9 research outputs found

    Islet amyloid polypeptide: Identification and chromosomal localization of the human gene

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    Abstract Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12

    The Local Lesion Response

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    Viral Determinants of Resistance Versus Susceptibility

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    Regulation of mammalian LINE1 retrotransposon transcription

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