Management of a Fungal Perinephric Abscess (PNA): Dilemma Revisited

ABSTRACT Candida species can cause a wide variety of clinical syndromes, especially in immunocompromised and diabetic patients. Primary perirenal candidial abscess has been a rare reported entity. Here we report a rare case of primary PNA due to Candida species in an immunocompetent patient with diabetes mellitus and its minimal invasive management. Retrospective and prospective analysis of clinical, laboratory and radiological records along with continued follow up of patient was done. This patient was 48-year-old man, admitted with burning in micturition, right flank discomfort and low grade fever since 1 year. Abdominal ultrasound and computerized tomography were suggestive of a PNA of the right kidney. Candida species was isolated from sample obtained by C.T. guided needle aspiration. Culture of aspirate showed sensitivity to azoles. Systemic antifungal therapy based on culture report was started in form of oral drug. The patient responded well leading to resolution of lump and the fever. Appropriate timely treatment appears to be having a promising role in definitive therapy for renal and PNA due to Candida even in immunocompetent host with predisposing factors such as diabetes mellitus. This case highlights the fact that fungal infections should be included in the differential diagnosis of PNA in such patients

Enhanced UV photosensitivity from rapid thermal annealed vertically aligned ZnO nanowires

We report on the major improvement in UV photosensitivity and faster photoresponse from vertically aligned ZnO nanowires (NWs) by means of rapid thermal annealing (RTA). The ZnO NWs were grown by vapor-liquid-solid method and subsequently RTA treated at 700°C and 800°C for 120 s. The UV photosensitivity (photo-to-dark current ratio) is 4.5 × 103 for the as-grown NWs and after RTA treatment it is enhanced by a factor of five. The photocurrent (PC) spectra of the as-grown and RTA-treated NWs show a strong peak in the UV region and two other relatively weak peaks in the visible region. The photoresponse measurement shows a bi-exponential growth and bi-exponential decay of the PC from as-grown as well as RTA-treated ZnO NWs. The growth and decay time constants are reduced after the RTA treatment indicating a faster photoresponse. The dark current-voltage characteristics clearly show the presence of surface defects-related trap centers on the as-grown ZnO NWs and after RTA treatment it is significantly reduced. The RTA processing diminishes the surface defect-related trap centers and modifies the surface of the ZnO NWs, resulting in enhanced PC and faster photoresponse. These results demonstrated the effectiveness of RTA processing for achieving improved photosensitivity of ZnO NWs

Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population

<div><p>Genome-wide association studies (GWAS) have identified dozens of common genetic variants associated with risk of colorectal cancer (CRC). However, the majority of CRC heritability remains unclear. In order to discover low-frequency, high-risk CRC susceptibility variants in Swedish population, we genotyped 1 515 CRC patients enriched for familial cases, and 12 108 controls. Case/control association analysis suggested eight novel variants associated with CRC risk (OR 2.0–17.6, p-value < 2.0E-07), comprised of seven coding variants in genes <i>RAB11FIP5</i>, <i>POTEA</i>, <i>COL27A1</i>, <i>MUC5B</i>, <i>PSMA8</i>, <i>MYH7B</i>, and <i>PABPC1L</i> as well as one variant downstream of <i>NEU1</i> gene. We also confirmed 27 out of 30 risk variants previously reported from GWAS in CRC with a mixed European population background. This study identified rare, coding sequence variants associated with CRC risk through analysis in a relatively homogeneous population. The segregation data suggest a complex mode of inheritance in seemingly dominant pedigrees.</p></div

Composition change-driven texturing and doping in solution-processed SnSe thermoelectric thin films

The discovery of SnSe single crystals with record high thermoelectric efficiency along the b-axis has led to the search for ways to synthesize polycrystalline SnSe with similar efficiencies. However, due to weak texturing and difficulties in doping, such high thermoelectric efficiencies have not been realized in polycrystals or thin films. Here, we show that highly textured and hole doped SnSe thin films with thermoelectric power factors at the single crystal level can be prepared by solution process. Purification step in the synthetic process produced a SnSe-based chalcogenidometallate precursor, which decomposes to form the SnSe2 phase. We show that the strong textures of the thin films in the b???c plane originate from the transition of two dimensional SnSe2 to SnSe. This composition change-driven transition offers wide control over composition and doping of the thin films. Our optimum SnSe thin films exhibit a thermoelectric power factor of 4.27 ??W cm???1 K???2

Shaping and Structuring Supramolecular Gels

Supramolecular gels assemble via non-covalent interactions between low-molecular-weight gelators (LMWGs). The gels form a solid-like nanoscale network spanning a liquid-like continuous phase, translating molecular-scale information into materials performance. However, gels based on LMWGs are often difficult to manipulate, easily destroyed and have poor rheological performance. The recurring image of newly-discovered supramolecular gels is that of an inverted vial showing that the gel can support its own weight against gravity. Such images reflect the limitation that these gels simply fill the vessel in which they are made, with limited ability to be shaped. This property prevents supramolecular gels from having the same impact as polymer gels, despite greater synthetic tunability, reversibility and bio/environmental compatibility. In this Review, we evaluate strategies for imposing different shapes onto supramolecular gels and for patterning structures within them. We review fabrication methods including moulding, self-healing, 3D printing, photopatterning, diffusion and surface-mediated patterning. We discuss gelator chemistries amenable to each method, highlighting how a multi-component approach can aid shaping and structuring. Supramolecular gels with defined shapes, or patterned structures with precisely-controlled compositions, have the potential to intervene in applications such as tissue engineering and nanoscale electronics, as well as opening-up new technologies

Quantitative earthquake-like statistical properties of the flow of soft materials below yield stress

The flow behavior of soft materials below the yield stress can be rich and is not fully understood. Here, we report shear-stress-induced reorganization of three-dimensional solid-like soft materials formed by closely packed nematic domains of surfactant micelles and a repulsive Wigner glass formed by anisotropic clay nano-discs having ionic interactions. The creep response of both the systems below the yield stress results in angular velocity fluctuations of the shearing plate showing large temporal burst-like events that resemble seismic foreshocks-aftershocks data measuring the ground motion during earthquake avalanches. We find that the statistical properties of the quake events inside such a burst map on to the scaling relations for magnitude and frequency distribution of earthquakes, given by Gutenberg-Richter and Omori laws, and follow a power-law distribution of the inter-occurrence waiting time. In situ polarized optical microscopy reveals that during these events the system self-organizes to a much stronger solid-like state

Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin

Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the alpha helical N-terminus of VDAC and in the channel wall, as revealed by molecular docking, followed by mutational analysis. N-terminus mimicking peptide showed conformational changes in circular dichroism, upon curcumin treatment. We propose that the interaction of curcumin with amino acids in N-terminus and in channel wall fixes the alpha helix in closed conformation. This restricts its movement which is required for the opening of the channel. (C) 2014 Elsevier B.V. All rights reserved

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Not AvailablePlesiomonas shigelloides was isolated from diseased silver carp in Kolkata Wetland, West Bengal, India. It was associated with mortality of Silver Carp, Hypophthalmichthys molitrix, which is the most widely cultivable fish species in fresh water aquaculture. The P. shigelloides was identified based on the biochemical and molecular characterization and the pathogenicity was studied on H. molitrix. The 16S rRNA gene sequence of the present isolate (NCBI GenBank Accession Number- KX986915) revealed that, the isolate was 100% identical with P. shigelloides (NCBI GenBank Accession Number- MF100995). P. shigelloides killed 10–100% fish in experimental infection and the LD50 value was calculated as 1.3× 105CFU per fish with intraperitoneal injection. The challenged fish had subcutaneous haemorrhagic ulcers and reddening at injection sites, however there was no clinical sign observed in the gill. The histology of experimentally challenged H. molitrix showed the kidney alterations and exhibited shrinkage of epithelial cells in renal tubule and enlargement of glomerular cells.Liver showed focal accumulation of edematous fluid, necrosis and infiltration of heterophils indicative of bacterial infection. The pathology and pathogenesis studies of this pathogen in inland open waters like wetlands and lakes would help in management of the outbreak of disease in these aquatic ecosystems.Not Availabl