10 research outputs found
Treatment for postoperative infection of pathological femoral fracture after radiotherapy: two case reports and review of the literature
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Characterization of a second nuclear gene, AEP1, required for expression of the mitochondrial OLI1 gene in Saccharomyces cerevisiae
- Author
- A Novick
- A Tzagoloff
- AM Cigan
- APGM Loon van
- B Lang
- C Yanisch-Perron
- CG Poutre
- CJ Langford
- CJ Langford
- CL Dieckmann
- CL Dieckmann
- D Vollrath
- E Boy-Marcotte
- EM Southern
- F Sanger
- F Sherman
- G Rigaud
- GB Cox
- GF Sprague
- J Kyte
- J Messing
- J Sambrook
- JE Hill
- JL Bennetzen
- JP Chamberlain
- JR Broach
- JW Proudlock
- K Struhl
- LA Grivell
- M Murphy
- M Schulze
- MC Costanzo
- MC Costanzo
- MC Costanzo
- MJ Payne
- P Haffter
- PM Finnegan
- PP Pelissier
- RJ Rothstein
- RS Klebe
- RW Davis
- S Bowman
- SA Mayer
- SH Ackerman
- SH Ackerman
- SH Ackerman
- SH Ackerman
- TA Kunkel
- UK Laemmli
- Y Gavel
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila
- Author
- Altan-Bonnet N
- Armbruster K
- Bharti S
- Cinalli RM
- Donaldson JG
- East MP
- Foe VE
- Francisco F. Rodrigues
- Frescas D
- Frigerio G
- Frolov MV
- Furman C
- Gillingham AK
- Guo Y
- Holly RM
- Lecuit T
- Lecuit T
- Lee DM
- Lee DM
- Lee DM
- Lee DM
- Leventis PA
- Liu Y
- Lorente-Rodriguez A
- Lucocq JM
- Luo R
- Mavor LM
- Mazelova J
- Mazumdar A
- Min MK
- Misteli T
- Papanikou E
- Pelissier A
- Poon PP
- Rabouille C
- Randazzo PA
- Richard Fehon
- Rikhy R
- Ripoche J
- Ross EM
- Shao W
- Sisson JC
- Sisson JC
- Spang A
- Sullivan W
- Tony J. C. Harris
- Trieselmann N
- Vert JP
- Walker DL
- Wang J
- Wei Shao
- Weissgerber TL
- Zaal KJ
- Publication venue
- 'American Society for Cell Biology (ASCB)'
- Publication date
- Field of study
Syndapin promotes pseudocleavage furrow formation by actin organization in the syncytial Drosophila
- Author
- Afshar K
- Ahuja R
- Alsop GB
- Ang SF
- Aparna Sherlekar
- Barmchi MP
- Bezanilla M
- Bringmann H
- Britton JS
- Bubb MR
- Bubb MR
- Buchsbaum RJ
- Cabernard C
- Cao J
- Carlier MF
- Castrillon DH
- Collings D
- Coué M.
- Crest J
- Daniels BR
- de Kreuk B-J
- Denise Montell
- Dharmalingam E
- D’Avino PP
- D’Avino PP
- Edeling MA
- Fededa JP
- Field CM
- Field CM
- Figard L
- Foe VE
- Foe VE
- Foissner I
- Foissner I
- Franki N
- Frescas D
- Frost A
- Goddette DW
- Gregory SL
- Grevengoed EE
- Grosshans J
- Guillot C
- Haglund K
- Heng Y-W
- Holly RM
- Jaiswal R
- Kellogg DR
- Kim SK
- Kinoshita M
- Kostan J
- Kumar V
- Laporte D
- Lecuit T
- Lecuit T
- Liu J
- Liu S
- Maddox AS
- Mavrakis M
- Mavrakis M
- Mavrakis M
- Meitinger F
- Murthy K
- Oegema K
- Ou GS
- Pelissier A
- Piekny AJ
- Qualmann B
- Ramachandran P
- Ramesh P
- Rand MD
- Rao Y
- Renshaw MJ
- Richa Rikhy
- Rikhy R
- Roberts-Galbraith RH
- Roos J
- Schmidt K
- Schulman VK
- Schwintzer L
- Simpson F
- Sokac AM
- Sokac AM
- Stevenson V
- Takeda T
- Tanaka-Takiguchi Y
- Watanabe S
- Webb RL
- Willet AH
- Yan S
- Yoshida S
- Publication venue
- 'American Society for Cell Biology (ASCB)'
- Publication date
- Field of study
Mechanisms and Control of Protein Synthesis in Yeast Mitochondria
- Author
- A Barrientos
- A Barrientos
- A Fiori
- A Tzagoloff
- A Tzagoloff
- A Zambrano
- AM Myers
- BG Barrell
- BG Ooi
- CG Poutre
- CL Dieckmann
- CV Lowry
- D Stock
- DF Steele
- DL Marykwas
- DU Mick
- DU Mick
- E Decoster
- ER Weber
- F Cabral
- F Fontanesi
- F Fontanesi
- F Fontanesi
- F Fontanesi
- F Pierrel
- F Pierrel
- F Tavares-Carreon
- FA Wollman
- FG Nobrega
- G Faye
- G Rödel
- G Rödel
- G Rödel
- G Rödel
- G Schatz
- G Szyrach
- GM Manthey
- H Salle De La
- HM Dunstan
- HP Zassenhaus
- I KĂĽhl
- I Muroff
- IC Soto
- J Lazowska
- JA Mears
- JJ Mulero
- JJ Mulero
- JJ Mulero
- JY Chen
- K Hell
- K Kehrein
- K Krause
- KA Lipinski
- L Guarente
- L Jia
- L Jia
- L Sagan
- LS Folley
- M Li
- M Ott
- M Ott
- M Prestele
- M Rak
- M Rak
- M Rak
- M Shingu-Vazquez
- M Simon
- MA Islas-Osuna
- MC Costanzo
- MC Costanzo
- MC Costanzo
- ME Sanchirico
- MJ Hollingsworth
- MJ Payne
- MJ Payne
- ML Valencik
- MS Rodeheffer
- MW Gray
- N Bonnefoy
- N Camougrand
- NG Brown
- O Groudinsky
- O Khalimonchuk
- O Khalimonchuk
- P Borst
- P Haffter
- P Haffter
- P Pelissier
- PM Smith
- PP Muller
- S Dhawale
- S Gruschke
- S Gruschke
- S Gruschke
- S Naithani
- SH Ackerman
- SL Forsburg
- T Christianson
- T Keng
- TD Fox
- TD Fox
- TM Mittelmeier
- TP Ellis
- TP Ellis
- TW McMullin
- TW McMullin
- V Zara
- V Zara
- V Zara
- W Chen
- X Perez-Martinez
- X Perez-Martinez
- X Zeng
- X Zeng
- ZM Chrzanowska-Lightowlers
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Incidence of tuberculosis among HIV-infected patients receiving highly active antiretroviral therapy in Europe and North America
- Author
- Abbadessa V
- Abgrall S
- Abrescia N
- Acinapura R
- Alberici F
- Alessandrini A
- Alexander C
- Alioum A
- Allegre T
- Amoah E
- Angarano G
- Antinori A
- Antonucci G
- Antunes F
- Antunes F
- Arch J
- Arici C
- Arici C
- Arlet Suau E
- Arlotti M
- Arnaudo I
- Aronica E
- Arvieux C
- Aslan A
- Auperin I
- Aviano Ar
- Babes V
- Bacarelli A
- Back Nkt
- Bakker Meg
- Baldelli F
- Balestre E
- Ballardini G
- Ballinger J
- Balu R
- Banhegyi D
- Bannister W
- Bannister W
- Bansi L
- Barrios R
- Barton S
- Basilico C
- Battegay M
- Bazin C
- Becker S
- Beckerman R
- Beckthold B
- Bell Dr
- Benfield T
- Beniowski M
- Bentata M
- Berkhout B
- Bernard N
- Bernard N
- Bernasconi E
- Bertelli D
- Berthe H
- Beylot J
- Beylot J
- Bhagani S
- Bickel M
- Bickel M
- Billaud E
- Blaizeau Mj
- Blanc Pa
- Blanco P
- Blaxhult A
- Blaxhult A
- Blok Wl
- Bocquentin F
- Boel E
- Boibieux A
- Bonarek M
- Bonasso M
- Boni J
- Bonnal F
- Bonnet F
- Bonten Mjm
- Borghi R
- Borleffs Jcc
- Boron Kaczmarska A
- Borsa Lebas F
- Bos Jc
- Bottari G
- Boucher Cab
- Boue F
- Bouvet E
- Braitstein P
- Brandi A
- Braschi Mc
- Bravenboer B
- Breen R
- Breilh D
- Brettle R
- Bricaire F
- Brinkman K
- Bronsveld W
- Bruggeman Camva
- Brumme Z
- Bruno R
- Bruun J
- Bucher H
- Buiting Agm
- Burdick J
- Burgisser P
- Burke M
- Buy E
- Byrne P
- Cadeo Gp
- Cadranel J
- Caggese L
- Capobianchi Mr
- Caramello P
- Cargnel A
- Carlebach A
- Carletti F
- Carnevale G
- Caron F
- Carosi G
- Carroll A
- Cassola G
- Castelli P
- Castera L
- Catanzaro Pp
- Cattacin S
- Cauda R
- Caunegre L
- Cavassini M
- Cazorla C
- Ceccaldi J
- Chadapaud S
- Chaloner C
- Chambon D
- Chan K
- Chandemerle C
- Chaplinskas S
- Chene G
- Chene G
- Chentsova N
- Chiesi A
- Chigiotti S
- Chiodera F
- Chiodo F
- Chirianni A
- Chirianni A
- Cinelli R
- Cioppi A
- Citterio P
- Claas Hcj
- Claessen Fap
- Clauvel Jp
- Clewley G
- Clotet B
- Clotet B
- Clumeck N
- Clumeck N
- Coadou B
- Cohen Valensi R
- Colangeli V
- Colebunders R
- Colomba A
- Conejero J
- Contant M
- Coronado O
- Cosco L
- Costagliola D
- Cote H
- Cotte L
- Cozzi Lepri A
- Cozzi Lepri A
- Crickx B
- Cropley I
- Cuijpers T
- Cuthbertson Z
- Cuzin L
- D'Alessandro M
- D'Elia S
- Dabis F
- Dabis F
- Dabis F
- Dann L
- Danner Sa
- Dauer B
- Dauer B
- de Geest Sv
- de Groot R
- De La Taille C
- De Lalla F
- De Longis P
- De Luca A
- De Marco M
- de Marie S
- De Stefano C
- de Truchis P
- de Vries Tems
- De Wit S
- De Witte S
- de Wolf F
- Decazes Jm
- Decoin M
- Dejesus E
- Delfraissy Jf
- Delmont Jp
- Delveaux S
- den Hollander Jg
- Desplanque N
- Di Perri G
- Dianzani F
- Diemer M
- Dieterch D
- Dietrich M
- Doedens R
- Doerr Hw
- Doornum Gjj
- Driessen G
- Drinkwater T
- Dubs R
- Duiculescu D
- Dupon M
- Dupon M
- Dupon M
- Dupont C
- Duran A
- Dutronc H
- Duval X
- Duvivier C
- Ebo F
- Egger M
- Egger M
- Eglinger P
- Ellerbroek Pm
- Elzi L
- Enel P
- Erb P
- Esposito R
- Esposito R
- Esterni Jp
- Faller Jp
- Fantelli K
- Farbos S
- Fatkenheuer G
- Fatkenheuer G
- Fatkenheuer G
- Fernandez T
- Ferrand M
- Ferrara S
- Ferrari C
- Filandras A
- Filice G
- Finazzi R
- Fiorini C
- Fischer M
- Fisher M
- Flepp M
- Fleury H
- Fontana A
- Fournier S
- Fox Z
- Fraisse P
- Francioli P
- Francioli P
- Franck Pfh
- Fresard A
- Friis Moeller N
- Frissen Phj
- Furrer H
- Furrer H
- Fusco G
- Fusco J
- Fusco J
- Gabbuti A
- Galama Jmd
- Galinier A
- Galli A
- Garcia Benayas T
- Gargalianos P
- Gasiorowski J
- Gasnault J
- Gastaut Ja
- Gataric N
- Gatell J
- Gatell Jm
- Gaud C
- Gaudebout C
- Geelen Spm
- Geerlings Se
- Geller J
- Gellie P
- Gerard L
- Geretti Am
- Gerstoft J
- Ghinelli F
- Gill J
- Gill Mj
- Gilquin J
- Girard Pm
- Girardi E
- Gjorup I
- Godfried Mh
- Goebel Fd
- Gonzalez Lahoz J
- Goossens Vj
- Gorgievski M
- Goujard C
- Gourdon F
- Grabar S
- Grabar S
- Granet Brunello P
- Gregory B
- Grima P
- Grisorio B
- Groeneveld Php
- Grossi Pa
- Guiguet M
- Guillemi S
- Gumley H
- Gute P
- Guyon F
- Gyssens Ic
- Haberl A
- Haberl A
- Hannapier C
- Hansen Abe
- Harrigan
- Harris M
- Hartwig N
- Hassoun G
- Helm Eb
- Hemmer R
- Hendriks R
- Herson S
- Hillebrand Haverkort Me
- Hirani A
- Hirschel B
- Hirschel B
- Hoepelman Im
- Hogg R
- Hogg R
- Holloway J
- Honore P
- Horban A
- Horban A
- Iacomi F
- Ippolito G
- Irek C
- Irek R
- Ising T
- Ivens D
- Izzo Cm
- Jacqmin Gadda H
- Jani I
- Janossy G
- Jansz Af
- Jaspers Cajj
- Jeantils V
- Jennings B
- Jeurissen Fjf
- Jevtovic D
- Johnson A
- Johnson A
- Johnson Am
- Johnson B
- Johnson M
- Johnson Ma
- Jou A
- Joy R
- Jung C
- Junghans C
- Jurriaans S
- Justice A
- Justice A
- Juttmann Jr
- Kahan M
- Kaiser L
- Karabatsaki E
- Karlsson A
- Karpov I
- Katlama C
- Katlama C
- Katlama C
- Katzenstein T
- Kauffmann Rh
- Keuter M
- Khuong Ma
- Kind C
- Kinloch de Loes S
- Kirk O
- Kirk O
- Kjaer J
- Klauke S
- Klimkait T
- Klinieken Zwolle I
- Knecht G
- Knysz B
- Koger Elw
- Koopmans Pp
- Kootstra Gj
- Kosmidis J
- Kravchenko E
- Kroes Acm
- Kroon Fp
- Kuijpers Tw
- La Gala A
- Labarrere S
- Lackey P
- Lacoste D
- Lacoste D
- Ladisa N
- Lafarie S
- Laffeuillade A
- Lafon Me
- Lampe As
- Lampe F
- Lang Jm
- Lang Jm
- Lange Jma
- Lanoy E
- Lauper U
- Laurichesse H
- Lavignolle Aurillac V
- Lavignolle V
- Lawson Ayayi S
- Lazzarin A
- Lazzarin A
- Ledergerber B
- Ledergerber B
- Ledergerber B
- Ledergerber B
- Legrand Mft
- Leneman H
- Lennemann T
- Lennemann T
- Leon S
- Leoncini F
- Lepeu G
- Leport C
- Lepri Ac
- Lesprit P
- Levy A
- Lewden C
- Lichtner M
- Lichtner M
- Lievre L
- Lipman M
- Livrozet Jm
- Lo Caputo S
- Locher L
- Longy Boursier M
- Longy Boursier M
- Loso K
- Losso M
- Loste P
- Loveday C
- Loveday C
- Loveday C
- Lowe Sh
- Lucht F
- Lundgren J
- Lundgren J
- Lutz T
- Maayan S
- Machala L
- Madge S
- Maeland A
- Magnani G
- Mairuhu Ata
- Malvy D
- Malvy D
- Manconi PAOLO EMILIO
- Mancuso S
- Manegold C
- Mannazzu M
- Mansinho K
- Manzillo E
- Martin Carbonero L
- Martinelli C
- Mary Krause M
- Masquelier B
- Massip P
- Matez F
- Matheron S
- Matheron S
- May M
- May M
- May T
- Mayaud C
- Mazzotta F
- Mazzotta F
- Mechali D
- Meenhorst Pl
- Melchers Wjg
- Melzi S
- Mena M
- Menichetti F
- Mercey D
- Mercie P
- Mercie P
- Merli S
- Meynard Jl
- Meyohas Mc
- Meyohas Mc
- Michelet C
- Miesen Wmaj
- Minafra G
- Minardi C
- Minoli L
- Miro Jm
- Mocroft A
- Mocroft A
- Mocroft A
- Moioli Mc
- Mokras M
- Molina Jm
- Mollerup D
- Monforte Ad
- Monforte Ad
- Montaner J
- Montesarchio E
- Montessori V
- Montroni M
- Moreau J
- Moreau Jf
- Moreau Jf
- Moriat P
- Morlat P
- Moroni M
- Mortier E
- Mortier L
- Mosch M
- Most B
- Mularska E
- Mulcahy F
- Mulder Jw
- Muller A
- Muller A
- Mura Ms
- Murphy G
- Murphy M
- Mussini C
- Nappa S
- Narciso P
- Neau D
- Neau D
- Nellen Fjb
- Nezri M
- Nielsen J
- Niesters Mg
- Nisius G
- Nisius G
- Noto P
- Nouts C
- Nouwen Jl
- Novati S
- Ocho A
- Olsen Ch
- Opravil M
- Orani A
- Ormaasen V
- Orofino Gc
- Ortolani P
- Osterhaus Adme
- Paccaud F
- Pagano G
- Pajkrt D
- Palepu A
- Palmer G
- Palvarini L
- Panos G
- Pantaleo G
- Pastecchia C
- Pastore G
- Pauw W
- Pedersen C
- Pehrson P
- Pelissier L
- Pellegrin I
- Pellegrin Jl
- Pellegrin Jl
- Pellegrin Jl
- Perdios J
- Pereira E
- Perenboom Rm
- Perini P
- Perrin L
- Petrelli E
- Petrosillo N
- Peyramond D
- Pezzotti P
- Pezzotti P
- Phillips A
- Phillips A
- Phillips A
- Phillips A
- Phillips A
- Phillips E
- Phillips P
- Pialoux G
- Piazza M
- Picard Dahan C
- Picard O
- Pierone G
- Piffaretti Jc
- Piscopo R
- Pistonne T
- Pizzaferri P
- Podlevkareva D
- Pogany K
- Poggio A
- Poizot Martin I
- Polee M
- Poll B
- Pollack S
- Poort Yag
- Post F
- Potard V
- Pozzi M
- Pradier C
- Pradier C
- Pradinaud R
- Press N
- Prestileo T
- Prins Jm
- Prinz B
- Pristera R
- Prokopowicz D
- Pugliese P
- Puradiredja D
- Pusterla L
- Pynka M
- Rabaud C
- Raffanti S
- Raffi F
- Ragnaud Jm
- Ragnaud Jm
- Ragnaud Jm
- Raise E
- Rakhmanova A
- Rana R
- Ravaux I
- Read R
- Reiss P
- Reiss P
- Reiss P
- Reiss P
- Repetto D
- Resta F
- Retornaz F
- Reynes J
- Rezza G
- Richter C
- Rickenbach M
- Rietra Pjgm
- Rijkeboer A
- Rijnders Bja
- Rizzardini G
- Rizzo E
- Rockstroh J
- Rockstroh J
- Roos Jc
- Roozendaal Kj
- Rottmann C
- Rottmann C
- Roudiere L
- Rouveix E
- Rozenbaum W
- Rozsypal H
- Rudin C
- Ruggieri A
- Ruiz Jm
- Ruys Ta
- Sabin C
- Sabin C
- Sabin C
- Saiag P
- Saidi S
- Saint Marc T
- Salamon R
- Salmon Ceron D
- Salmon D
- Sambatakou H
- Sanchez Conde M
- Sankatsing S
- Santoro D
- Saracino A
- Savelkoul P
- Scalise G
- Scalzini A
- Scarsella A
- Scasso A
- Scerbo A
- Schattenkerk Jkme
- Scherpbier Hj
- Schippers Ef
- Schirm J
- Schmeisser N
- Schmeisser V
- Schmid P
- Schmidt R
- Schneider Mme
- Scholvinck Eh
- Schouten I
- Schreij G
- Schupbach J
- Schurink Cam
- Schutten M
- Scullard G
- Sedlacek D
- Sellier P
- Shah S
- Sicard D
- Sighinolfi L
- Simon A
- Skinhoj P
- Smith C
- Sobel A
- Sobesky M
- Soranzo Ml
- Soravia Dunand V
- Soriano V
- Soscia F
- Soubeyrand J
- Speck R
- Sprenger Hg
- Stanekova D
- Staszewski S
- Staszewski S
- Staszewski S
- Staub T
- Steingrover R
- Stellbrink Hj
- Stephan C
- Sterne J
- Sthoeger Z
- Storm H
- Streinu Cercel A
- Sturmer M
- Suter F
- Swaans Cam
- Swaden L
- Swanink Cma
- Sweeney J
- Tacconi L
- Tanis Aa
- Tassi S
- Tattevin P
- Taverne B
- Tchamgoue S
- Telenti A
- Telenti A
- ten Kate Rw
- ten Napel Chh
- ten Veen Jh
- Thibaut P
- Thiebaut R
- Thiebaut R
- Thomas M
- Tinca M
- Tirard Fleury V
- Tirelli U
- Tisne Dessus D
- Tissot Dupont H
- Tortay I
- Torti C
- Tositti G
- Toti M
- Touchard D
- Touraine Jl
- Trepo C
- Trkola A
- Trocha H
- Trotta Mp
- Tsintas R
- Tundo P
- Tural C
- Turner D
- Tyndall M
- Tyrer M
- Ursitti Ma
- Uwamaliya Nziyumvira B
- Valadas E
- van Agtmael Ma
- van Dam Ps
- van de Heul C
- van den Broek
- van der Berg J
- van der Ende Me
- van der Feltz M
- van der Meer Jtm
- van der Poll T
- van der Valk M
- van der Ven Ajam
- van Dissel Jt
- van Eeden A
- van Gorp Ecm
- van Houte Dpf
- van Kasteren Mee
- van Leth F
- van Leth Fc
- van Leusen R
- van Lunzen J
- van Twillert G
- van Vonderen M
- van Vonderen Mga
- van Vugt M
- van Zanten Ap
- van Zeijl H
- Vanhems P
- Vassilenko A
- Vatan R
- Vecchiet J
- Veenendaal D
- Veenstra J
- Vella S
- Verbon A
- Verdon R
- Vernazza P
- Vetter N
- Viard Jp
- Viard Jp
- Vigano P
- Vigevani Gm
- Viglietti R
- Viksna L
- Vilde Jl
- Vincenti A
- Vinogradova E
- Voigt K
- von Blomberg Bme
- von Hentig N
- Vriesendorp R
- Vrouenraets Sme
- Vullo V
- Wasmuth Jc
- Weber J
- Weber R
- Weber R
- Weel J
- Weigel Hm
- Weiss L
- Weller I
- Widal Ghlf
- Wiercinska Drapalo A
- Wit Fwmn
- Wohrmann A.
- Wolf T
- Wolfs Tfw
- Wood E
- Yasdanpanah Y
- Yasdanpanah Y
- Yeni P
- Yerly S
- Yip B
- Yip B
- Youle M
- Yust I
- Zaccarelli M
- Ziekenhuis S
- Zilmer K
- Publication venue
- Publication date
- 01/01/2005
- Field of study
Background. We obtained estimates of the incidence of tuberculosis (TB) among patients receiving HAART and identified determinants of the incidence. Methods. We analyzed the incidence of TB during the first 3 years after initiation of HAART among 17,142 treatment-naive, AIDS- free persons starting HAART who were enrolled in 12 cohorts from Europe and North America. We used univariable and multivariable Poisson regression models to identify factors associated with the incidence. Results. During the first 3 years (36,906 person-years), 173 patients developed TB (incidence, 4.69 cases per 1000 person-years). In multivariable analysis, the incidence rate was lower for men who have sex with men, compared with injection drug users (relative rate, 2.46; 95% confidence interval [CI], 1.51-4.01), heterosexuals (relative rate, 2.42; 95% CI, 1.64-3.59), those with other suspected modes of transmission (relative rate, 1.66; 95% CI, 0.91-3.06), and those with a higher CD4(+) count at the time of HAART initiation (relative rate per log(2) cells/mL, 0.87; 95% CI, 0.84-0.91). During 28,846 person-years of follow-up after the first 6 months of HAART, 88 patients developed TB (incidence, 3.1 cases per 1000 person-years of follow-up). In multivariable analyses, a low baseline CD4(+) count (relative rate per log(2) cells/mL, 0.89; 95% CI, 0.83-0.96), 6-month CD4(+) count (relative rate per log(2) cells/mL, 0.90; 95% CI, 0.81-0.99), and a 6-month HIV RNA level 1400 copies/mL (relative rate, 2.21; 95% CI, 1.33-3.67) were significantly associated with the risk of acquiring TB after 6 months of HAART. Conclusion. The level of immunodeficiency at which HAART is initiated and the response to HAART are important determinants of the risk of TB. However, this risk remains appreciable even among those with a good response to HAART, suggesting that other interventions may be needed to control the TB epidemic in the HIV-infected population
Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS-defining conditions are created equal.
- Author
- Abbadessa V
- Abgrall S
- Abrescia N
- Acinapura R
- Acosta EP
- AgustĂ C
- AgĂĽero F
- Alberici F
- Aldins P
- Alessandrini A
- Alexander C
- Alioum A
- Allegre T
- Allison JJ
- Alquézar A
- Amoah E
- Antinori A
- Antiretroviral Therapy Cohort Collaboration Mocroft A
- Antonucci G
- Antunes F
- Arch J
- Arici C
- Arlet Suau E
- Arlotti M
- Arvieux C
- Aslan A
- Auperin I
- Babacan E
- Back NK
- Bakker ME
- Baldelli F
- Balestre E
- Ballardini G
- Balu R
- Banhegyi D
- Bannister W
- Bansi L
- Barin F
- Barragan P
- Barrios R
- Barrufet P
- Barton S
- Basilico C
- Battegay M
- Bazin C
- Becker S
- Beckerman R
- Beckthold B
- Begovac J
- Beijnen JH
- Benfield T
- Beniowski M
- Benne CA
- Bentata M
- Berkhout B
- Bernard N
- Bernasconi E
- Bertelli D
- Berthé H
- Beylot J
- Bhagani S
- Bickel M
- Billaud E
- Blaizeau MJ
- Blanc PA
- Blanco JL
- Blanco P
- Blok WL
- Bocquentin F
- Boel E
- Boffi E
- Bogner J
- Boibieux A
- Bolao F
- Bonarek M
- Bonnal F
- Bonnet F
- Bonnet F
- Bonten MJ
- Booth C
- Borch A
- Borleffs JC
- Boron Kaczmarska A
- Borsa Lebas F
- Bottari G
- Boucher CA
- Bouvet E
- Boué F
- Braitstein P
- Branger J
- Braschi MC
- Bravenboer B
- Breen R
- Breilh D
- Brettle R
- Bricaire F
- Brinkman K
- Bronsveld W
- Bruggeman CA
- Brumme Z
- Bruno R
- Bruun J
- Bucher H
- Buiting AG
- Buonfrate D
- Burdick J
- Burger DM
- Burke M
- Burty C
- Buy E
- Buzunova S
- Byrne P
- Böni J
- BĂĽrgisser P
- Cabellos C
- Cabié A
- Cadranel J
- Caggese L
- Camanni G
- Capitan MC
- Capobianchi MR
- Caramello P
- Carlebach A
- Carletti F
- Carnevale G
- Caron F
- Carosi G
- Carroll A
- Casabona J
- Casabona J
- Cassola G
- Castelli P
- Castera L
- Cattacin S
- Caubet O
- Cauda R
- Caunègre L
- Cavassini M
- Cazorla C
- Ceccaldi J
- Cervantes M
- Chadapaud S
- Chaloner C
- Chambon D
- Chan K
- Chandemerle C
- Chang PW
- Chaplinskas S
- Chentsova N
- Chiesi A
- Chiodera F
- Chiodo F
- Chirianni A
- ChĂŞne G
- Ciardi M
- Cicconi P
- Cioppi A
- Cipriano C
- Claas HC
- Claessen FA
- Clauvel JP
- Clewley G
- Clotet B
- Cloud G
- Clumeck N
- Coadou B
- Cohen Valensi R
- Colangeli V
- Colebunders R
- Colette Kempf M
- Colomba A
- Conejero J
- Contant M
- Cosco L
- Costagliola D
- Cote H
- Cotte L
- Couzigou P
- Cozzi Lepri A
- Crickx B
- Cristini G
- Cuijpers T
- Cuthbertson Z
- Cuzin L
- D'Alessandro M
- d'Arminio Monforte A
- D'Arminio Monforte A
- Dabis F
- Danner SA
- de Groot R
- De La Taille C
- De Longis P
- De Luca A
- De Marco M
- De Stefano C
- De Truchis P
- de Vries TE
- De Wit S
- De Witte S
- de Wolf F
- Decazes JM
- Decoin M
- Degen O
- DeJesus E
- Delfraissy JF
- Delmont JP
- Delveaux S
- den Hollander JG
- Desplanque N
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- Dianzani F
- Diemer M
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- Doedens R
- Doerr HW
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- Goossens VJ
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- Hillebrand Haverkort ME
- Hirani A
- Hirsch H
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- Hoepelman IM
- Hogg R
- Hogg R
- Holkmann Olsen C
- Holloway J
- Honoré P
- Horban A
- Hugen PW
- Huitema AD
- Hösli I
- Iacomi F
- Ippolito G
- Irek C
- Irek R
- Ising T
- Izzo CM
- Jacqmin Gadda H
- Jacquemet N
- Janossy G
- Jansen CL
- Jansz AF
- Jaspers CA
- Jeantils V
- Jeurissen FJ
- Jevtovic D
- Johnson A
- Johnson AM
- Johnson B
- Johnson M
- Johnson MA
- Jose Amengual M
- Jou A
- Joy R
- Jung C
- Jurriaans S
- Justice A
- Justice A
- Juttman JR
- Kahlert C
- Kaiser L
- Karabatsaki E
- Karlsson A
- Karpov I
- Karrer U
- Katlama C
- Katzenstein T
- Kauffmann RH
- Keuter M
- Khaykin P
- Khuong MA
- Kind C
- Kinloch de Loes S
- Kirk O
- Kitahata M
- Kitahata M
- Kjaer J
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- Klimkait T
- Knecht G
- Knysz B
- Koopmans PP
- Kootstra GJ
- Kosmidis J
- Kostov K
- Kousignian I
- Kravchenko E
- Krentz H
- Kroes AC
- Kroon FP
- Kuijpers TW
- La Gala A
- Labarga P
- Labarrère S
- Labbett W
- Lackey P
- Lacoste D
- Ladisa N
- Lafarie S
- Laffeuillade A
- Lafon ME
- Lampe AS
- Lampe F
- Lang JM
- Lange JM
- Lanoy E
- Lascaux AS
- Launay O
- Laurichesse H
- Lavignolle Aurillac V
- Lawson Ayayi S
- Lazaro E
- Lazzari E
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- Lucht F
- Lundgren J
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- LĂłpez Dieguez M
- Maayan S
- Machala L
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- Maeland A
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- Mahamat A
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- Mancuso S
- Mannazzu M
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- Martinetti G
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- Mateo G
- Matheron S
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- Mazzotta F
- Mechali D
- Melchers WJ
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- Mercey D
- Mercié P
- Merli S
- Meynard JL
- Meyohas MC
- Michelet C
- Minardi C
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- Miranda C
- MirĂł JM
- Mitsura VM
- Mocroft A
- Moioli MC
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- Molina JM
- Montaner J
- Montesarchio E
- Montessori V
- Montoliu A
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- Moreau J
- Moreau JF
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- Moroni M
- Mortier E
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- Mudrikove T
- Mugavero MJ
- Mularska E
- Mulcahy F
- Mulder JW
- Mura MS
- Murillas J
- Murphy M
- Mussini C
- Mösch M
- MĂĽller A
- MĂĽller N
- Nadal D
- Nair D
- NAPPA SALVATORE
- Narciso P
- Navarro G
- Navarro M
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- Nebbia G
- Negredo E
- Nellen FJ
- Nezri M
- Nielsen J
- Niesters MG
- Nisius G
- Noto P
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- Nouwen JL
- Novati S
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- Oestergaard L
- Olmo M
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- Orani A
- Ormaasen V
- Orofino GC
- Ortega N
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- Osterhaus AD
- Paccaud F
- Pagano G
- Pajkrt D
- Palepu A
- Palmer G
- Palvarini L
- Panos G
- Pantaleo G
- Pariente Khayat A
- Pastecchia C
- Pastore G
- Pauw W
- Pavie J
- Pedersen C
- Pelissier L
- Pellegrin I
- Pellegrin JL
- Pellizzer G
- Penelo E
- Perdios J
- Perenboom RM
- Perini P
- Persson PO
- Peters L
- Petrelli E
- Petrosillo N
- Pettersson A
- Peyramond D
- Pezzotti P
- Peña C
- Phillips A
- Phillips E
- Phillips P
- Pialoux G
- Piano P
- Piazza M
- Picard Dahan C
- Picard O
- Pierone G
- Pilorgé F
- Piscopo R
- Pistonne T
- Pisu M.
- Pizzaferri P
- Podlekareva D
- Podzamczer D
- Poggio A
- Pogány K
- Poizot Martin I
- Poll B
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- Polée MB
- Poort YA
- Post F
- Potard V
- Pozzi M
- Pradier C
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- Prestileo T
- Prins JM
- Prinz B
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- Prokopowicz D
- Puchol E
- Puradiredja J
- Pusterla L
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- Read R
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- Reiss P
- Resta F
- Retornaz F
- Rey D
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- Ridolfo A
- Riera M
- Rietra PJ
- Rijkeboer A
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- Speck R
- Sprenger HG
- Staneková D
- Staszewski S
- Staszewski S
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- Steingrover R
- Stellbrink HJ
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- Sterne JA
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- StĂĽrmer M
- Suetnov O
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- Swanink CM
- Tacconi L
- Taffé P
- Tanis AA
- Tarr P
- Tassi S
- Tattevin P
- Taverne B
- Tchamgoué S
- Telenti A
- ten Kate RW
- ten Napel CH
- Thibaut P
- Thiercelin Legrand MF
- Thiébaut R
- Thomas M
- Tirelli U
- Tisne Dessus D
- Tissot Dupont H
- Torti C
- Toti M
- Touchard D
- Touraine JL
- Trepo C
- Trezzi M
- Trkola A
- Trocha H
- Trotta MP
- Tsintas R
- Tural C
- Turner D
- Tyndall M
- Tyrer M
- Ursitti MA
- Uwamaliya Nziyumvira B
- Valadas E
- Van Agtmael MA
- van Assen S
- Van Crevel R
- Van de Heul C
- van den Berk GE
- van den Broek PJ
- van der Berg J
- van der Ende ME
- van der Feltz M
- van der Flier M
- van der Geest S
- van der Meer JT
- van der Poll T
- van der Ven AJ
- van Dissel JT
- van Eeden A
- van Gorp EC
- van Houte D
- van Kan HJ
- van Kasteren ME
- van Leeuwen JT
- van Lunzen J
- van Sighem AI
- van Vonderen MG
- van Vugt M
- van Zanten AP
- van Zeijl JH
- Vanhems P
- Vassilenko A
- Vatan R
- Vecchiet J
- Veenendaal D
- Veenstra J
- Veldkamp A
- Verbon A
- Verdon R
- Vermeulen JN
- Vernazza P
- Vetter N
- Viallard JF
- Viard JP
- Viganò P
- Viget N
- Viglietti R
- VilarĂł J
- Vincenti A
- Vinogradova E
- Vlassi C
- von Blomberg BM
- von Hentig N
- Vriesendorp R
- Vrouenraets SM
- Vullo V
- Wagenaar J
- Warris A
- Weber J
- Weber R
- Weel J
- Weiss L
- Weller I
- Westfall AO
- Wiercinska Drapalo A
- Willig JH
- Winkel K
- Wit FW
- Wolfs TF
- Wood E
- Xylomenos G
- Yasdanpanah Y
- Yeni P
- Yerly S
- Yip B
- Youle M
- Yust I
- Zaaijer HL
- Zaccarelli M
- Zilmer K
- Publication venue
- Publication date
- 01/01/2009
- Field of study
Abstract
Background—The extent to which mortality differs following individual acquired
immunodeficiency syndrome (AIDS)–defining events (ADEs) has not been assessed among
patients initiating combination antiretroviral therapy.
Methods—We analyzed data from 31,620 patients with no prior ADEs who started combination
antiretroviral therapy. Cox proportional hazards models were used to estimate mortality hazard
ratios for each ADE that occurred in >50 patients, after stratification by cohort and adjustment for
sex, HIV transmission group, number of anti-retroviral drugs initiated, regimen, age, date of
starting combination antiretroviral therapy, and CD4+ cell count and HIV RNA load at initiation
of combination antiretroviral therapy. ADEs that occurred in <50 patients were grouped together
to form a “rare ADEs” category.
Results—During a median follow-up period of 43 months (interquartile range, 19–70 months),
2880 ADEs were diagnosed in 2262 patients; 1146 patients died. The most common ADEs were
esophageal candidiasis (in 360 patients), Pneumocystis jiroveci pneumonia (320 patients), and
Kaposi sarcoma (308 patients). The greatest mortality hazard ratio was associated with non-
Hodgkin’s lymphoma (hazard ratio, 17.59; 95% confidence interval, 13.84–22.35) and progressive
multifocal leukoencephalopathy (hazard ratio, 10.0; 95% confidence interval, 6.70–14.92). Three
groups of ADEs were identified on the basis of the ranked hazard ratios with bootstrapped
confidence intervals: severe (non-Hodgkin’s lymphoma and progressive multifocal
leukoencephalopathy [hazard ratio, 7.26; 95% confidence interval, 5.55–9.48]), moderate
(cryptococcosis, cerebral toxoplasmosis, AIDS dementia complex, disseminated Mycobacterium
avium complex, and rare ADEs [hazard ratio, 2.35; 95% confidence interval, 1.76–3.13]), and
mild (all other ADEs [hazard ratio, 1.47; 95% confidence interval, 1.08–2.00]).
Conclusions—In the combination antiretroviral therapy era, mortality rates subsequent to an
ADE depend on the specific diagnosis. The proposed classification of ADEs may be useful in
clinical end point trials, prognostic studies, and patient management
Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS-defining conditions are created equal
- Author
- Abbadessa V
- Abgrall S
- Abrescia N
- Acinapura R
- Acosta EP
- AgustĂ C
- AgĂĽero F
- Alberici F
- Aldins P
- Alessandrini A
- Alexander C
- Alioum A
- Allegre T
- Allison JJ
- Alquézar A
- Amoah E
- Antinori A
- Antiretroviral Therapy Cohort Collaboration
- Antonucci G
- Antunes F
- Arch J
- Arici C
- Arlet Suau E
- Arlotti M
- Arvieux C
- Aslan A
- Auperin I
- Babacan E
- Back NK
- Bakker ME
- Baldelli F
- Balestre E
- Ballardini G
- Balu R
- Banhegyi D
- Bannister W
- Bansi L
- Barin F
- Barragan P
- Barrios R
- Barrufet P
- Barton S
- Basilico C
- Battegay M
- Bazin C
- Becker S
- Beckerman R
- Beckthold B
- Begovac J
- Beijnen JH
- Benfield T
- Beniowski M
- Benne CA
- Bentata M
- Berkhout B
- Bernard N
- Bernasconi E
- Bertelli D
- Berthé H
- Beylot J
- Bhagani S
- Bickel M
- Billaud E
- Blaizeau MJ
- Blanc PA
- Blanco JL
- Blanco P
- Blok WL
- Bocquentin F
- Boel E
- Boffi E
- Bogner J
- Boibieux A
- Bolao F
- Bonarek M
- Bonnal F
- Bonnet F
- Bonnet F
- Bonten MJ
- Booth C
- Borch A
- Borleffs JC
- Boron Kaczmarska A
- Borsa Lebas F
- Bottari G
- Boucher CA
- Bouvet E
- Boué F
- Braitstein P
- Branger J
- Braschi MC
- Bravenboer B
- Breen R
- Breilh D
- Brettle R
- Bricaire F
- Brinkman K
- Bronsveld W
- Bruggeman CA
- Brumme Z
- Bruno R
- Bruun J
- Bucher H
- Buiting AG
- Buonfrate D
- Burdick J
- Burger DM
- Burke M
- Burty C
- Buy E
- Buzunova S
- Byrne P
- Böni J
- BĂĽrgisser P
- Cabellos C
- Cabié A
- Cadranel J
- Caggese L
- Camanni G
- Capitan MC
- Capobianchi MR
- Caramello P
- Carlebach A
- Carletti F
- Carnevale G
- Caron F
- Carosi G
- Carroll A
- Casabona J
- Cassola G
- Castelli P
- Castera L
- Cattacin S
- Caubet O
- Cauda R
- Caunègre L
- Cavassini M
- Cazorla C
- Ceccaldi J
- Cervantes M
- Chadapaud S
- Chaloner C
- Chambon D
- Chan K
- Chandemerle C
- Chang PW
- Chaplinskas S
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- Zaaijer HL
- Zaccarelli M
- Zilmer K
- Publication venue
- Publication date
- 01/01/2009
- Field of study
Abstract
Background—The extent to which mortality differs following individual acquired
immunodeficiency syndrome (AIDS)–defining events (ADEs) has not been assessed among
patients initiating combination antiretroviral therapy.
Methods—We analyzed data from 31,620 patients with no prior ADEs who started combination
antiretroviral therapy. Cox proportional hazards models were used to estimate mortality hazard
ratios for each ADE that occurred in >50 patients, after stratification by cohort and adjustment for
sex, HIV transmission group, number of anti-retroviral drugs initiated, regimen, age, date of
starting combination antiretroviral therapy, and CD4+ cell count and HIV RNA load at initiation
of combination antiretroviral therapy. ADEs that occurred in <50 patients were grouped together
to form a “rare ADEs” category.
Results—During a median follow-up period of 43 months (interquartile range, 19–70 months),
2880 ADEs were diagnosed in 2262 patients; 1146 patients died. The most common ADEs were
esophageal candidiasis (in 360 patients), Pneumocystis jiroveci pneumonia (320 patients), and
Kaposi sarcoma (308 patients). The greatest mortality hazard ratio was associated with non-
Hodgkin’s lymphoma (hazard ratio, 17.59; 95% confidence interval, 13.84–22.35) and progressive
multifocal leukoencephalopathy (hazard ratio, 10.0; 95% confidence interval, 6.70–14.92). Three
groups of ADEs were identified on the basis of the ranked hazard ratios with bootstrapped
confidence intervals: severe (non-Hodgkin’s lymphoma and progressive multifocal
leukoencephalopathy [hazard ratio, 7.26; 95% confidence interval, 5.55–9.48]), moderate
(cryptococcosis, cerebral toxoplasmosis, AIDS dementia complex, disseminated Mycobacterium
avium complex, and rare ADEs [hazard ratio, 2.35; 95% confidence interval, 1.76–3.13]), and
mild (all other ADEs [hazard ratio, 1.47; 95% confidence interval, 1.08–2.00]).
Conclusions—In the combination antiretroviral therapy era, mortality rates subsequent to an
ADE depend on the specific diagnosis. The proposed classification of ADEs may be useful in
clinical end point trials, prognostic studies, and patient management
Does short-term virologic failure translate to clinical events in antiretroviral-naĂŻve patients initiating antiretroviral therapy in clinical practice?
- Author
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- Abgral S
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- Amengual MJ
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- Antinori A
- Antiretroviral Therapy Cohort Collaboration (ART-CC)
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- van Kasteren ME
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- van Lunzen J
- van Sighem AI
- van Vonderen MG
- van Vugt M
- van Zanten AP
- van Zeijl JH
- Vance D
- Vanhems P
- Varshney M
- Vassilenko A
- Vatan R
- Vecchiet J
- Veenendaal D
- Veenstra J
- Veldkamp A
- Vella S
- Verbon A
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- Vincenti A
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- Vullo
- Vullo V
- Wagenaar J
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- Wiercinska-Drapalo A
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- Yasdanpanah Y
- Yeni P
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- Zaccarelli M
- Zaccarelli M
- Zhang W
- Zilmer K
- Zoncada A
- Publication venue
- Publication date
- 01/01/2008
- Field of study
Cardiovascular Activity
- Author
- A Baartscheer
- A Baartscheer
- A Baartscheer
- A Bachmann
- A Bauer
- A Bergdahl
- A Bezold von
- A Biedl
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- A Cavalié
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- A Chu
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- A Hislop
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- A Jarisch
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- A Rudolph
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- Wienen W Hauel N, van Meel JCA, Narr B, Ries U, Entzeroth M (1993) Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 110:245–252 Wong PC, Quan ML, Saye JAM, Bernard R, Crain EJ Jr, Nc- Call DE, Watson CA, Zaspel AM, Smith RD, Wexler RR, Timmermans PBMWM, Chiu AT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study