Clinical management of a peri-implant giant cell granuloma

Purpose. Implant therapy plays an important role in contemporary dentistry with high rates of long-term success. However, in recent years, the incidence of peri-implantitis and implant failures has significantly increased. The peripheral giant cell granuloma (PGCG) rarely occurs in peri-implant tissues and it is clinically comparable to the lesions associated with natural teeth. Therefore, the study of possible diseases associated with dental implants plays an important role in order to be able to diagnose and treat these conditions. Materials and Methods. This report described a 60-year-old Caucasian male who presented a reddish-purple pedunculated mass, of about 2 cm in diameter, associated with a dental implant and the adjacent natural tooth. Results. An excisional biopsy was performed and the dental implant was not removed. Histological examination provided the diagnosis of PGCG. After 19-month follow-up, there were no signs of recurrence of peri-implantitis around the implant. Conclusion. The correct diagnosis and appropriate surgical treatment of peri-implant giant cell granuloma are very important for a proper management of the lesion in order to preserve the implant prosthetic rehabilitation and prevent recurrences

Asymmetry at LHC for an U(1)' anomalous extension of MSSM

The measurement of the forward-backward asymmetry at LHC could be an important instrument to pinpoint the features of extra neutral gauge particles obtained by an extension of the gauge symmetry group of the standard model. For definitiveness, in this work we consider an extension of the gauge group of the Minimal Supersymmetric Standard Model by an extra anomalous U(1) gauge symmetry (MiAUMSSM). We focus on pp -> e+e- at LHC and use four different definitions of the asymmetry obtained implementing four different cuts on the directions and momenta of the final states of our process of interest. The calculations are performed without imposing constraints on the charges of the extra Z's of our model, since the anomaly is cancelled by a Green-Schwarz type mechanism. Our final result is a fit of our data with a polynomial in the charges from which to extract the values of the charges given the experimental result.Comment: 10 pages, 12 figure

Potential use of human periapical cyst-mesenchymal stem cells (hPCy-MSCs) as a novel stem cell source for regenerative medicine applications

Mesenchymal stem cells (MSCs) are attracting growing interest by the scientific community due to their huge regenerative potential. Thus, the plasticity of MSCs strongly suggests the utilization of these cells for regenerative medicine applications. The main issue about the clinical use of MSCs is related to the complex way to obtain them from healthy tissues; this topic has encouraged scientists to search for novel and more advantageous sources of these cells in easily accessible tissues. The oral cavity hosts several cell populations expressing mesenchymal stem cell like-features, furthermore, the access to oral and dental tissues is simple and isolation of cells is very efficient. Thus, oral-derived stem cells are highly attractive for clinical purposes. In this context, human periapical cyst mesenchymal stem cells (hPCy-MSCs) exhibit characteristics similar to other dental-derived MSCs, including their extensive proliferative potential, cell surface marker profile and the ability to differentiate into various cell types such as osteoblasts, adipocytes and neurons. Importantly, hPCy-MSCs are easily collected from the surgically removed periapical cysts; this reusing of biological waste guarantees a smart source of stem cells without any impact on the surrounding healthy tissues. In this review, we report the most interesting research topics related to hPCy-MSCs with a newsworthy discussion about the future insights. This newly discovered cell population exhibits interesting and valuable potentialities that could be of high impact in the future regenerative medicine applications

Childhood overweight-obesity and periodontal diseases: is there a real correlation?

Objective. The association between obesity and periodontitis has been extensively investigated in adults but not in young people. The aim of this study was to examine the association between overweight-obesity and periodontal disease in pediatric subjects. Methods. Controlled cross-sectional study involving 100 school children of both gender (50 M and 50 F) between 7 and 12 years of age (mean age 9,19 +/- 1,57). Two groups were formed based on Body Mass Index value: test group with BMI >= 25 Kg/m(2) and control group with BMI <= 24 Kg/m(2). Diet intake and oral hygiene habits were recorded by a specific questionnaire and the periodontal clinical parameters were evaluated. Results. The periodontal examination in the control group revealed a full-mouth plaque score (FMPS) value equal to 21.86% against 50.08% in the group of patients overweight/obese; the full-mouth bleeding score (FMBS) in the control group amounted to 12.7% against 26.24% of test group. No patient in either group included in the study presented a probing pocket depth (PPD) >= 3, so a significant difference regarding this value was not found. Regarding the frequency and quantity of food consumption, the number of obese patients who did not follow a balanced diet largely exceeded the number of normal-weight patients (70 versus 20%). Conclusions. These results focus the attention on the negative impact of obesity on gingival health in young subjects, probably due to a combination of metabolic and inflammatory profiles and the result of a careless attitude towards prevention diseases of the oral cavit

Use of dermal-fat grafts in the post-oncological reconstructive surgery of atrophies in the zygomatic region: clinical evaluations in the patients undergone to previous radiation therapy

INTRODUCTION: Grafting of autologous adipose tissue can be recommended in some cases of facial plastic surgery. Rhabdomyosarcoma is a type of cancer that can also affect the orbit. Enucleation of the eye can cause atrophy of the corresponding hemiface and decreased orbital growth. CASE REPORT: We report a case of a female patient with a medical history of surgical enucleation of the right eyeball, who had received rhabdomyosarcoma radiation therapy in her youth. The patient presented with a depression in the right zygomatic region. We took a dermal-fat flap from the abdominal region, which had been previously treated. RESULTS: The surgical outcome, 48 hours, and much clearly 31 days after the surgery, revealed that the right zygomatic region had returned to its proper anatomical shape, although there were still signs of postoperative edema. DISCUSSION: Very damaged tissues, like those exposed to radiation therapy, are generally not suitable for grafting of adipose tissue. CONCLUSIONS: In the described case, we achieved a technically and aesthetically satisfying result despite the patient's medical history involving several perplexities about the use of autologous dermal-fat tissues, because of prior radiation therapy exposure. The clinical case shows that even a region exposed to radiation therapy can be a valid receiving bed for dermal-fat grafting

HST survey of the Orion Nebula Cluster in the H2_2O 1.4 μ\mum absorption band: I. A census of substellar and planetary mass objects

In order to obtain a complete census of the stellar and sub-stellar population, down to a few M$_{Jup}$ in the $\sim1$ Myr old Orion Nebula Cluster, we used the infrared channel of the Wide Field Camera 3 of the Hubble Space Telescope with the F139M and F130N filters. These bandpasses correspond to the $1.4 \mu$m H$_2$O absorption feature and an adjacent line-free continuum region. Out of $4,504$ detected sources, $3,352$ (about $75\%$) appear fainter than m$_{130}=14$ (Vega mag) in the F130N filter, a brightness corresponding to the hydrogen-burning limit mass (M$\simeq 0.072 M_\odot$) at $\sim 1$ Myr. Of these, however, only $742$ sources have a negative F130M-139N color index, indicative of the presence of H$_2$O vapor in absorption, and can therefore be classified as bona-fide M and L dwarfs, with effective temperatures T$\lesssim 2850$ K at an assumed $1$ Myr cluster age. On our color-magnitude diagram, this population of sources with H$_2$O absorption appears clearly distinct from the larger background population of highly reddened stars and galaxies with positive F130M-F139N color index, and can be traced down to the sensitivity limit of our survey, m$_{130}\simeq 21.5$, corresponding to a $1$ Myr old $\simeq 3$M$_{Jup}$, planetary mass object under about 2 magnitudes of visual extinction. Theoretical models of the BT-Settl family predicting substellar isochrones of $1, 2$ and $3$ Myr (down to $\sim 1$M$_{Jup}$) fail to reproduce the observed H$_2$O color index at M$\lesssim 20$M$_{Jup}$. We perform a Bayesian analysis to determine extinction, mass and effective temperature of each sub-stellar member of our sample, together with its membership probability.Comment: Accepted for publication in the Astrophysical Journal. The resolution of several figures has been downgraded to comply with the size limit of arXiv submission

On a Stackelberg Subset Sum Game

This contribution deals with a two-level discrete decision problem, a so-called Stackelberg strategic game: A Subset Sum setting is addressed with a set $N$ of items with given integer weights. One distinguished player, the leader, may alter the weights of the items in a given subset $L\subset N$, and a second player, the follower, selects a solution $A\subseteq N$ in order to utilize a bounded resource in the best possible way. Finally, the leader receives a payoff from those items of its subset $L$ that were included in the overall solution $A$, chosen by the follower. We assume that the follower applies a publicly known, simple, heuristic algorithm to determine its solution set, which avoids having to solve NP-hard problems. Two variants of the problem are considered, depending on whether the leader is able to control (i.e., change) the weights of its items (i) in the objective function or (ii) in the bounded resource constraint. The leader's objective is the maximization of the overall weight reduction, for the first variant, or the maximization of the weight increase for the latter one. In both variants there is a trade-off for each item between the contribution value to the leader's objective and the chance of being included in the follower's solution set. We analyze the leader's pricing problem for a natural greedy strategy of the follower and discuss the complexity of the corresponding problems. We show that setting the optimal weight values for the leader is, in general, NP-hard. It is even NP-hard to provide a solution within a constant factor of the best possible solution. Exact algorithms, based on dynamic programming and running in pseudopolynomial time, are provided. The additional cases, in which the follower faces a continuous (linear relaxation) version of the above problems, are shown to be straightforward to solve.Comment: 13 pages, 1 figur