaxy clusters, lensing can become more prominent and result in observable time delays at LIGO/Virgo frequencies. Therefore, gravitational waves could offer an exciting alternative probe of microlensing. However, currently, only a few lensing configurations have been worked out in the context of gravitational-wave lensing. In this paper, we present lensingGW, a Python package designed to handle both strong and microlensing of compact binaries and the related gravitational-wave signals. This synergy paves the way for systematic parameter space investigations and the detection of arbitrary lens configurations and compact sources. We demonstrate the working mechanism of lensingGW and its use to study microlenses embedded in galaxies.Comment: 11 pages, 10 figure

Setting up of an experimental site for the continuous monitoring of water discharge, suspended sediment transport and groundwater levels in a mediterranean basin. Results of one year of activity

The study of suspended sediment transport requires continuous measurement of water discharge to better understand the sediment dynamics. Furthermore, a groundwater monitoring network can support the stream discharge measures, as it reveals how the interactions between surface water and groundwater may affect runoff and consequently sediment transport during flood events. An experimental site for the continuous monitoring of water discharge, suspended sediment transport and groundwater levels was set up in the Carapellotto basin (27.17 km2), which is located in Apulia, Southern Italy. Seven flood events that occurred in the operation timespan were covered with a full record of both water discharge and sediment concentration. Some monitoring problems, largely due to the clogging of the float by mud, suggested to improve the experimental set up. The results show high values of suspended sediments concentration which indicate the sub-basin’s key role in the sediment delivery to the whole river system, while counter-clockwise hysteresis loops are the most frequent due to the basin characteristics. The effects of the interaction between surface water and groundwater are related not only to the flood magnitude but also to the hydrogeological features in the hyporheic zone

Adaptive Algorithms for Batteryless LoRa-Based Sensors

Ambient energy-powered sensors are becoming increasingly crucial for the sustainability of the Internet-of-Things (IoT). In particular, batteryless sensors are a cost-effective solution that require no battery maintenance, last longer and have greater weatherproofing properties due to the lack of a battery access panel. In this work, we study adaptive transmission algorithms to improve the performance of batteryless IoT sensors based on the LoRa protocol. First, we characterize the device power consumption during sensor measurement and/or transmission events. Then, we consider different scenarios and dynamically tune the most critical network parameters, such as inter-packet transmission time, data redundancy and packet size, to optimize the operation of the device. We design appropriate capacity-based storage, considering a renewable energy source (e.g., photovoltaic panel), and we analyze the probability of energy failures by exploiting both theoretical models and real energy traces. The results can be used as feedback to re-design the device to have an appropriate amount energy storage and meet certain reliability constraints. Finally, a cost analysis is also provided for the energy characteristics of our system, taking into account the dimensioning of both the capacitor and solar panel

Coordinated X-ray and Optical observations of Star-Planet Interaction in HD 17156

The large number of close-in Jupiter-size exoplanets prompts the question whether star-planet interaction (SPI) effects can be detected. We focused our attention on the system HD 17156, having a Jupiter-mass planet in a very eccentric orbit. Here we present results of the XMM-Newton observations and of a five months coordinated optical campaign with the HARPS-N spectrograph. We observed HD 17156 with XMM-Newton when the planet was approaching the apoastron and then at the following periastron passage, quasi simultaneously with HARPS-N. We obtained a clear ($\approx 5.5\sigma$) X-ray detection only at the periastron visit, accompanied by a significant increase of the $R'_{\rm HK}$ chromospheric index. We discuss two possible scenarios for the activity enhancement: magnetic reconnection and flaring or accretion onto the star of material tidally stripped from the planet. In any case, this is possibly the first evidence of a magnetic SPI effect caught in action

Alpha-particle clustering in excited expanding self-conjugate nuclei

The fragmentation of quasi-projectiles from the nuclear reaction 40Ca + 12C at 25 MeV/nucleon was used to produce alpha-emission sources. From a careful selection of these sources provided by a complete detection and from comparisons with models of sequential and simultaneous decays, strong indications in favour of $\alpha$-particle clustering in excited 16O, 20Ne and 24}Mg are reported.Comment: 8 pages, 4 figures, 12th International Conference on Nucleus-Nucleus collisions (NN2015), 21-26 June 2015, Catania, Ital