Changing trends in mastitis

<p>Abstract</p> <p>The global dairy industry, the predominant pathogens causing mastitis, our understanding of mastitis pathogens and the host response to intramammary infection are changing rapidly. This paper aims to discuss changes in each of these aspects. Globalisation, energy demands, human population growth and climate change all affect the dairy industry. In many western countries, control programs for contagious mastitis have been in place for decades, resulting in a decrease in occurrence of <it>Streptococcus agalactiae </it>and <it>Staphylococcus aureus </it>mastitis and an increase in the relative impact of <it>Streptococcus uberis </it>and <it>Escherichia coli </it>mastitis. In some countries, <it>Klebsiella </it>spp. or <it>Streptococcus dysgalactiae </it>are appearing as important causes of mastitis. Differences between countries in legislation, veterinary and laboratory services and farmers' management practices affect the distribution and impact of mastitis pathogens. For pathogens that have traditionally been categorised as contagious, strain adaptation to human and bovine hosts has been recognised. For pathogens that are often categorised as environmental, strains causing transient and chronic infections are distinguished. The genetic basis underlying host adaptation and mechanisms of infection is being unravelled. Genomic information on pathogens and their hosts and improved knowledge of the host's innate and acquired immune responses to intramammary infections provide opportunities to expand our understanding of bovine mastitis. These developments will undoubtedly contribute to novel approaches to mastitis diagnostics and control.</p

Geostrophic and chimney regimes in rotating horizontal convection with imposed heat flux

Convection in a rotating rectangular basin with differential thermal forcing at one horizontal boundary is examined using laboratory experiments. The experiments have an imposed heat flux boundary condition, are at large values of the flux Rayleigh number ($Ra_{F}\sim O(10^{13}{-}10^{14})$ based on the box length $L$), use water with Prandtl number $Pr\approx 4$ and have a small depth to length aspect ratio. The results show the conditions for transition from non-rotating horizontal convection governed by an inertial–buoyancy balance in the thermal boundary layer, to circulation governed by geostrophic flow in the boundary layer. The geostrophic balance constrains mean flow and reduces the heat transport as Nusselt number $Nu\sim (Ra_{F}Ro)^{1/6}$, where $Ro=B^{1/2}/f^{3/2}L$ is the convective Rossby number, $B$ is the imposed buoyancy flux and $f$ is the Coriolis parameter. Thus flow in the geostrophic boundary layer regime is governed by the relative roles of horizontal convective accelerations and Coriolis accelerations, or buoyancy and rotation, in the boundary layer. Experimental evidence suggests that for more rapid rotation there is another transition to a regime in which the momentum budget is dominated by fluctuating vertical accelerations in a region of vortical plumes, which we refer to as a ‘chimney’ following related discussion of regions of deep convection in the ocean. Coupling of the chimney convection in the region of destabilising boundary flux to the diffusive boundary layer of horizontal convection in the region of stabilising boundary flux gives heat transport independent of rotation in this ‘inertial chimney’ regime, and the new scaling $Nu\sim Ra_{F}^{1/4}$. Scaling analysis predicts the transition conditions observed in the experiments, as well as a further ‘geostrophic chimney’ regime in which the vertical plumes are controlled by local geostrophy. When Ro<10^{-1}, the convection is also observed to produce a set of large basin-scale gyres at all depths in the time-averaged flow.</jats:p