Water Quality Deterioration of Machna River due to Sewage Disposal, Betul,Madhya Pradesh, India

In this study the Physico-chemical characteristics of Sewage waste water joining into Machna River at Betul were studied. The parameters pH, Total dissolved solids, Total suspended solids, Dissolved oxygen, BOD, COD, Nitrate, Chloride were assessed. The values of these parameters were found in excessive amounts as prescribed by World Health Organisation (WHO), which indicate towards the deterioration of water quality of water body after the joining of inlets into the river. The study emphasizes on the detrimental impact caused by the sewage water on Machna River. Key words: Water pollution, pH, Dissolved oxygen, Alkalinity, Hardnes

Study of risk factors causing coronary heart disease among army personnel of the rank non-commissioned officers and below in the age group of 20-50 years and its association with prehypertension

Background: Coronary heart disease (CHD) is an acute public health problem both in developed and in developing countries, like India. Assessing the prevalence of CHD in the community is equivalent to assessing the tip of the iceberg. Hypertension is a major risk factor for CHD and hypertension disease prevalence tip of the iceberg in the community is much more obscure. Objective: The objective of the study was to carry out a cross-sectional study among serving Army personnel, comprising healthy non-commissioned officers and other rank personnel to successfully assess the risk factors for CHD and their association with prehypertension. Materials and Methods: Screening of risk factors for CHD among 200 randomly selected participants was carried out. Blood pressure, height, weight, serum total cholesterol, serum triglycerides, serum high-density lipoprotein (HDL), random blood sugar levels, and smoking status were the major risk factors screened. Results: Nearly 63% of Army personnel were found to be having blood pressure commensurate to the range of prehypertension. About 15% were detected to be overweight, 22% had hypercholesterolemia, 5.4% had impaired glucose tolerance (IGT), and 19.2% were current smokers. Higher age, body mass index, high serum triglycerides, low serum HDL, and IGT were found to be independently associated with increased prevalence of prehypertension in multiple logistic regression analysis. Conclusion: Our findings recommend the constant monitoring of CHD risk factors and the formulation of effective preventive strategies for adequate control of alarming incidence

Community mobilisation with women's groups facilitated by Accredited Social Health Activists (ASHAs) to improve maternal and newborn health in underserved areas of Jharkhand and Orissa: study protocol for a cluster-randomised controlled trial

Background: Around a quarter of the world's neonatal and maternal deaths occur in India. Morbidity and mortality are highest in rural areas and among the poorest wealth quintiles. Few interventions to improve maternal and newborn health outcomes with government-mandated community health workers have been rigorously evaluated at scale in this setting.The study aims to assess the impact of a community mobilisation intervention with women's groups facilitated by ASHAs to improve maternal and newborn health outcomes among rural tribal communities of Jharkhand and Orissa.Methods/design: The study is a cluster-randomised controlled trial and will be implemented in five districts, three in Jharkhand and two in Orissa. The unit of randomisation is a rural cluster of approximately 5000 population. We identified villages within rural, tribal areas of five districts, approached them for participation in the study and enrolled them into 30 clusters, with approximately 10 ASHAs per cluster. Within each district, 6 clusters were randomly allocated to receive the community intervention or to the control group, resulting in 15 intervention and 15 control clusters. Randomisation was carried out in the presence of local stakeholders who selected the cluster numbers and allocated them to intervention or control using a pre-generated random number sequence. The intervention is a participatory learning and action cycle where ASHAs support community women's groups through a four-phase process in which they identify and prioritise local maternal and newborn health problems, implement strategies to address these and evaluate the result. The cycle is designed to fit with the ASHAs' mandate to mobilise communities for health and to complement their other tasks, including increasing institutional delivery rates and providing home visits to mothers and newborns. The trial's primary endpoint is neonatal mortality during 24 months of intervention. Additional endpoints include home care practices and health care-seeking in the antenatal, delivery and postnatal period. The impact of the intervention will be measured through a prospective surveillance system implemented by the project team, through which mothers will be interviewed around six weeks after delivery. Cost data and qualitative data are collected for cost-effectiveness and process evaluations

Explaining the impact of a women's group led community mobilisation intervention on maternal and newborn health outcomes: the Ekjut trial process evaluation

Background: Few large and rigorous evaluations of participatory interventions systematically describe their context and implementation, or attempt to explain the mechanisms behind their impact. This study reports process evaluation data from the Ekjut cluster-randomised controlled trial of a participatory learning and action cycle with women's groups to improve maternal and newborn health outcomes in Jharkhand and Orissa, eastern India (20052008). The study demonstrated a 45% reduction in neonatal mortality in the last two years of the intervention, largely driven by improvements in safe practices for home deliveries.Methods: A participatory learning and action cycle with 244 women's groups was implemented in 18 intervention clusters covering an estimated population of 114 141. We describe the context, content, and implementation of this intervention, identify potential mechanisms behind its impact, and report challenges experienced in the field. Methods included a review of intervention documents, qualitative structured discussions with group members and non-group members, meeting observations, as well as descriptive statistical analysis of data on meeting attendance, activities, and characteristics of group attendees.Results: Six broad, interrelated factors influenced the intervention's impact: (1) acceptability; (2) a participatory approach to the development of knowledge, skills and 'critical consciousness'; (3) community involvement beyond the groups; (4) a focus on marginalized communities; (5) the active recruitment of newly pregnant women into groups; (6) high population coverage. We hypothesize that these factors were responsible for the increase in safe delivery and care practices that led to the reduction in neonatal mortality demonstrated in the Ekjut trial.Conclusions: Participatory interventions with community groups can influence maternal and child health outcomes if key intervention characteristics are preserved and tailored to local contexts. Scaling-up such interventions requires (1) a detailed understanding of the way in which context affects the acceptability and delivery of the intervention; (2) planned but flexible replication of key content and implementation features; (3) strong support for participatory methods from implementing agencies

Genome Characterization of the Oleaginous Fungus Mortierella alpina

Mortierella alpina is an oleaginous fungus which can produce lipids accounting for up to 50% of its dry weight in the form of triacylglycerols. It is used commercially for the production of arachidonic acid. Using a combination of high throughput sequencing and lipid profiling, we have assembled the M. alpina genome, mapped its lipogenesis pathway and determined its major lipid species. The 38.38 Mb M. alpina genome shows a high degree of gene duplications. Approximately 50% of its 12,796 gene models, and 60% of genes in the predicted lipogenesis pathway, belong to multigene families. Notably, M. alpina has 18 lipase genes, of which 11 contain the class 2 lipase domain and may share a similar function. M. alpina's fatty acid synthase is a single polypeptide containing all of the catalytic domains required for fatty acid synthesis from acetyl-CoA and malonyl-CoA, whereas in many fungi this enzyme is comprised of two polypeptides. Major lipids were profiled to confirm the products predicted in the lipogenesis pathway. M. alpina produces a complex mixture of glycerolipids, glycerophospholipids and sphingolipids. In contrast, only two major sterol lipids, desmosterol and 24(28)-methylene-cholesterol, were detected. Phylogenetic analysis based on genes involved in lipid metabolism suggests that oleaginous fungi may have acquired their lipogenic capacity during evolution after the divergence of Ascomycota, Basidiomycota, Chytridiomycota and Mucoromycota. Our study provides the first draft genome and comprehensive lipid profile for M. alpina, and lays the foundation for possible genetic engineering of M. alpina to produce higher levels and diverse contents of dietary lipids

Search for gravitational waves associated with gamma-ray bursts detected by Fermi and Swift during the LIGO–Virgo run O3b

We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC–2020 March 27 17:00 UTC). We conduct two independent searches: a generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate

3D instability analysis of an underground geological repository-an Indian case study

Conceptual geological repositories are generally used for disposing spent nuclear wastes containing both high and low level of nuclear radiation and heat. Due to its long-lasting effect, it is imperative to analyze its long-term effect on the surrounding rock. Before analyzing radiation and thermal effect, it is important to have structurally stable cavern because designing an opening in rock is a more difficult problem than designing the structure made of steel. Underground rocks are under stress because of the weight of the overlying rock, and in addition, an underground opening will produce a stress concentration and stress relaxation in the surrounding rock. If the induced stress in the surrounding rock exceeds its strength, the opening will fail either by fracturing or by deforming more than the tolerable limit. In this paper, the stability of four different shapes of excavation has been examined for conceptual geological repositories in Indian context. This has been done using equivalent continuum numerical model which has been incorporated in the commercial finite difference code-FLAC-3D. Effects of opening shapes on stress distribution, subsidence of crown and side wall, and their stability have been analyzed and discussed. The validation of FLAC(3D) software for its applicability in conceptual underground geological repositories has been done with a published literature