Co-Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia : Results From a UK National Register

The British Society for Rheumatology (BSR) Biologics Register in Ankylosing Spondylitis is funded by the BSR and they have receive funds for this from Pfizer, AbbVie and UCB. These companies receive advance copies of manuscripts and can provide comments but have no input into determining the topics for analysis, publication and no input into the work involved in this analysis. This analysis is part-funded by Arthritis Research UK (Grant No: 21378)Peer reviewedPublisher PD

Optical and Infrared Spectroscopy of the type IIn SN 1998S : Days 3-127

We present contemporary infrared and optical spectroscopic observations of the type IIn SN 1998S for the period between 3 and 127 days after discovery. In the first week the spectra are characterised by prominent broad emission lines with narrow peaks superimposed on a very blue continuum(T~24000K). In the following two weeks broad, blueshifted absorption components appeared in the spectra and the temperature dropped. By day 44, broad emission components in H and He reappeared in the spectra. These persisted to 100-130d, becoming increasingly asymmetric. We agree with Leonard et al. (2000) that the broad emission lines indicate interaction between the ejecta and circumstellar material (CSM) and deduce that progenitor of SN 1998S appears to have gone through at least two phases of mass loss, giving rise to two CSM zones. Examination of the spectra indicates that the inner zone extended to <90AU, while the outer CSM extended from 185AU to over 1800AU. Analysis of high resolution spectra shows that the outer CSM had a velocity of 40-50 km/s. Assuming a constant velocity, we can infer that the outer CSM wind commenced more than 170 years ago, and ceased about 20 years ago, while the inner CSM wind may have commenced less than 9 years ago. During the era of the outer CSM wind the outflow was high, >2x10^{-5}M_{\odot}/yr corresponding to a mass loss of at least 0.003M_{\odot} and suggesting a massive progenitor. We also model the CO emission observed in SN 1998S. We deduce a CO mass of ~10^{-3} M_{\odot} moving at ~2200km/s, and infer a mixed metal/He core of ~4M_{\odot}, again indicating a massive progenitor.Comment: 22 pages, 14 figures, accepted in MNRA

Subaru Spectroscopy and Spectral Modeling of Cygnus A

We present high angular resolution ($\sim$0.5$^\prime$$^\prime$) MIR spectra of the powerful radio galaxy, Cygnus A, obtained with the Subaru telescope. The overall shape of the spectra agree with previous high angular resolution MIR observations, as well as previous Spitzer spectra. Our spectra, both on and off nucleus, show a deep silicate absorption feature. The absorption feature can be modeled with a blackbody obscured by cold dust or a clumpy torus. The deep silicate feature is best fit by a simple model of a screened blackbody, suggesting foreground absorption plays a significant, if not dominant role, in shaping the spectrum of Cygnus A. This foreground absorption prevents a clear view of the central engine and surrounding torus, making it difficult to quantify the extent the torus attributes to the obscuration of the central engine, but does not eliminate the need for a torus in Cygnus A

The complexity of parsec-scaled dusty tori in AGN

Warm gas and dust surround the innermost regions of active galactic nuclei (AGN). They provide the material for accretion onto the super-massive black hole and they are held responsible for the orientation-dependent obscuration of the central engine. The AGN-heated dust distributions turn out to be very compact with sizes on scales of about a parsec in the mid-infrared. Only infrared interferometry currently provides the necessary angular resolution to directly study the physical properties of this dust. Size estimates for the dust distributions derived from interferometric observations can be used to construct a size--luminosity relation for the dust distributions. The large scatter about this relation suggests significant differences between the dust tori in the individual galaxies, even for nuclei of the same class of objects and with similar luminosities. This questions the simple picture of the same dusty doughnut in all AGN. The Circinus galaxy is the closest Seyfert 2 galaxy. Because its mid-infrared emission is well resolved interferometrically, it is a prime target for detailed studies of its nuclear dust distribution. An extensive new interferometric data set was obtained for this galaxy. It shows that the dust emission comes from a very dense, disk-like structure which is surrounded by a geometrically thick, similarly warm dust distribution as well as significant amounts of warm dust within the ionisation cone.Comment: 8 pages, 3 figures, to appear in the proceedings of the conference "The central kiloparsec in Galactic Nuclei: Astronomy at High Angular Resolution 2011", open access Journal of Physics: Conference Series (JPCS), published by IOP Publishin

Differential induction of apaptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent

Phenethyl isothiocyanate (PEITC) is a naturally occurring electrophile which depletes intracellular glutathione (GSH) levels and triggers accumulation of reactive oxygen species (ROS). PEITC is of considerable interest as a potential chemopreventive/chemotherapeutic agent, and in this work, we have investigated the effects of PEITC on human breast cancer cell lines. Whereas PEITC readily induced apoptosis in MDA-MB-231 cells (associated with rapid activation of caspases 9 and 3, and decreased expression of BAX), MCF7 cells were relatively resistant to the apoptosis promoting effects of PEITC. The relative resistance of MCF7 cells was associated with high basal expression of NRF2, a transcription factor that coordinates cellular protective responses to oxidants and electrophiles and raised intracellular levels of GSH. This raised basal expression of NRF2 appeared to be a response to on-going production of ROS, since treatment with the antioxidant and GSH precursor N-acetylcysteine (NAC) reduced NRF2 expression. Moreover, pre-treatment of MDA-MB-231 cells with NAC rendered these cells relatively resistant to PEITC-induced apoptosis. In summary, our data confirm that PEITC may be an effective chemopreventive/therapeutic agents for breast cancer. However, differences in the basal expression of NRF2 and resultant changes in GSH levels may be an important determinant of sensitivity to PEITC-induced apoptosis

Association of the CCR5 gene with juvenile idiopathic arthritis

The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction. A 32 base-pair insertion/deletion variant (CCR5Δ32) within the gene leads to a frame shift and a nonfunctional receptor. CCR5Δ32 has been investigated for its association with juvenile idiopathic arthritis (JIA), with conflicting results. The aim of this study was to investigate whether CCR5Δ32 is associated with JIA in an UK population. CCR5Δ32 was genotyped in JIA cases (n=1054) and healthy controls (n=3129) and genotype and allele frequencies were compared. A meta-analysis of our study combined with previously published studies was performed. CCR5Δ32 was significantly associated with protection from developing JIA, in this UK data set (P(trend)=0.006, odds ratio (OR) 0.79 95% confidence interval (95% CI): 0.66-0.94). The meta-analysis of all published case-control association studies confirmed the protective association with JIA (P=0.001 OR 0.82 95% CI: 0.73-0.93). CCR5Δ32 is a functional variant determining the number of receptors on the surface of T cells, and it is hypothesized that the level of CCR5 expression could influence the migration of proinflammatory T cells into the synovium and thus susceptibility to JIA

ALMA polarimetry measures magnetically aligned dust grains in the torus of NGC 1068

The obscuring structure surrounding active galactic nuclei (AGN) can be explained as a dust and gas flow cycle that fundamentally connects the AGN with their host galaxies. This structure is believed to be associated with dusty winds driven by radiation pressure. However, the role of magnetic fields, which are invoked in almost all models for accretion onto a supermassive black hole and outflows, is not thoroughly studied. Here we report the first detection of polarized thermal emission by means of magnetically aligned dust grains in the dusty torus of NGC 1068 using ALMA Cycle 4 polarimetric dust continuum observations ($0.07"$, $4.2$ pc; 348.5 GHz, $860$ $\mu$m). The polarized torus has an asymmetric variation across the equatorial axis with a peak polarization of $3.7\pm0.5$\% and position angle of $109\pm2^{\circ}$ (B-vector) at $\sim8$ pc east from the core. We compute synthetic polarimetric observations of magnetically aligned dust grains assuming a toroidal magnetic field and homogeneous grain alignment. We conclude that the measured 860 $\mu$m continuum polarization arises from magnetically aligned dust grains in an optically thin region of the torus. The asymmetric polarization across the equatorial axis of the torus arises from 1) an inhomogeneous optical depth, and 2) a variation of the velocity dispersion, i.e. variation of the magnetic field turbulence at sub-pc scales, from the eastern to the western region of the torus. These observations and modeling constrain the torus properties beyond spectral energy distribution results. This study strongly supports that magnetic fields up to a few pc contribute to the accretion flow onto the active nuclei.Comment: 19 pages, 11 figures (Accepted for Publication to ApJ

High Energy gamma-rays From FR I Jets

Thanks to Hubble and Chandra telescopes, some of the large scale jets in extragalactic radio sources are now being observed at optical and X-ray frequencies. For the FR I objects the synchrotron nature of this emission is surely established, although a lot of uncertainties - connected for example with the particle acceleration processes involved - remain. In this paper we study production of high energy gamma-rays in FR I kiloparsec-scale jets by inverse-Compton emission of the synchrotron-emitting electrons. We consider different origin of seed photons contributing to the inverse-Compton scattering, including nuclear jet radiation as well as ambient, stellar and circumstellar emission of the host galaxies. We discuss how future detections or non-detections of the evaluated gamma-ray fluxes can provide constraints on the unknown large scale jet parameters, i.e. the magnetic field intensity and the jet Doppler factor. For the nearby sources Centaurus A and M 87, we find measurable fluxes of TeV photons resulting from synchrotron self-Compton process and from comptonisation of the galactic photon fields, respectively. In the case of Centaurus A, we also find a relatively strong emission component due to comptonisation of the nuclear blazar photons, which could be easily observed by GLAST at energy ~10 GeV, providing important test for the unification of FR I sources with BL Lac objects.Comment: 39 pages, 6 figures included. Modified version, accepted for publication in Astrophysical Journa