17 research outputs found
Objetos virtuais de aprendizagem: contribuições para o processo de aprendizagem em saúde e enfermagem
Mysid crustaceans as standard models for the screening and testing of endocrine-disrupting chemicals
Author Posting. © Springer, 2007. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Ecotoxicology 16 (2007): 205-219, doi:10.1007/s10646-006-0122-0.Investigative efforts into the potential endocrine-disrupting effects of chemicals have mainly
concentrated on vertebrates, with significantly less attention paid to understanding potential
endocrine disruption in the invertebrates. Given that invertebrates account for at least 95% of all
known animal species and are critical to ecosystem structure and function, it remains essential to
close this gap in knowledge and research. The lack of progress regarding endocrine disruption in
invertebrates is still largely due to: (1) our ignorance of mode-of-action, physiological control, and
hormone structure and function in invertebrates; (2) lack of a standardized invertebrate assay; (3)
the irrelevance to most invertebrates of the proposed activity-based biological indicators for
endocrine disruptor exposure (androgen, estrogen and thyroid); (4) limited field studies. Past and
ongoing research efforts using the standard invertebrate toxicity test model, the mysid shrimp, have
aimed at addressing some of these issues. The present review serves as an update to a previous
publication on the use of mysid shrimp for the evaluation of endocrine disruptors (Verslycke et al.,
2004a). It summarizes recent investigative efforts that have significantly advanced our
understanding of invertebrate-specific endocrine toxicity, population modeling, field studies, and
transgeneration standard test development using the mysid model.Supported by a Fellowship of the Belgian American Educational Foundation