Labour politics and society in South Yorkshire.

This doctoral thesis looks at Labour politics and society in South Yorkshire between the start of the Second World War in September 1939 and the fall from office of the Attlee Labour Government in October 1951. While it accepts the predominating effects of national and international factors in providing challenges which Labour councils and local Labour Parties had to find solutions to - such as the effects of the Sheffield Blitz in 1940 and the need to re-plan Sheffield and the maintaining of the organisational existence of Labour Parties during the Second World War - it nevertheless examines those 'micro-historical' factors which made for the local diversity of the party in South Yorkshire. It tries to create a holistic and rounded portrait of the local Labour movement based mainly on fragmentary archival and newspaper evidence and examines current historical debates for local relevance such as whether a post-war consensus actually existed, whether popular political attitudes were radical or conservative and, whether such popular attitudes favoured or disfavoured Labour. It also looks at Marxist debates over the concept of 'Labourism' and whether Labour was narrowly culturally determined or whether other factors were equally important. Chapter One introduces the thesis. Chapter Two examines the fears over the post-war industrial future of Sheffield which took place during the Second World War within the City Council and between it and organisations like the trade unions and the Chamber of Commerce. It also looks at City Council debates over the proposed post-war regionalisation of local government and how that was prevented by a united council. This shows that the centralising tendencies of the London government could be resisted by the peripheries and that such tendencies were not inevitable. Chapter Three examines town planning in Sheffield during the Second World War after the Blitz in December 1940 provided an opportunity to create a more modem, better planned and less ugly city. The planning process is examined and the secrecy of the City Council noted at a time when the country was fighting to defend an open and democratic society from the Nazis. Chapter Three also looks at the wartime context of the acute post-war housing crisis. Chapter Four looks at the wartime Labour Party in South Yorkshire, its ebb in membership prior to 1942 and its resurgence after that date ending with an examination of the 1945 General Election in Sheffield. Chapter Five looks at local government between 1945 and 1951, examining the factors which prevented the reform of the local structure of local government, the effect on Sheffield and Rotherham Councils of the nationalisation of electricity, gas and local authority hospitals, and the attempts to implement the Butler Education Act of 1944 in South Yorkshire. Chapter Six looks at the attempts to implement the 1945 Collie town plan for Sheffield and the reasons for the lack of progress as well as at the contrasting housing records of Sheffield and Rotherham Councils. It attempts to account for the latter's better record when compared with the former. Chapter Seven looks the ideology and cultural determinants of the Labour Party in South Yorkshire between 1945 and 1951. It also examines Labour organisation noting the essential role of women as unpaid voluntary labour and contrasting it with their limited entry to local political office. Finally it looks at and comments on the municipal and general election results in Sheffield of the Labour Party between 1945 and 1951. Chapter Eight provides a conclusion

Risk factors for "major" embolic events in hospitalized patients with infective endocarditis.

BACKGROUND: Infective endocarditis often is complicated by embolic events after hospital admission. Identifying patients at higher risk may improve the disease outcome. This study was aimed at identifying predictors of embolic risk among the clinical and laboratory data obtained on hospital admission in patients diagnosed as having definite infective endocarditis according to the Duke criteria. METHODS: Ninety-four patients were enrolled in a prospective study. The results of hematologic, echocardiographic, and microbiological investigations were analyzed, using statistical methods as appropriate. Multivariate analysis was applied to variables significantly associated with embolism in univariate analysis. RESULTS: Forty-six percent of patients had a major embolic complication after admission. No association was found between embolism and sex, site of infection, or microorganism involved. Patients with embolism were significantly younger, had larger vegetation, and showed a significantly higher level of serum C-reactive protein and lower albumin concentrations than those without embolism. Young age, larger vegetation size, and high levels of C-reactive protein were the independent variables associated with an increased incidence of embolic events in the multivariate logistic regression analysis. CONCLUSIONS: Our data indicate that patients with infective endocarditis with young age and/or with large vegetation and/or with high serum levels of C-reactive protein are at increased risk of major embolic complications during the in-hospital course of the disease

Serum insulin-like growth factor I evaluation as a useful tool for predicting the risk of developing hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a prospective study

BACKGROUND: Although experimental studies have demonstrated an important role of insulin-like growth factor I (IGF-I) in hepatocarcinogenesis, the clinical data about IGF-I in patients with hepatocellular carcinoma (HCC) are scarce and controversial. To the authors' knowledge, this is the first prospective study investigating the longitudinal correlation between modifications in serum IGF-I levels and the development of HCC in a cohort of patients with hepatitis C virus (HCV)-related cirrhosis. METHODS: One hundred fourteen consecutive patients with HCV-related Child Grade A cirrhosis were followed prospectively at the Second University of Naples for 56.4 +/- 12.0 months with ultrasound examinations of the liver and serum alpha-fetoprotein determination every 6 months. At each clinical evaluation, the severity of disease was graded according to the established Child-Pugh scoring system. Serum IGF-I levels were measured prospectively at the study entry and at least every 12 months throughout follow-up. RESULTS: Twenty patients (19.2%) developed HCC during follow-up. Eleven of these patients had persistent Child Grade A cirrhosis for the whole study, whereas the other 9 patients developed HCC after their cirrhosis progressed from Child Grade A to Grade B. In patients who remained free of HCC for the whole study, serum IGF-I concentrations did not modify significantly during follow-up. Conversely, in patients who developed HCC, IGF-I levels decreased significantly during follow-up (from 72.6 +/- 29.9 microg/L to 33.8 +/- 14.5 microg/L; P = 0.001). In these patients, the significant decrease occurred both in patients with persistent Child Grade A cirrhosis and in patients with cirrhosis that progressed from Child Grade A to Grade B. The reduction in IGF-I level preceded the diagnosis of HCC by 9.3 +/- 3.1 months. CONCLUSIONS: This prospective study demonstrates that, in patients with HCV-related cirrhosis, 1) the development of HCC is accompanied by a significant reduction of serum IGF-I levels independent of the grade of impairment of liver function; and 2) modification of the IGF-I level precedes the morphologic appearance of HCC, permitting a precocious diagnosis of the tumor