High Resolution Imaging of the Magnetic Field in the central parsec of the Galaxy

We discuss a high resolution (FWHM~ 0.45 arcsec) image of the emissive polarization from warm dust in the minispiral in the Galactic Centre and discuss the implications for the magnetic field in the dusty filaments. The image was obtained at a wavelength of 12.5 microns with the CanariCam multimode mid-infrared imager on the Gran Telescopio Canarias. It confirms the results obtained from previous observations but also reveals new details of the polarization structures. In particular, we identify regions of coherent magnetic field emission at position angles of ~45 deg to the predominantly north--south run of field lines in the Northern Arm which may be related to orbital motions inclined to the general flow of the Northern Arm. The luminous stars that have been identified as bow-shock sources in the Northern Arm do not disrupt or dilute the field but are linked by a coherent field structure, implying that the winds from these objects may push and compress the field but do not overwhelm it. The magnetic field in the the low surface brightness regions in the East-West Bar to the south of SgrA* lies along the Bar, but the brighter regions generally have different polarization position angles, suggesting that they are distinct structures. In the region of the Northern Arm sampled here, there is only a weak correlation between the intensity of the emission and the degree of polarization. This is consistent with saturated grain alignment where the degree of polarization depends on geometric effects, including the angle of inclination of the field to the line of sight and superposition of filaments with different field directions, rather than the alignment efficiency.Comment: 9 pages, 3 figures, Proceedings of Cosmic Dust X, held in Mitaka, Japan in August 201

Silicate absorption in heavily obscured galaxy nuclei

Spectroscopy at 8-13 microns with T-ReCS on Gemini-S is presented for 3 galaxies with substantial silicate absorption features, NGC 3094, NGC 7172 and NGC 5506. In the galaxies with the deepest absorption bands, the silicate profile towards the nuclei is well represented by the emissivity function derived from the circumstellar emission from the red supergiant, mu Cephei which is also representative of the mid-infrared absorption in the diffuse interstellar medium in the Galaxy. There is spectral structure near 11.2 microns in NGC 3094 which may be due to a component of crystalline silicates. In NGC 5506, the depth of the silicate absorption increases from north to south across the nucleus, suggestive of a dusty structure on scales of 10s of parsecs. We discuss the profile of the silicate absorption band towards galaxy nuclei and the relationship between the 9.7 micron silicate and 3.4 micron hydrocarbon absorption bands.Comment: 7 pages, accepted for publication in MNRA

Distribution of dust clouds around the central engine of NGC 1068

We studied the distribution of dust clouds around the central engine of NGC 1068 based on shifted-and-added 8.8 - 12.3 micron (MIR) multi-filter images and 3.0 - 3.9 micron (L-band) spectra obtained with the Subaru Telescope. In a region of 100 pc (1.4") around the central peak, we successfully constructed maps of color temperatures and emissivities of the MIR and L-band continua as well as the 9.7 micron and 3.4 micron dust features with spatial resolutions of 26 pc (0.37") in the MIR and 22 pc (0.3") in the L-band. Our main results are: 1) color temperature of the MIR continuum scatters around the thermal equilibrium temperature with the central engine as the heat source while that of the L-band continuum is higher and independent upon distance from the central engine; 2) the peak of the 9.7 micron silicate absorption feature is shifted to a longer wavelength at some locations; 3) the ratio of the optical depths of the dust features is different from the Galactic values and show complicated spatial distribution; and 4) there is a pie shaped warm dust cloud as an enhancement in the emissivity of the MIR continuum extending about 50 pc to the north from the central engine. We speculate that material falls into the central engine through this cloud.Comment: 26 pages, 9 figures. Accepted for publication on Ap

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells

Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors. Here we report cyclo-CLLFVY, identified from a library of 3.2 million cyclic hexapeptides using a genetically encoded high-throughput screening platform, as an inhibitor of the HIF-1α/HIF-1β protein-protein interaction in vitro and in cells. The identified compound inhibits HIF-1 dimerization and transcription activity by binding to the PAS-B domain of HIF-1α, reducing HIF-1-mediated hypoxia response signaling in a variety of cell lines, without affecting the function of the closely related HIF-2 isoform. The reported cyclic peptide demonstrates the utility of our high-throughput screening platform for the identification of protein-protein interaction inhibitors, and forms the starting point for the development of HIF-1 targeted cancer therapeutics

Near-Infrared Polarimetric Adaptive Optics Observations of NGC 1068: A torus created by a hydromagnetic outflow wind

We present J' and K' imaging linear polarimetric adaptive optics observations of NGC 1068 using MMT-Pol on the 6.5-m MMT. These observations allow us to study the torus from a magnetohydrodynamical (MHD) framework. In a 0.5" (30 pc) aperture at K', we find that polarisation arising from the passage of radiation from the inner edge of the torus through magnetically aligned dust grains in the clumps is the dominant polarisation mechanism, with an intrinsic polarisation of 7.0%$\pm$2.2%. This result yields a torus magnetic field strength in the range of 4$-$82 mG through paramagnetic alignment, and 139$^{+11}_{-20}$ mG through the Chandrasekhar-Fermi method. The measured position angle (P.A.) of polarisation at K$'$ is found to be similar to the P.A. of the obscuring dusty component at few parsec scales using infrared interferometric techniques. We show that the constant component of the magnetic field is responsible for the alignment of the dust grains, and aligned with the torus axis onto the plane of the sky. Adopting this magnetic field configuration and the physical conditions of the clumps in the MHD outflow wind model, we estimate a mass outflow rate $\le$0.17 M$_{\odot}$ yr$^{-1}$ at 0.4 pc from the central engine for those clumps showing near-infrared dichroism. The models used were able to create the torus in a timescale of $\geq$10$^{5}$ yr with a rotational velocity of $\leq$1228 km s$^{-1}$ at 0.4 pc. We conclude that the evolution, morphology and kinematics of the torus in NGC 1068 can be explained within a MHD framework.Comment: 14 pages, 4 figures, Accepted by MNRA

The Mid-Infrared Emission of M87

We discuss Subaru and Spitzer Space Telescope imaging and spectroscopy of M87 in the mid-infrared from 5-35 um. These observations allow us to investigate mid-IR emission mechanisms in the core of M87 and to establish that the flaring, variable jet component HST-1 is not a major contributor to the mid-IR flux. The Spitzer data include a high signal-to-noise 15-35 $\mu$m spectrum of the knot A/B complex in the jet, which is consistent with synchrotron emission. However, a synchrotron model cannot account for the observed {\it nuclear} spectrum, even when contributions from the jet, necessary due to the degrading of resolution with wavelength, are included. The Spitzer data show a clear excess in the spectrum of the nucleus at wavelengths longer than 25 um, which we model as thermal emission from cool dust at a characteristic temperature of 55 \pm 10 K, with an IR luminosity \sim 10^{39} {\rm ~erg ~s^{-1}}. Given Spitzer's few-arcsecond angular resolution, the dust seen in the nuclear spectrum could be located anywhere within ~5'' (390 pc) of the nucleus. In any case, the ratio of AGN thermal to bolometric luminosity indicates that M87 does not contain the IR-bright torus that classical unified AGN schemes invoke. However, this result is consistent with theoretical predictions for low-luminosity AGNsComment: 9 pages, 7 figures, ApJ, in pres

Unveiling the Active Nucleus of Centaurus A

We report new HST WFPC2 and NICMOS observations of the center of the nearest radio galaxy Centaurus A (NGC 5128) and discuss their implications for our understanding of the active nucleus and jet. We detect the active nucleus in the near-IR (K and H) and, for the first time, in the optical (I and V), deriving the spectral energy distribution of the nucleus from the radio to X-rays. The optical and part of the near-IR emission can be explained by the extrapolation of the X-ray power law reddened by A_V~14mag, a value consistent with other independent estimates. The 20pc-scale nuclear disk discovered by Schreier et al. (1998) is detected in the [FeII] 1.64mic line and presents a morphology similar to that observed in Pa alpha with a [FeII]/Pa alpha ratio typical of low ionization Seyfert galaxies and LINERs. NICMOS 3 Pa alpha observations in a 50"x50" circumnuclear region suggest enhanced star formation (~0.3Msun/yr) at the edges of the putative bar seen with ISO, perhaps due to shocks driven into the gas. The light profile, reconstructed from V, H and K observations, shows that Centaurus A has a core profile with a resolved break at ~4" and suggests a black--hole mass of ~10^9 Msun. A linear blue structure aligned with the radio/X-ray jet may indicate a channel of relatively low reddening in which dust has been swept away by the jet.Comment: 19 pages, 13 figures, Astrophysical Journal, in press. High quality figures available at http://www.arcetri.astro.it/~marconi/colpic.htm

Mid-infrared imaging- and spectro-polarimetric subarcsecond observations of NGC 1068

We present sub-arcsecond 7.5$-$13 $\mu$m imaging- and spectro-polarimetric observations of NGC 1068 using CanariCam on the 10.4-m Gran Telescopio CANARIAS. At all wavelengths, we find: (1) A 90 $\times$ 60 pc extended polarized feature in the northern ionization cone, with a uniform $\sim$44$^{\circ}$ polarization angle. Its polarization arises from dust and gas emission in the ionization cone, heated by the active nucleus and jet, and further extinguished by aligned dust grains in the host galaxy. The polarization spectrum of the jet-molecular cloud interaction at $\sim$24 pc from the core is highly polarized, and does not show a silicate feature, suggesting that the dust grains are different from those in the interstellar medium. (2) A southern polarized feature at $\sim$9.6 pc from the core. Its polarization arises from a dust emission component extinguished by a large concentration of dust in the galaxy disc. We cannot distinguish between dust emission from magnetically aligned dust grains directly heated by the jet close to the core, and aligned dust grains in the dusty obscuring material surrounding the central engine. Silicate-like grains reproduce the polarized dust emission in this feature, suggesting different dust compositions in both ionization cones. (3) An upper limit of polarization degree of 0.3 per cent in the core. Based on our polarization model, the expected polarization of the obscuring dusty material is $\lesssim$0.1 per cent in the 8$-$13 $\mu$m wavelength range. This low polarization may be arising from the passage of radiation through aligned dust grains in the shielded edges of the clumps.Comment: 17 pages, 10 figures, accepted for publication at MNRA

Spectropolarimetry of the 3.4 micron absorption feature in NGC 1068

In order to test the silicate-core/organic-mantle model of galactic interstellar dust, we have performed spectropolarimetry of the 3.4 micron C-H bond stretch that is characteristic of aliphatic hydrocarbons, using the nucleus of the Seyfert 2 galaxy, NGC 1068, as a bright, dusty background source. Polarization calculations show that, if the grains in NGC 1068 had the properties assigned by the core-mantle model to dust in the galactic diffuse ISM, they would cause a detectable rise in polarization over the 3.4 micron feature. No such increase is observed. We discuss modifications to the basic core-mantle model, such as changes in grain size or the existence of additional non-hydrocarbon aligned grain populations, which could better fit the observational evidence. However, we emphasize that the absence of polarization over the 3.4 micron band in NGC 1068 - and, indeed, in every line of sight examined to date - can be readily explained by a population of small, unaligned carbonaceous grains with no physical connection to the silicates.Comment: ApJ, accepte

The complexity of parsec-scaled dusty tori in AGN

Warm gas and dust surround the innermost regions of active galactic nuclei (AGN). They provide the material for accretion onto the super-massive black hole and they are held responsible for the orientation-dependent obscuration of the central engine. The AGN-heated dust distributions turn out to be very compact with sizes on scales of about a parsec in the mid-infrared. Only infrared interferometry currently provides the necessary angular resolution to directly study the physical properties of this dust. Size estimates for the dust distributions derived from interferometric observations can be used to construct a size--luminosity relation for the dust distributions. The large scatter about this relation suggests significant differences between the dust tori in the individual galaxies, even for nuclei of the same class of objects and with similar luminosities. This questions the simple picture of the same dusty doughnut in all AGN. The Circinus galaxy is the closest Seyfert 2 galaxy. Because its mid-infrared emission is well resolved interferometrically, it is a prime target for detailed studies of its nuclear dust distribution. An extensive new interferometric data set was obtained for this galaxy. It shows that the dust emission comes from a very dense, disk-like structure which is surrounded by a geometrically thick, similarly warm dust distribution as well as significant amounts of warm dust within the ionisation cone.Comment: 8 pages, 3 figures, to appear in the proceedings of the conference "The central kiloparsec in Galactic Nuclei: Astronomy at High Angular Resolution 2011", open access Journal of Physics: Conference Series (JPCS), published by IOP Publishin