A Comprehensive Analysis of Password Authentication for Enhancing Security in Internet of Things (Iot)

Recently, there has been a significant increase in customer demands and the variety of services provided due to the increasing use of mobile devices and the development of new networking technologies such as the Internet of Things (IoTs) and Big data networking. The proliferation of future smart cities, smart transport systems, and other Internet of Things (IoT) application areas presents a significant vulnerability to a multitude of security risks that can have detrimental impacts on the economy, the environment, and society. This vast range of functions raises several security concerns, such as data protection, virtualization vulnerabilities, segregation risks, network connectivity issues, and monitoring challenges. The objective of identity and access management is to ensure that the right individuals have access to the right resources. Implementing user identification and identity verification establishes a robust security measure that effectively separates potential attackers from accessing sensitive data. This study use a Systematic Literature Review (SLR) methodology to conduct a comprehensive review of security concerns and various computing approaches to mitigate them. Despite the existence of various approaches to address the specific challenges related to application design, security, and privacy, there is still a need for a comprehensive research study. This study should focus on the challenges and requirements of targeted applications, which currently have limited security enhancement solutions

AN INVESTIGATION OF THE RELATIONSHIP BETWEEN THE LEVEL OF ANTIBIOTIC RESISTANCE OF ESCHERICHIA COLI IN NONTIDAL WETLANDS AND COMMON WETLAND HEALTH FACTORS

This report investigated the prevalence of antibiotic resistance among Escherichia coli in the water of 13 non-tidal mitigation wetlands in Maryland, and its relation to land use and wetland health. At each site, land use, surface and sub-surface water samples, soil samples, and vegetation cover were collected. From the water samples, individual colonies of E. coli were isolated and tested, using the disc diffusion method, for resistance to the antibiotics ampicillin, ciprofloxacin, erythromycin, sulfisoxazole, and tetracycline. According to soils, vegetation and water quality improvement criteria the wetlands function like healthy wetlands. The wetlands' E. coli exhibit resistance to all of the antibiotics tested, except for ciprofloxacin. There were statistically significant relationships found between land use and antibiotic resistance, vegetation, soil and water chemistry. Surprisingly, E. coli in wetlands with smaller stocks of carbon and nitrogen in their soil exhibited more resistance to tetracycline, possibly indicating that soil quality plays an important role in fostering or fighting antibiotic resistance. The work demonstrates that antibiotic resistance is present in Maryland's wetlands, but that its spread could be subdued by healthy wetlands.Maryland Department of Environment, United States Environmental Protection Agenc

Microfluidic Microchannel (Size And Shape) for Single Cell Analysis by Numerical Optimization: Lateral Trapping Method

The primary objective of this work is to show simulation outputs from the developed model of cell flow within a microfluidic device. This work is essential because it requires computational models to offer compact sized biomedical equipment that involves microfluidics technology. Microfluidics has become a common technology for life science applications in latest years. The purpose is to learn the effect of various microchannel size and shape with lateral traps for single cell analysis and to arrive at an optimum design based on a simulation study using COMSOL Multiphysics software. Thus in order to develop software model of various microchannels which execute fluid flow in the microelectronic device. This research provides numerical alternatives from finite element analysissimulation using the software COMSOL-Multiphysics to characterize the shape and size of the microchannel initializing the fluid flow. Optimized design analysis and operating conditions for efficient single cell trap is reported

Application of 3D Zernike descriptors to shape-based ligand similarity searching

Background: The identification of promising drug leads from a large database of compounds is an important step in the preliminary stages of drug design. Although shape is known to play a key role in the molecular recognition process, its application to virtual screening poses significant hurdles both in terms of the encoding scheme and speed. Results: In this study, we have examined the efficacy of the alignment independent three-dimensional Zernike descriptor (3DZD) for fast shape based similarity searching. Performance of this approach was compared with several other methods including the statistical moments based ultrafast shape recognition scheme (USR) and SIMCOMP, a graph matching algorithm that compares atom environments. Three benchmark datasets are used to thoroughly test the methods in terms of their ability for molecular classification, retrieval rate, and performance under the situation that simulates actual virtual screening tasks over a large pharmaceutical database. The 3DZD performed better than or comparable to the other methods examined, depending on the datasets and evaluation metrics used. Reasons for the success and the failure of the shape based methods for specific cases are investigated. Based on the results for the three datasets, general conclusions are drawn with regard to their efficiency and applicability

Enhanced Arctic stratification in a warming scenario: Evidence from the mid pliocene warm Pperiod

Global warming is most pronounced in the Arctic as evident from the massive sea ice loss during the past few decades. The Mid-Pliocene Warm Period (MPWP), 3.264 – 3.025 million years ago with similar CO2 levels, is the nearest analogue for understanding the impacts of future global warming. High-resolution studies of relative nutrient utilization and productivity from the Atlantic-Arctic Gateway (AAG) can provide insight into the nutrient availability governed by stratification strength during past warm climates. Here, we present relative nutrient utilization and productivity variability during the MPWP using sediments collected during the Ocean Drilling Program (ODP) Leg 151 from Fram Strait, AAG. We find that the relative nutrient utilization was high (low) implying stronger (weaker) stratification during warm (cold) periods during the MPWP. Stronger stratification inhibits the nutrient influx from intermediate water depths into the surface leading to higher utilization of available nutrients. It existed during warm periods likely due to enhanced summer sea ice melt and river discharge from the hinterland. As a consequence, the freshened surface layer could have stored more heat and accelerated the sea ice melt further implying that in the present-day warm scenario, stronger stratification and upper layer freshening may lead to more sea ice melt in the Arctic Ocean

Enhanced Arctic Stratification in a Warming Scenario: Evidence from the Mid Pliocene Warm Period

This paper was published by AGU. Copyright (2021) American Geophysical Union.Global warming is most pronounced in the Arctic as evident from the massive sea ice loss during the past few decades. The Mid-Pliocene Warm Period (MPWP), 3.264 – 3.025 million years ago with similar CO2 levels, is the nearest analogue for understanding the impacts of future global warming. High-resolution studies of relative nutrient utilization and productivity from the Atlantic-Arctic Gateway (AAG) can provide insight into the nutrient availability governed by stratification strength during past warm climates. Here, we present relative nutrient utilization and productivity variability during the MPWP using sediments collected during the Ocean Drilling Program (ODP) Leg 151 from Fram Strait, AAG. We find that the relative nutrient utilization was high (low) implying stronger (weaker) stratification during warm (cold) periods during the MPWP. Stronger stratification inhibits the nutrient influx from intermediate water depths into the surface leading to higher utilization of available nutrients. It existed during warm periods likely due to enhanced summer sea ice melt and river discharge from the hinterland. As a consequence, the freshened surface layer could have stored more heat and accelerated the sea ice melt further implying that in the present-day warm scenario, stronger stratification and upper layer freshening may lead to more sea ice melt in the Arctic Ocean

High Level Aminoglycoside Resistance and Distribution of Aminoglycoside Resistant Genes among Clinical Isolates of Enterococcus Species in Chennai, India

Enterococci are nosocomial pathogen with multiple-drug resistance by intrinsic and extrinsic mechanisms. Aminoglycosides along with cell wall inhibitors are given clinically for treating enterococcal infections. 178 enterococcal isolates were analyzed in this study. E. faecalis is identified to be the predominant Enterococcus species, along with E. faecium, E. avium, E. hirae, E. durans, E. dispar and E. gallinarum. High level aminoglycoside resistance (HLAR) by MIC for gentamicin (GM), streptomycin (SM) and both (GM + SM) antibiotics was found to be 42.7%, 29.8%, and 21.9%, respectively. Detection of aminoglycoside modifying enzyme encoding genes (AME) in enterococci was identified by multiplex PCR for aac(6′)-Ie-aph(2′′)-Ia; aph(2′′)-Ib; aph(2′′)-Ic; aph(2′′)-Id and aph(3′)-IIIa genes. 38.2% isolates carried aac(6′)-Ie-aph(2′′)-Ia gene and 40.4% isolates carried aph(3′)-IIIa gene. aph(2′′)-Ib; aph(2′′)-Ic; aph(2′′)-Id were not detected among our study isolates. aac(6′)-Ie-aph(2′′)-Ia and aph(3′)-IIIa genes were also observed in HLAR E. durans, E. avium, E. hirae, and E. gallinarum isolates. This indicates that high level aminoglycoside resistance genes are widely disseminated among isolates of enterococci from Chennai

High level aminoglycoside resistance and distribution of aminoglycoside resistant genes among clinical isolates of Enterococcus species

Enterococci are nosocomial pathogen with multiple-drug resistance by intrinsic and extrinsic mechanisms. Aminoglycosides along with cell wall inhibitors are given clinically for treating enterococcal infections. 178 enterococcal isolates were analyzed in this study. E. faecalis is identified to be the predominant Enterococcus species, along with E. faecium, E. avium, E. hirae, E. durans, E. dispar and E. gallinarum. High level aminoglycoside resistance (HLAR) by MIC for gentamicin (GM), streptomycin (SM) and both (GM + SM) antibiotics was found to be 42.7%, 29.8%, and 21.9%, respectively. Detection of aminoglycoside modifying enzyme encoding genes (AME) in enterococci was identified by multiplex PCR for aa

Oxygen isotope-salinity relation in an Arctic fjord (Kongsfjorden): Implications to hydrographic variability

The global warming leads to a large freshwater influx into the Arctic Ocean, which has adverse implications to the sea-ice dynamics, ocean circulation, and acidification. The relationship between oxygen isotope ratio (δ18O) and salinity (S) is helpful in exploring various hydrographic processes related to the freshwater influx and is also required to accurately determine past salinity variability using oxygen isotope ratio of the carbonates. In view of this, systematic measurements of δ18O and salinity of water from an Arctic fjord (Kongsfjorden) were carried out during the summer season of 2013. Until now, the relationships between δ18O and salinity from such fjords were based on a limited number of samples collected during a very short span of time and thus may not accurately represent the long-term conditions prevailing in the fjord. The present study determines a more representative δ18O–salinity relationship as water samples from different depths and location over a long period were systematically collected. The water samples were collected from four different locations at different depths along the axis of the fjord representing the inner and outer fjords. The inner stations (I-8 and I-6) exhibit lower δ18O values than the outer stations (I-1 and I-3), which indicate the higher influence of freshwater from glacial melting in the inner stations. The δ18O–salinity relationship from the inner and outer fjords yield a slope of 0.54 (r2 = 0.67, n = 56) and 0.39 (r2 = 0.66, n = 68), respectively. The δ18O of freshwater influx in the fjord is estimated at –18.4‰, which is close to the widely accepted freshwater-δ18O value of the Arctic basin. The δ18O of glacial discharge, which is the largest source of freshwater influx to the fjord, is estimated at ca. –21.0‰, which will be useful for future freshwater budget calculations. Keywords: Arctic, Fjord, Oxygen isotopes, Salinity, Freshwater, Meltin