18 research outputs found
Surface aggregation patterns of LDL receptors near coated pits III: potential effects of combined retrograde membrane flow-diffusion and a polarized-insertion mechanism
Towards screening Barrettâs Oesophagus: current guidelines, imaging modalities and future developments
Barrettâs oesophagus is the only known precursor to oesophageal adenocarcinoma (OAC). Although guidelines on the screening and surveillance exist in Barrettâs oesophagus, the current strategies are inadequate. Oesophagogastroduodenoscopy (OGD) is the gold standard method in screening for Barrettâs oesophagus. This invasive method is expensive with associated risks negating its use as a current screening tool for Barrettâs oesophagus. This review explores current definitions, epidemiology, biomarkers, surveillance, and screening in Barrettâs oesophagus. Imaging modalities applicable to this condition are discussed, in addition to future developments. There is an urgent need for an alternative non-invasive method of screening and/or surveillance which could be highly beneficial towards reducing waiting times, alleviating patient fears and reducing future costs in current healthcare services. Vibrational spectroscopy has been shown to be promising in categorising Barrettâs oesophagus through to high-grade dysplasia (HGD) and OAC. These techniques need further validation through multicentre trials
Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement.
Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of PM and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of PM within existing adult treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long-term therapeutic strategy. Endotype-driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment
Gender differences in the perception of asthma and respiratory symptoms in a population sample of asthma patients in four Brazilian cities
Differential epigenetic changes in the hippocampus and prefrontal cortex of female mice that had free access to cocaine
The risk of oesophageal adenocarcinoma in a prospectively recruited Barrettâs oesophagus cohort
Matching national forest policies and management practices for climate change adaptation in Burkina Faso and Ghana
Adaptation, Burkina Faso, Climate change, Forest ecosystems, Forest management practices, Forest policies, Ghana,