Screening tests, information, and the health-education gradient

The association between health outcomes and education - the health-education gradient - is widely documented but little is known about its source. Using microeconomic data on a sample of individuals aged 50+ in eight European countries, we find that education and cognitive skills (such as verbal fluency) are associated with a greater propensity for standard screening tests (mammography and colonoscopy). In order to study the role of information on the decision to screen, we test whether the health-education gradient varies with the quality of the information provided by the health care system, as proxied by the quality of the General Practitioner. Using an Instrumental Variable approach to control for the potential endogeneity of the GP quality score, we find evidence of a strong and significant complementarity between education and quality of primary care. We interpret this result as evidence that health-education gradient can be explained, at least in part, by the fact that better educated individuals are more able to process and internalize health related information as provided by GPs

Integrated structure electromagnetic optimization of large space antenna reflectors

The requirements for extremely precise and powerful large space antenna reflectors have motivated the development of a procedure for shape control of the reflector surface. A mathematical optimization procedure has been developed which improves antenna performance while minimizing necessary shape correction effort. In contrast to previous work which proposed controlling the rms distortion error of the surface thereby indirectly improving antenna performance, the current work includes electromagnetic (EM) performance calculations as an integral of the control procedure. The application of the procedure to a radiometer design with a tetrahedral truss backup structure demonstrates the potential for significant improvement. The results indicate the benefit of including EM performance calculations in procedures for shape control of large space antenna reflectors

A First Step for the Molecular Characterization of Neurological Involvement of Behçet Syndrome: an Italian Pivotal Study

Behçet syndrome (BS) is a vasculitis characterized by several clinical manifestations including the rare neurological involvement (neuro-BS, NBS). The aim of our pivotal study was to investigate the mutational status of several inflammation-related genes in a cohort of Italian patients with and without the neurological involvement (20 NBS vs 40 no-NBS patients). The preliminary in silico single nucleotide polymorphism (SNP) selection and primer design were performed by NCBI Primer-Blast tool. Genomic DNA was isolated and amplified using PCR. PCR amplicons were sequenced and bioinformatically analysed. Twelve tagSNPs were selected and genotyped: ERAP1 rs30187, rs17482078, and rs27044; IL10 rs1800872 and rs1518111, IL12A rs17810546, IL23R rs17375018, IL23R-IL12RB2 rs924080, STAT4 rs7572482, CCR1 rs7616215, KLRC4 rs2617170, and UBAC2 rs3825427. ERAP1 and IL23R SNPs showed statistically significant higher frequencies in NBS group than no-NBS. ERAP1 rs30187 AA was more common in no-NBS patients (20.0% NBS vs 47.5% no-NBS; p < 0.05), while rs17482078 GA frequency was higher in NBS patients (55.0% NBS vs 22.5% no-NBS; p < 0.05, OR: 4.21). IL23R rs17375018 GG was more frequent in NBS group (65.0% NBS vs 40.0% no-NBS; p < 0.05), according to a previous finding. No other statistically significant differences were found. In conclusion, ERAP1 and IL23R SNPs were found associated with neurological involvement of BS. Additional and larger analyses were required to verify our preliminary findings

The repayment of unsecured debt by European households

The existing literature that estimates the incidence of arrears relies on either household survey data or administrative data derived from the lender's records of their borrowers. But estimates based on these different sources will give different estimates of arrears. Moreover, the estimates are not useful for policy analysis or for a bank's lending decision, since they ignore the fact that some households do not borrow. The paper discusses the selection issues that are involved in using either source of data and is the first paper to bound the estimate of the household's underlying propensity to repay. To demonstrate the methodology, it uses data from the European Union Survey of Income and Living Conditions survey for 2008 to estimate the factors that affect repayment among Eurozone households

Informal Credit Markets, Judicial Costs and Consumer Credit: Evidence from Firm Level Data

CSEF Working Paper No. 15

Small size boundary effects on two-pion interferometry

The Bose-Einstein correlations of two identically charged pions are derived when these particles, the most abundantly produced in relativistic heavy ion collisions, are confined in finite volumes. Boundary effects on single pion spectrum are also studied. Numerical results emphasize that conventional formulation usually adopted to describe two-pion interferometry should not be used when the source size is small, since this is the most sensitive case to boundary effects. Specific examples are considered for better illustration.Comment: more discussion on Figure4 and diffuse boundar

A Preliminary Analysis of Anthropogenic and Natural Impacts on a Volcanic Lake Ecosystem in Southern Italy by UAV-Based Monitoring

Lakes play an important role in providing various ecosystem services. However, stressors such as climate change, land use, or land-cover change threaten the ecological functions of lakes. National and international legislations address these threats and establish consistent, long-term monitoring schemes. Remote sensing techniques based on the use of Unmanned Aerial Vehicles (UAV) have recently been demonstrated to provide accurate and low-cost spatio-temporal views for the assessment of the ecological status of aquatic ecosystems and the identification of areas at risk of contamination. Few studies have been carried out so far on the employment of these tools in the monitoring of lakes. Therefore, high-resolution UAV surveys were used to analyse and evaluate natural and anthropogenic impacts on the habitat status of a volcanic lake in a protected area. Five UAV flights took place during a year-long cycle (November 2020 to November 2021) in a volcanic lake located in southern Italy. For each flight performance, an orthomosaic of georeferenced RGB images was obtained, and the different features of interest were monitored and quantified using automated processing in a GIS environment. The UAV images made it possible not only to estimate the flooded shores but also to detect the impact of human-made structures and infrastructures on the lagoon environment. It has been possible to observe how the rapid changes in lake-water level have led to the submersion of about 90.000 m(2) of terrain in winter, causing the fragmentation and degradation of habitats, while the connectivity of the natural ecosystem has been threatened by the presence of the road around the lake. The proposed methodology is rather simple and easily replicable by decision makers and local administrators and can be useful for choosing the best restoration interventions

Stem-like and highly invasive prostate cancer cells expressing CD44v8-10 marker originate from CD44-negative cells

In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sorted CD44neg cells rapidly and spontaneously converted to a stable CD44high phenotype specifically expressing the CD44v8-10 isoform which the sorted CD44high subpopulation failed to express. Surprisingly and potentially interesting, in these cells expression of CD44v8-10 was found to be induced in stem cell medium. CD44 variant isoforms are known to be more expressed in CSC and metastatic cells than CD44 standard isoform. In agreement, functional analysis of the two sorted and cultured subpopulations has shown that the CD44v8-10pos PC3 cells, resulting from the conversion of the CD44neg subpopulation, were more invasive in vitro and had a higher clonogenic potential than the sorted CD44high cells, in that they produced mainly holoclones, known to be enriched in stem-like cells. Of interest, the CD44v8-10 is more expressed in human PCa biopsies than in normal gland. The discovery of CD44v8-10pos cells with stem-like and invasive features, derived from a minoritarian CD44neg cell population in PCa, alerts on the high plasticity of stem-like markers and urges for prudency on the approaches to targeting the putative CSC

Overview of experimental results in PbPb collisions at sqrt{s_NN} = 2.76 TeV by the CMS Collaboration

The CMS experiment at the LHC is a general-purpose apparatus with a set of large acceptance and high granularity detectors for hadrons, electrons, photons and muons, providing unique capabilities for both proton-proton and ion-ion collisions. The data collected during the November 2010 PbPb run at sqrt{s_NN} = 2.76 TeV was analyzed and multiple measurements of the properties of the hot and dense matter were obtained. Global event properties, detailed study of jet production and jet properties, isolated photons, quarkonia and weak bosons were measured and compared to pp data and Monte Carlo simulations.Comment: 8 pages, 10 figures, proceedings for Quark Matter 2011, Annecy, France, May 23-28, 201