Tehnika životinja

Tehnika „životinja“ uobičajena je u praksi mnogih svjetskih dramskih škola, od Le Coqove L'École Internationale de Théâtre Jacques Lecoq do Strasbergove The Lee Strasberg Theatre & Film Institute. U posljednjih petnaestak godina poučava se i na Akademiji dramske umjetnosti u Zagrebu kao dio redovnog kurikuluma nastave Scenskog pokreta na 3.godini BA studija glume. Nakon sustavnog poučavanja tehnike životinja na ADU sve više mladih glumaca poseže za ovom tehnikom oplemenjivanja glumačkih procesa u radu na profesionalnim predstavama. Proces rada na „životinjama“ opisat ću iz vlastite perspektive kako bih osim predstavljanja tehnike iznio i probleme s kojima sam se suočio u nastavnom procesu

Tehnika životinja

Tehnika „životinja“ uobičajena je u praksi mnogih svjetskih dramskih škola, od Le Coqove L'École Internationale de Théâtre Jacques Lecoq do Strasbergove The Lee Strasberg Theatre & Film Institute. U posljednjih petnaestak godina poučava se i na Akademiji dramske umjetnosti u Zagrebu kao dio redovnog kurikuluma nastave Scenskog pokreta na 3.godini BA studija glume. Nakon sustavnog poučavanja tehnike životinja na ADU sve više mladih glumaca poseže za ovom tehnikom oplemenjivanja glumačkih procesa u radu na profesionalnim predstavama. Proces rada na „životinjama“ opisat ću iz vlastite perspektive kako bih osim predstavljanja tehnike iznio i probleme s kojima sam se suočio u nastavnom procesu

Varijante rješenja novog skladišta u zadanom prostoru

Cilj ovog rada je prikazivanje i razrada varijanti rješenja novog skladišnog sustava u unaprijed definiranom prostoru. Na samom početku opisan je problem preseljenja skladišta u nove prostore, zatim su dane teorijske osnove skladištenja i objašnjena je metoda projektiranja novog skladišnog sustava. Nastavak rada prati upravo tu metodu, pa je glavni dio rada posvećen analizi trenutnog skladišta i zaliha te izradi varijanti rješenja novog skladišnog sustava. Na koncu se pristupilo usporedbi varijanti i opisu mogućih metoda izbora varijanti

Analiza protoka vertikalnih podiznih modula

U ovom radu opisani su vertikalni podizni moduli. Nakon opisa područja tehničke logistike kojemu ovi uređaji pripadaju, prikazuju se detaljnije različite izvedbe, dijelovi, prednosti i nedostaci, te područja primjene. Glavni dio rada posvećen je modelima oblikovanja VLM-ova te se u radu analizira protok između dva različita tipa ovih sustava iz čega je na kraju donesen zaključak u kojim je to situacijama poželjno nabaviti VLM sa dva prozora za izuzimanje, a u kojim to i nema nekog smisla

The Effect of Cyclic Adenosine Monophosphate (cAMP) on Acute Liver Toxicity in Mice Induced by D-galactosamine and Lipopolysaccharide

The aim of this study was to examine the effect of cyclic adenosine monophosphate (cAMP) and its possible interference/synergism with calcium channel blocker in mice with acute liver injury induced with D-galactosamine (D-GalN) and lipopolysaccharide (LPS). C57Bl/6 mice were given i.p. simultaneously 300 mg/kg D-GalN and LPS 0.01 mg/kg. This treatment induced severe hepatitis, as evidenced by high mortality (80–90%) of control mice and large increase in concentration of aminotransferases in plasma (AST, ALT). Injection of stabile analogue of cAMP (dibutyryl-cAMP, db-cAMP) one hour before hepatotoxic agents increased survival of mice in dose-dependent manner and in medium dose significantly decreased plasma ALT level. Similar (protective) effect had also verapamil, calcium channel blocker, when given in non toxic doses and at the same time schedule as db-cAMP. Combination of db-cAMP and verapamil had not synergistic effect in protection from D-GalN+LPS hepatotoxicity; the survival of mice was similar to that seen in protection caused by each agent alone

Biomechanical stability analysis of transpedicular screws combined with sublaminar hook-rod system using the finite element method

Aim To develop and test a new posterior stabilization system by augmenting the posterior hook-rod system with screws and rods. Methods A biomechanical analysis was performed using the finite element method. The anatomical structures were modeled based on computed tomography data. Instrumentation (hooks, rods, and screws) was modeled based on the data obtained by 3D scanning. The discretized model was verified by converging solutions and validated against data from a previously published experiment. A Th12-L1 spinal segment was modeled and modified by removing the body of the L1 vertebra (corpectomy) and the entire L1 vertebra (spondylectomy). The model was additionally modified by incorporating stabilization systems: i) posterior stabilization (transpedicular screws and rods); ii) combined posterior stabilization with sublaminar hooks; and iii) combined anterior (titanium cage) and posterior (sublaminar hooks) stabilization. The rotation angles in each group, and the strains on each part of the three stabilization constructs, were analyzed separately. Results The combined anterior and posterior stabilization system was the stiffest, except in the case of lateral bending, where combined posterior stabilization was superior. Stress analysis showed that the posterior stabilization system was significantly unloaded when augmented with a hook-rod system. A significant strain concentration was calculated in the cranially placed hooks. Conclusion Stiffness analysis showed comparable stiffness between the tested and proposed stabilization construct. Stress analysis showed luxation tendency of the cranially placed hooks, which would most likely lead to system failure

Differences Between the Two Most Common Forms of Neurofibromatosis and the Importance of their Exact Diagnosis- a case report

Neurofibromatoza tipa 2 je rijetka genetska bolest s autosomno dominantnim tipom nasljeđivanja. Karakterizira je prisustvo mnogih tumora središnjeg živčanog sustava, među kojima su najčešći meningeomi i švanomi. Obilježje ove bolesti su bilateralni vestibulo- kohlearni švanomi. Iako postoje određene sličnosti s neurofibromatozom tipa 1, neurofibromatoza tipa 2 je uzrokovana potpuno drugačijom genetskom mutacijom, izaziva posebnu kliničku slike te se nadzire i liječi sasvim drugačije. Prikazujemo slučaj 17-godišnjeg dječaka koji je na početku kliničke obrade bio pogrešno dijagnosticiran kao slučaj neurofibromatoze tipa 1. Uziman- jem detaljnije anamneze i statusa pacijenta te daljnjom radiološkom obradom određena je ispravna dijagnoza neurofibromatoze tipa 2. Bolesnik je operiran 3 puta od strane iskusnih kirurga te je njegov slučaj temeljito diskutiran na pedijatrijskom onkološkom odboru. Neurofibromatoze postoje u raznim oblicima te se vode kao različite bolesti. Svaka dijagnoza neurofibromatoze treba biti postavljena korištenjem definiranih dijagnostičkih kriterija kako bi se omogućilo ispravno liječenje bolesnika te što dulje očuvanje njegove kvalitete života.Neurofibromatosis type 2 is a rare genetic disease with an autosomal dominant mode of transmission. It is characterized by many tumors in the central nervous system, where meningiomas and schwannomas are the most common. The hallmark of this disease is bilateral vestibulocochlear schwannomas. Although certain similarities with neurofibromatosis type 1 exist, neurofibromatosis type 2 is caused by a completely different gene mutation, producing a distinct clinical presentation and is monitored and treated differently. This paper will present the case of a 17-year-old boy misdiagnosed with neurofibromatosis type 1 at the beginning of his clinical workup. After taking a detailed patient history and an additional radiological examination, the correct diagnosis of neurofi- bromatosis type 2 was reached. The patient was operated on multiple times by experienced surgeons, which was thoroughly dis- cussed at the pediatric oncology board. Neurofibromatoses come in many forms and are different diseases. Every diagnosis of neu- rofibromatosis should be made using defined diagnostic criteria to enable the correct treatment of the patient and preserve the patient’s quality of life as much as possible

Bolesnik s adrenalnom insuficijencijom i pernicioznom anemijom: je li nova podjela autoimunog poliglandularnog sindroma primjerena?

A case of autoimmune polyglandular syndrome (APS) is presented. A 45-year-old man was admitted due to fatigue, malaise and inappetence. He had a history of primary hypothyroidism and was on levothyroxine substitution therapy. One year before, he was diagnosed with normocytic anemia and vitamin B12 deficiency, which was treated with vitamin B12 substitution therapy. Physical examination revealed hypotension and marked hyperpigmentation. Laboratory testing showed hyponatremia, hyperkaliemia and severe normocytic anemia. Endocrinological evaluation disclosed low morning cortisol and increased adrenocorticotropic hormone levels. Hence, the diagnosis of Addison’s disease was established. Additional laboratory workup showed positive parietal cell antibodies. However, his vitamin B12 levels were increased due to vitamin B12 supplementation therapy, which was initiated earlier. Gastroscopy and histopathology of gastric mucosa confirmed atrophic gastritis. Based on prior low serum vitamin B12 levels, positive parietal cell antibodies and atrophic gastritis, the patient was diagnosed with pernicious anemia. Hydrocortisone supplementation therapy was administered and titrated according to urinary-free cortisol levels. Electrolyte disbalance and red blood cell count were normalized. This case report demonstrates rather unique features of pernicious anemia in a patient with Addison’s disease. It also highlights the link between type II and type III APS. Not only do they share the same etiological factors, but also overlap in pathophysiological and clinical characteristics. This case report favors older classification of APS, which consolidates all endocrine and other organ-specific autoimmune diseases into one category. This is important since it might help avoid pitfalls in the diagnosis and treatment of patients with APS.Prikazujemo slučaj bolesnika s autoimunim poliglandularnim sindromom (APS). Muškarac u dobi od 45 godina hospitaliziran je zbog opće slabosti i malaksalosti. Od ranije je bolovao od primarne hipotireoze i uzimao je nadomjesnu terapiju levotiroksinom. Jednu godinu ranije otkrivena je normocitna anemija i deficit vitamina B12, zbog čega je liječen nadomjesnom terapijom vitaminom B12. Pri fizikalnom pregledu nađena je hipotenzija i naglašena hiperpigmentacija kože. Ulaboratorijskim nalazima nađena je hiponatremija, hiperkalemija i teška normocitna anemija. Endokrinološkom obradom nađen je snižen jutarnji kortizol te povišen ACTH, nakon čega je postavljena dijagnoza Addisonove bolesti. Dodatnom laboratorijskom obradom nađena su i pozitivna protutijela na parijetalne stanice uz povišenu koncentraciju vitamina B12 posljedično nadomjesnoj terapiji. Nalaz gastroskopije i patohistološke analize sluznice upućivao je na atrofični gastritis te je stoga postavljena dijagnoza perniciozne anemije. Započeta je nadomjesna terapija hidrokortizonom i titrirana prema ciljnim vrijednostima slobodnog kortizola u 24-satnoj mokraći. Elektrolitski disbalans i anemija su se normalizirali. Ovaj prikaz slučaja je opisao karakteristike perniciozne anemije u bolesnika s Addisonovom bolešću te naglašava vezu između APS tip II. i III. Ova dva sindroma dijele istu etiologiju te se njihove komponente često preklapaju. Slučaj našega bolesnika daje prednost starijoj klasifikaciji APS koja dopušta kombinacije svih primarnih endokrinih insufucijencija i drugih za organ specifičnih bolesti. Poštivajući staru podjelu APS mogu se izbjeći potencijalne zamke u dijagnostici i liječenju

Throughput analysis of vertical lift modules

U ovom radu opisani su vertikalni podizni moduli. Nakon opisa područja tehničke logistike kojemu ovi uređaji pripadaju, prikazuju se detaljnije različite izvedbe, dijelovi, prednosti i nedostaci, te područja primjene. Glavni dio rada posvećen je modelima oblikovanja VLM-ova te se u radu analizira protok između dva različita tipa ovih sustava iz čega je na kraju donesen zaključak u kojim je to situacijama poželjno nabaviti VLM sa dva prozora za izuzimanje, a u kojim to i nema nekog smisla.This paper describes the vertical lift modules. After describing the areas of technical logistics which these devices belongs to, more detailed are shown: versions, components, advantages and disadvantages, and applications. The main part of the paper presents throughput models for VLM. Then, throughputs are analyzed between two different types of these systems from which it was eventually adopted conclusions in which situations it is desirable to acquire VLM with two pick windows, and in which situations it does not make sense