24 research outputs found
The proximate composition of three marine pelagic fish: blue whiting (Micromesistius poutassou), boarfish (Capros aper) and Atlantic herring (Clupea harengus)
peer reviewedThis study presents data from an in-depth proximate compositional analysis of three marine fish species: blue
whiting (Micromesistius poutassou), boarfish (Capros aper) and Atlantic herring (Clupea harengus). These fish
contained significant amounts of protein (16–17%), lipids (4–11%) and minerals (2–6% ash). The proteins, particularly
from boarfish, had close to optimum amino acid profiles for human and fish nutrition. They compared favourably
with other fish species in terms of total lipids and relative concentration of the omega-3 fatty acids docosahexaenoic
acid and eicosapentaenoic acid (11.8–13.3% and 5.9–8.1% in triacylglycerols [TG] and 24.6–35.4% and 5.8–12.0% in
phospholipids [PL]). Atlantic herring had the highest lipid content among the three fish and was found to contain
high levels of PL poly-unsaturated fatty acids, including omega-3 fatty acids. Minerals detected in the fish included
calcium (272–1,520 mg/100 g), phosphorus (363–789 mg/100 g), iron (1.07–2.83 mg/100 g), magnesium (40.70–62.10
mg/100 g), potassium (112.00–267.00 mg/100 g), selenium (0.04–0.06 mg/100 g), sodium (218.00–282.00 mg/100 g)
and zinc (1.29–5.57 mg/100 g). Boarfish had the highest ash fraction and also the highest levels of all the minerals,
except potassium. Atlantic herring had considerably lower mineral content compared with the other two species
and, levels detected were also lower than those reported in previously published studies. Heavy metals contents
were quantified, and levels were significantly below the maximum allowable limits for all elements except arsenic,
which ranged from 1.34 to 2.44 mg/kg in the three fish species. Data outlined here will be useful for guiding product
development. Future studies would benefit from considering catch season, sex and developmental stage of the fish
“I might not have cancer if you didn’t mention it”: a qualitative study on information needed by culturally diverse cancer survivors
mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway
Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension
International audiencePulmonary arterial hypertension (PAH) is a devastating life-threatening disorder characterized by elevated pulmonary vascular resistance leading to elevated pulmonary arterial pressures, right ventricular failure and ultimately death. Vascular endothelial cells mainly produce and secrete endothelin (ET-1) in vessels that lead to a potent and long-lasting vasoconstrictive effect in pulmonary arterial smooth muscle cells. Along with its strong vasoconstrictive action, ET-1 can promote smooth muscle cell proliferation. Thus, ET-1 blockers have attracted attention as an antihypertensive drug and the ET-1 signaling system has paved a new therapeutic avenue for the treatment of PAH. The present chapter outlines not only the current understanding of the pathogenic role played by ET-1 signaling systems in the pathogenesis of PH, but also on the clinical pharmacology of endothelin receptor antagonists (ERA) used in the treatment of PAH