Attenuation Of Hypertension, Cardiomyocyte Hypertrophy, And Myocardial Fibrosis By Beta-adrenoceptor Blockers In Rats Under Long-term Blockade Of Nitric Oxide Synthesis.

The effects of propranolol and atenolol were investigated on arterial hypertension, cardiomyocyte hypertrophy, and ventricular ischaemic lesions induced by an 8-week treatment with the nitric oxide synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 20 mg/rat per day) in Wistar rats. Propranolol and atenolol (30 mg/rat per day each) were given in the drinking water concomitantly to L-NAME. Treatment with L-NAME induced marked arterial hypertension and cardiomyocyte hypertrophy, both of which were significantly reduced by propranolol and atenolol. A marked repairing fibrosis was also observed in L-NAME-treated rats and this was significantly attenuated in animals receiving the beta-blockers. In L-NAME group, 33% mortality was observed, whereas all the animals from the other groups survived. Our study demonstrates that propranolol and atenolol reduce arterial hypertension, cardiomyocyte hypertrophy and myocardial fibrosis induced by L-NAME, suggesting that beta-blockers are of beneficial value in treatment of vascular and cardiac alterations caused by chronic nitric oxide deficiency.39201-

As ações do núcleo de monitoramento de penas alternativas no município de Londrina

This article intends to present the “Nucleus of Management of Alternative Punishments of Londrina”, whore aim is to offer a multidisciplinary work of attention and attendance to drugs users sanctioned by de article 28, law 11.343/06. Therefore, the text brings some considerations about alternative punishments, the new drugs law, and an analysis about the thematic associated with the field of action of the project team. Furthermore, we present the “Núcleo” and the work developed there also the importance and the validity of congener initiatives, in order to concretize the reparatory potential of alternative punishment, continuing the developments of de law, and the attendance to the drugs users sanctioned.O presente artigo tem, por objetivo, apresentar o Núcleo de Monitoramento de Penas Alternativas de Londrina, cuja proposta é oferecer um trabalho multidisciplinar de atenção e de acompanhamento do processo de cumprimento da pena, aos usuários de drogas, sancionados nos termos do artigo 28, da Lei 11.343/06. Tendo isso em vista, o texto traz algumas considerações sobre as penas alternativas, a nova Lei de Drogas e analisa temáticas diretamente associadas ao campo específico de ação da Equipe do Projeto. Fazemos ainda uma apresentação do Núcleo e do trabalho desenvolvido, apresentando a importância e a validade de iniciativas congêneres, para a concretizar o potencial reinseridor das penas alternativas, para dar continuidade aos avanços empreendidos pela lei e ainda, para atender, de modo eficaz, aos usuários de drogas, sancionados