15 research outputs found

    Introduction to “A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2014 Updates”

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    Abstract Since the publication of "A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals" in 2008, prevention of healthcare-associated infections (HAIs) has become a national priority. Despite improvements, preventable HAIs continue to occur. The 2014 updates to the Compendium were created to provide acute care hospitals with up-to-date, practical, expert guidance to assist in prioritizing and implementing their HAI prevention efforts. It is the product of a highly collaborative effort led by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), the American Hospital Association (AHA), the Association for Professionals in Infection Control and Epidemiology (APIC), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise, including the Centers for Disease Control and Prevention (CDC), the Institute for Healthcare Improvement (IHI), the Pediatric Infectious Diseases Society (PIDS), the Society for Critical Care Medicine (SCCM), the Society for Hospital Medicine (SHM), and the Surgical Infection Society (SIS)

    LÀndliche LebensverhÀltnisse im Wandel 1952, 1972, 1993, 2012: Volume 3, Kindheit im Wandel

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    Wie hat sich die Kindheit im dörflichen Raum gewandelt? Wie beurteilen die Kinder ihre aktuelle Lebenssituation? Wie beurteilen die Eltern die Lebenssituation ihrer Kinder? Welche Muster des Aufwachsens zeigen sich im lÀndlichen Raum? Das sind die Forschungsfragen, denen im Rahmen der LÀngsschnittstudie 'LÀndliche Lebensver-hÀltnisse im Wandel 1952, 1972, 1993 und 2012' in der Teilstudie zu Kindheit im lÀndlichen Raum durch ForscherInnen der Bergischen UniversitÀt Wuppertal nachgegangen werden konnte. Somit konnten Daten zu vergangenen Kindheiten in historisch-zeitlicher Perspektive und Daten zur aktuellen Kindheit aus der Perspektive der 5- bis 13-jÀhrigen Kinder im lÀndlichen Raum erhoben und ausgewertet werden. [...]How has childhood in rural areas changed? How do children judge on their current living conditions? How do parents judge on their children's living conditions? Which patterns of growing up occur in rural areas? These are the research questions which could be pursued by researchers form Bergische UniversitÀt Wuppertal in the context of the longitudinal study 'LÀndliche LebensverhÀltnisse im Wandel 1952, 1972, 1993 and 2012 (Changing Living Conditions in Rural Areas 1952, 1972, 1993 and 2012)', here: sub-study on childhood in rural areas. The study allowed for collecting and assessing data on past childhoods from a historical-chronological perspective as well as data on current childhood from the perspective of children at the age of 5-13 in rural areas. [...

    Analysis of allele-specific RNA transcription in FSHD by RNA-DNA FISH in single myonuclei

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    Autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) is likely caused by epigenetic alterations in chromatin involving contraction of the D4Z4 repeat array near the telomere of chromosome 4q. The precise mechanism by which deletions of D4Z4 influence gene expression in FSHD is not yet resolved. Regulatory models include a cis effect on proximal gene transcription (position effect), DNA looping, non-coding RNA, nuclear localization and trans-effects. To directly test whether deletions of D4Z4 affect gene expression in cis, nascent RNA was examined in single myonuclei so that transcription from each allele could be measured independently. FSHD and control myotubes (differentiated myoblasts) were subjected to sequential RNA–DNA FISH. A total of 16 genes in the FSHD region (FRG2, TUBB4Q, FRG1, FAT1, F11, KLKB1, CYP4V2, TLR3, SORBS2, PDLIM3 (ALP), LRP2BP, ING2, SNX25, SLC25A4 (ANT1), HELT and IRF2) were examined for interallelic variation in RNA expression within individual myonuclei. Sequential DNA hybridization with a unique 4q35 chromosome probe was then applied to confirm the localization of nascent RNA to 4q. A D4Z4 probe, labeled with a third fluorochrome, distinguished between the deleted and normal allele in FSHD nuclei. Our data do not support an FSHD model in which contracted D4Z4 arrays induce altered transcription in cis from 4q35 genes, even for those genes (FRG1, FRG2 and SLC25A4 (ANT1)) for which such an effect has been proposed

    A compendium of strategies to prevent healthcare-associated infections in acute care hospitals: 2014 updates.

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    Since the publication of "A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals" in 2008, prevention of healthcare-associated infections (HAIs) has become a national priority. Despite improvements, preventable HAIs continue to occur. The 2014 updates to the Compendium were created to provide acute care hospitals with up-to-date, practical, expert guidance to assist in prioritizing and implementing their HAI prevention efforts. They are the product of a highly collaborative effort led by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), the American Hospital Association (AHA), the Association for Professionals in Infection Control and Epidemiology (APIC), and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise, including the Centers for Disease Control and Prevention (CDC), the Institute for Healthcare Improvement (IHI), the Pediatric Infectious Diseases Society (PIDS), the Society for Critical Care Medicine (SCCM), the Society for Hospital Medicine (SHM), and the Surgical Infection Society (SIS)
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