Landscape Ecology of Sylvatic Chikungunya Virus and Mosquito Vectors in Southeastern Senegal

The risk of human infection with sylvatic chikungunya (CHIKV) virus was assessed in a focus of sylvatic arbovirus circulation in Senegal by investigating distribution and abundance of anthropophilic Aedes mosquitoes, as well as the abundance and distribution of CHIKV in these mosquitoes. A 1650 km2 area was classified into five land cover classes: forest, barren, savanna, agriculture and village. A total of 39,799 mosquitoes was sampled from all classes using human landing collections between June 2009 and January 2010. Mosquito diversity was extremely high, and overall vector abundance peaked at the start of the rainy season. CHIKV was detected in 42 mosquito pools. Our data suggest that Aedes furcifer, which occurred abundantly in all land cover classes and landed frequently on humans in villages outside of houses, is probably the major bridge vector responsible for the spillover of sylvatic CHIKV to humans

Cultural support workers and long day care services

In Australia, eligible long day care services may apply for support at the state level to assist with the transition of children from culturally or linguistically diverse backgrounds into childcare settings. For staff in childcare services, this support comes in the form of a cultural support worker (CSW). The primary role of a CSW is to build capacity in childcare staff to support children and families as they enter the childcare program. This paper draws on interview data and documentation from multiple sources to report the perspectives of key stakeholders affiliated with a cultural support program in an Australian childcare setting. It concludes that a more flexible approach to policy that directs the work of CSWs is needed, as well as further research into ways to build capacity for cultural competence for both CSWs and childcare staff who work collaboratively to support young children as they transition to childcare

Model-Based Systems Engineering and Through-Life Information Management in Complex Construction

Part 1: Building Information ModelingInternational audienceWith increasing maturity in model-based design and construction, a concomitant increase in the need for system-based methodologies and toolsets to support systems integration, requirements management, verification and validation and configuration management is evident if model-based information is to serve the operations of complex buildings and civil infrastructure projects. There is much to learn from best practices reported in complex discrete manufacturing. In particular, closed-loop product lifecycle management (PLM), systems engineering (SE) and model-based systems engineering (MBSE) are key to systems approaches to digital complex construction delivery and the reuse of model-based information for operations and maintenance (O&M). The paper reviews related research and investigates the role of the V-model in the development process, discussing its significance to structuring a through-life approach to information management. A discussion of Erasmus’ PLM aligned V-model is presented, and missing links in current BIM-enabled environments are identified relative to requirements engineering, verification and validation, and configuration management. The paper closes with a discussion of the gaps in supporting model-based tool ecologies and lack of a central structuring infrastructure, as well as the deficiencies in current process and data standards. Closing with the identification of a future research agenda

Interpretation in design: modelling how the situation changes during design activity

This paper presents a model of the way that designers move between situations when interpreting during design activity. Three hypotheses are presented that arise from this model: that designers change their situation during interpretation, that small changes in a source can lead to large changes in the representation, and that changes to the situation have their origins in the experience of the designer. The paper demonstrates how this internal movement between situations can be computationally implemented using three examples. The systems implemented demonstrate the way that interpretation can lead to changes in the situation and present an example of how the changes to a designer's situation can be guided by past experiences

Midbrain functional connectivity and ventral striatal dopamine D2-type receptors: link to impulsivity in methamphetamine users

Stimulant use disorders are associated with deficits in striatal dopamine receptor availability, abnormalities in mesocorticolimbic resting-state functional connectivity (RSFC), and impulsivity. In methamphetamine-dependent research participants, impulsivity is correlated negatively with striatal D2-type receptor availability, and mesocorticolimbic RSFC is stronger than in controls. The extent to which these features of methamphetamine dependence are interrelated, however, is unknown. This question was addressed in two studies. In Study 1, 19 methamphetamine-dependent and 26 healthy control subjects underwent [(18)F]fallypride positron emission tomography to measure ventral striatal dopamine D2-type receptor availability, indexed by binding potential (BP(ND)), and functional magnetic resonance imaging (fMRI) to assess mesocorticolimbic RSFC, using a midbrain seed. In Study 2, an independent sample of 20 methamphetamine-dependent and 18 control subjects completed the Barratt Impulsiveness Scale in addition to fMRI. Study 1 showed a significant group by ventral striatal BP(ND) interaction effect on RSFC, reflecting a negative relationship between ventral striatal BP(ND) and RSFC between midbrain and striatum, orbitofrontal cortex, and insula in methamphetamine-dependent participants but a positive relationship in the control group. In Study 2, an interaction of group with RSFC on impulsivity was observed. Methamphetamine-dependent participants users exhibited a positive relationship of midbrain RSFC to the left ventral striatum with cognitive impulsivity, whereas a negative relationship was observed in healthy controls. The results indicate that ventral striatal D2-type receptor signaling may affect system-level activity within the mesocorticolimbic system, providing a functional link that may help explain high impulsivity in methamphetamine-dependent individuals