The Logic & Limits of the Exceptional Circumstances Test in Magill and IMS Health

In this Article, we show that, in contrast to the Commission\u27s balancing approach in Microsoft, the ECJ\u27s narrow construction of the obligation to license IP under Article 82 of the EC Treaty is based on sound economics and constitutes appropriate public policy. The set of “exceptional circumstances” listed in Magill and IMS Health constitutes a reasonable implementation of the optimal legal standard for the assessment of refusals to licence IP: modified per se legality. In the IP context, an obligation to make property available is a requirement for compulsory licensing. The ECJ test limits compulsory licensing to those situations in which the prospective social benefits of licensing are large, while the negative effects of reducing the incentives to innovate are small. The ECJ test ensures that intervention is restricted to cases where the intervention is still likely to increase social welfare. The Commission\u27s test in Microsoft, being a balancing test, does not. As noted by Professor Gerardin, “balancing ex ante vs. ex post efficiencies is obviously a very difficult process, which even the most sophisticated economists may find daunting. The risk of mistaken decisions is therefore high.

Interactions between Silica Particles in the Presence of Multivalent Coions

Forces between charged silica particles in solutions of multivalent coions are measured with colloidal probe technique based on atomic force microscopy. The concentration of 1:z electrolytes is systematically varied to understand the behavior of electrostatic interactions and double-layer properties in these systems. Although the coions are multivalent the Derjaguin, Landau, Verwey, and Overbeek (DLVO) theory perfectly describes the measured force profiles. The diffuse-layer potentials and regulation properties are extracted from the forces profiles by using the DLVO theory. The dependencies of the diffuse-layer potential and regulation parameter shift to lower concentration with increasing coion valence when plotted as a function of concentration of 1:z salt. Interestingly, these profiles collapse to a master curve if plotted as a function of monovalent counterion concentration

A short review of "DGP Specteroscopy"

In this paper we provide a short review of the main results developed in hep-th/0604086. We focus on linearised vacuum perturbations about the self-accelerating branch of solutions in the DGP model. These are shown to contain a ghost in the spectrum for any value of the brane tension. We also comment on hep-th/0607099, where some counter arguments have been presented.Comment: Minor typos correcte

Synergistic Gravity and the Role of Resonances in GRS-Inspired Braneworlds

We consider 5D braneworld models of quasi-localized gravity in which 4D gravity is reproduced at intermediate scales while the extra dimension opens up at both the very short and the very long distances, where the geometry is flat. Our main interest is the interplay between the zero mode of these models, whenever a normalizable zero mode exists, and the effects of zero energy graviton resonant modes coming from the contributions of massive KK modes. We first consider a compactified version of the GRS model and find that quasi-localized gravity is characterized by a scale for which both the resonance and the zero mode have significant contribution to 4D gravity. Above this scale, gravity is primarily mediated by the zero mode, while the resonance gives only minor corrections. Next, we consider an asymmetric version of the standard non-compact GRS model, characterized by different cosmological constants on each AdS side. We show that a resonance is present but the asymmetry, through the form of the localizing potential, can weaken it, resulting in a shorter lifetime and, thus, in a shorter distance scale for 4D gravity. As a third model exhibiting quasi-localization, we consider a version of the GRS model in which the central positive tension brane has been replaced by a configuration of a scalar field propagating in the bulk.Comment: 18 pages, 3 figures, added 1 figure, revised version as published in Class. Quant. Gra

The Colombian conflict: a description of a mental health program in the Department of Tolima.

Colombia has been seriously affected by an internal armed conflict for more than 40 years affecting mainly the civilian population, who is forced to displace, suffers kidnapping, extortion, threats and assassinations. Between 2005 and 2008, Médecins Sans Frontières-France provided psychological care and treatment in the region of Tolima, a strategic place in the armed conflict. The mental health program was based on a short-term multi-faceted treatment developed according to the psychological and psychosomatic needs of the population. Here we describe the population attending during 2005-2008, in both urban and rural settings, as well as the psychological treatment provided during this period and its outcomes.We observed differences between the urban and rural settings in the traumatic events reported, the clinical expression of the disorders, the disorders diagnosed, and their severity. Although the duration of the treatment was limited due to security reasons and access difficulties, patient condition at last visit improved in most of the patients. These descriptive results suggest that further studies should be conducted to examine the role of short-term psychotherapy, adapted specifically to the context, can be a useful tool to provide psychological care to population affected by an armed conflict

Stealth Acceleration and Modified Gravity

We show how to construct consistent braneworld models which exhibit late time acceleration. Unlike self-acceleration, which has a de Sitter vacuum state, our models have the standard Minkowski vacuum and accelerate only in the presence of matter, which we dub ``stealth-acceleration''. We use an effective action for the brane which includes an induced gravity term, and allow for an asymmetric set-up. We study the linear stability of flat brane vacua and find the regions of parameter space where the set-up is stable. The 4-dimensional graviton is only quasi-localised in this set-up and as a result gravity is modified at late times. One of the two regions is strongly coupled and the scalar mode is eaten up by an extra symmetry that arises in this limit. Having filtered the well-defined theories we then focus on their cosmology. When the graviton is quasi-localised we find two main examples of acceleration. In each case, we provide an illustrative model and compare it to LambdaCDM.Comment: 32 pages, 5 figure

Development of fad7-1 single mutant Arabidopsis thaliana plants that are resistant to aphids

Aphids are a group of sap-feeding insects that attack most of the world’s crops. The loss of function of fatty acid desaturase7 (FAD7) in Solanum lycopersicum (tomato plant) induces aphid resistance that is dependent upon the accumulation of plant defense hormones such as salicylic acid (SA). Tomato lacks most of the genetic resources found in the model plant Arabidopsis (Arabidopsis thaliana). There is an analogous fad7-1 line of Arabidopsis; however, the line has a background mutation, the glabra-1 (gl1), that causes the absence of trichomes (small hairs), which are essential to plant defense. In order to study aphid resistance, a single mutant line of fad7-1 mutants were developed using cross breeding between the fad7-1/gl1 mutant and wild-type plants. Homozygous fad7-1 mutants were then identified using the Kasajima DNA extraction method, followed by the use of single nucleotide polymorphism-polymerase chain reaction (SNP-PCR) primers using allele-specific PCR. A phenotypic screening was then performed to screen out the plants with the glabra-1 mutation using the presence or absence of trichomes. Two single Arabidopsis fad7-1 mutant lines were identified, and subsequently verified using a bioassay to be aphid resistant relative to other genotypes as seen in tomato

CCAAT-Binding Factor as a Transcriptional Regulator of CYC1 in Candida albicans

Candida albicans is a normal commensal of the human flora; however, under appropriate circumstances this organism can become pathogenic to the host and cause life threatening conditions. In fact, Candida species are the fourth most common nosocomial infection in the Unites States with a mortality rate of over 30% The CCAAT binding factor is a multi-protein transcription factor highly conserved in eukaryotes. It binds specifically to the consensus sequence 5\u27-CCAAT-3\u27 in promoters and it is one of the most common cisacting elements in eukaryotes promoters. This transcription factor is composed of three DNA binding subunits; Hap2p, Hap3p and Hap5. In yeast and fungi a fourth subunit, termed Hap4, functions as the effector subunit that regulates the expression of target genes. C. albicans has been found to have multiple genes encoding some of the proteins associated with the CCAAT-binding factor, namely Hap31 and Hap32 as well as Hap41, Hap42, and Hap43. In the studies described in this dissertation, the role of the CCAAT-binding factor in the regulation of CYC1, encoding cytochrome c, was examined. It was found that the CCAAT-binding factor was the sole transcription factor involved in CYC1 transcriptional regulation. It was found that Hap31 functions to activate CYC1 transcription in an iron rich environment, while Hap32 represses CYC1 transcription when iron is limited. Thus, the differentially utilization of Hap31 and Hap32 serves as a molecular switch to convert a transcriptional activator to a repressor in response to environmental signals. It was also shown that HAP32 contains a 118-nucleotide intron that is removed during processing; however, the splicing event was not regulated by iron availability. Additional studies were done to construct a hem1Δ homozygous mutant of C. albicans and this mutant was used to demonstrate that C. albicans can acquire iron, in the form of heme, exogenously. We also examined the growth of the hem1Δ homozygote under anaerobiosis and discovered that the mutant requires a source of unsaturated fatty acids for anaerobic growth; however, it does not require supplementation with exogenous ergosterol, common in many other fungi. The clinical implications of this finding will be discussed

Entangled spinning particles in charged and rotating black holes

Spin precession for an EPR pair of spin-1/2 particles in equatorial orbits around a Kerr-Newman black hole is studied. Hovering observers are introduced to ensure fixed reference frames in order to perform the Wigner rotation. These observers also guarantee a reliable direction to compare spin states in rotating black holes. The velocity of the particle due frame-dragging is explicitly incorporated by addition of velocities with respect the hovering observers and the corresponding spin precession angle is computed. The spin-singlet state is observed to be mixed with the spin-triplet by dynamical and gravity effects, thus it is found that a perfect anti-correlation of entangled states for these observers is deteriorated. Finally, an analysis concerning the different limit cases of parameters of spin precession including the frame-dragging effects is carried out.Comment: 25+1 pages, 7 eps figures. Major changes were made through all the manuscript. Clarifications regarding modifications were introduced through the draft. Figures were changed and reduced in number. arXiv admin note: text overlap with arXiv:quant-ph/030711