27 research outputs found

    Global nuts and local mangoes: a critical reading of the UNDP Growing Sustainable Business Initiative in Kenya

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    This article provides a conceptual and empirical assessment of UN brokered partnerships that seek to deepen or create inclusive and sustainable agricultural supply chains in sub-Saharan Africa. More specifically it appraises the decision-making mechanisms, processes of partnership brokerage and project implementation within the UNDP Growing Sustainable Business Initiative (GSB) in Kenya. The paper argues that the lack of bottom-up participation in decision-making mechanisms and the predominantly economic imperatives driving the GSB partnership projects have failed to reach out to the partnerships’ intended beneficiaries—Kenyan small producers of nuts and mangoes. In conclusion it is suggested that opening up the GSB platform might hold the promise of reconciling sustainable business models with (some) poverty reduction

    Critical perspectives on CSR and development: What we know, what we don't know, and what we need to know

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    The May 2005 issue of International Affairs addressed the theme of critical perspectives on Corporate Social Responsibility (CSR) in the developing world. The aim of this article is to take the debate a step further. Five researchers and practitioners on corporate social responsibility and development in various regions in the developing world - Central America, Pakistan, China, Vietnam, Argentina and India - using knowledge gained by their empirical research, argue that the management-oriented perspective on CSR and development is one-sided. While recognizing that critical approaches to the question have emerged, there is still a need to know which issues should form part of a critical research agenda on CSR and development. In this article the authors seek to fill this gap in order to facilitate a more in-depth investigation of what CSR initiatives can or cannot achieve in relation to improving conditions of workers and communities in the global South. They suggest that a critical research agenda on CSR and development should encompass four areas: a) the relationship between business and poverty reduction; b) the impact of CSR initiatives; c) governance dimensions of CSR; and d) power and participation in CSR. Such an alternative critical approach focuses on society's most vulnerable groups and adopts a 'people-centred' perspective as a counterbalance to the dominant 'business case' perspective. The authors conclude that this has significant implications for CSR practice. © The Royal Institute of International Affairs 2006

    Endoglin regulates nitric oxide-dependent vasodilatation

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    23 p.-8 fig.Endoglin is a membrane glycoprotein that plays an important role in cardiovascular development and angiogenesis. We examined the role of endoglin in the control of vascular tone by measuring nitric oxide (NO)-dependent vasodilation in haploinsufficient mice (Eng(+/-)) and their Eng(+/+) littermates. The vasodilatory effect of acetylcholine, bradykinin, and sodium nitroprusside was assessed in anesthetized mice; in isolated, perfused hindlimbs; and in aortic rings. The substantial hypotensive and vasodilatory response induced by acetylcholine and bradykinin in Eng(+/+) was markedly reduced in Eng(+/-) mice. Both kinds of animals had similar responses to sodium nitroprusside, suggesting that the deficient vasodilatory effect is not due to a NO response impairment. Urinary and plasma concentrations of nitrites, a NO metabolite, were lower in Eng(+/-) than in Eng(+/+) mice. The levels of endothelial nitric oxide synthase (eNOS) in kidneys and femoral arteries were about half in Eng(+/-) than in Eng(+/+) mice and were also reduced in primary cultures of aortic endothelial cells from Eng(+/-) compared with those from Eng(+/+) mice. Furthermore, overexpression or suppression of endoglin in cultured cells induced a marked increase or decrease in the protein levels of eNOS, respectively. Thus, our results in vivo and in vitro demonstrate a relationship between endoglin and NO-dependent vasodilation mediated by the regulation of eNOS expression.This study was supported by grants from Comisión Interministerial de Ciencia y Tecnología(SAF2001/1701 to J. M. López-Novoa and SAF2000-0132 to C. Bernabéu); Comunidad Autónoma de Madrid (to C. Bernabéu); and Fondo de Investigación Sanitaria (PI020200 to C.Bernabéu). Dr. M. Jerkic is supported by a Visiting Professor Tenure of the Spanish Ministerio de Ciencia y Tecnología.Peer reviewe
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