Supplementary Material for Procognitive Compounds Promote Neurite Outgrowth

<strong><em>Background/Aims:</em></strong> To this date, the only available drugs for treating Alzheimer's disease are cognitive enhancers, which may improve the cognitive function of patients for a few years while the disease continues to progress. As such, there are intense investigations to develop disease-modifying drugs to suppress progressive neurodegeneration. <b><i>Methods:</i></b> In this study, a range of procognitive compounds are tested in a primary neuronal culture to determine their relative potential for promoting neuritogenesis. <b><i>Results:</i></b> We report that donepezil, memantine, dimebon, Pre-084 and 4-IBP are neuritogenic while tacrine, rosemarinic acid, memoquin and a BACE1 inhibitor suppress neurite outgrowth of neurons. <b><i>Conclusions:</i></b> The results of this study indicate that some procognitive compounds may possess a disease-modifying potential

AEgIS experiment: Status & outlook

The AEGIS experiment1 (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) is planned to perform the first measurement of the gravitational acceleration on antimatter by observing the free fall of antihydrogen atoms. By combining techniques based on recent developments in the production of positronium and its laser excitation to Rydberg states, such a study seems indeed to be feasible for neutral antimatter. We present here some of the experimental techniques involved in the experiment as well as the status of the detector test envisioned for the gravity measurement

AEgIS experiment: Status & outlook

none63The AEGIS experiment1 (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) is planned to perform the first measurement of the gravitational acceleration on antimatter by observing the free fall of antihydrogen atoms. By combining techniques based on recent developments in the production of positronium and its laser excitation to Rydberg states, such a study seems indeed to be feasible for neutral antimatter. We present here some of the experimental techniques involved in the experiment as well as the status of the detector test envisioned for the gravity measurement.noneLansonneur P.; Aghion S.; Amsler C.; Bonomi G.; Brusa R.S.; Caccia M.; Caravita R.; Castelli F.; Cerchiari G.; Comparat D.; Consolati G.; Demetrio A.; Di Noto L.; Doser M.; Evans C.; Ferragut R.; Fesel J.; Fontana A.; Gerber S.; Giammarchi M.; Gligorova A.; Guatieri F.; Haider S.; Hinterberger A.; Holmestad H.; Kellerbauer A.; Khalidova O.; Krasnicky D.; Lagomarsino V.; Lebrun P.; Malbrunot C.; Mariazzi S.; Marton J.; Matveev V.; Mazzotta Z.; Muller S.R.; Nebbia G.; Nedelec P.; Oberthaler M.; Pacico N.; Pagano D.; Penasa L.; Petracek V.; Prelz F.; Prevedelli M.; Ravelli L.; Rienaecker B.; Robert J.; Rhone O.M.; Rotondi A.; Sacerdoti M.; Sandaker H.; Santoro R.; Simon M.; Smestad L.; Sorrentino F.; Testera G.; Tietje I.C.; Widmann E.; Yzombard P.; Zimmer C.; Zmeska J.; Zurlo N.Lansonneur, P.; Aghion, S.; Amsler, C.; Bonomi, G.; Brusa, R. S.; Caccia, M.; Caravita, R.; Castelli, F.; Cerchiari, G.; Comparat, D.; Consolati, G.; Demetrio, A.; Di Noto, L.; Doser, M.; Evans, C.; Ferragut, R.; Fesel, J.; Fontana, A.; Gerber, S.; Giammarchi, M.; Gligorova, A.; Guatieri, F.; Haider, S.; Hinterberger, A.; Holmestad, H.; Kellerbauer, A.; Khalidova, O.; Krasnicky, D.; Lagomarsino, V.; Lebrun, P.; Malbrunot, C.; Mariazzi, S.; Marton, J.; Matveev, V.; Mazzotta, Z.; Muller, S. R.; Nebbia, G.; Nedelec, P.; Oberthaler, M.; Pacico, N.; Pagano, D.; Penasa, L.; Petracek, V.; Prelz, F.; Prevedelli, M.; Ravelli, L.; Rienaecker, B.; Robert, J.; Rhone, O. M.; Rotondi, A.; Sacerdoti, M.; Sandaker, H.; Santoro, R.; Simon, M.; Smestad, L.; Sorrentino, F.; Testera, G.; Tietje, I. C.; Widmann, E.; Yzombard, P.; Zimmer, C.; Zmeska, J.; Zurlo, N