33 research outputs found

    Deficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigation

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    Younger adults with anxiety disorders are known to show an attentional bias toward negative information. Little is known regarding the role of biased attention in anxious older adults, and even less is known about the neural substrates of any such bias. Functional magnetic resonance imaging (fMRI) was used to assess the mechanisms of attentional bias in late life by contrasting predictions of a top-down model emphasizing deficient prefrontal cortex (PFC) control and a bottom-up model emphasizing amygdalar hyperreactivity. In all, 16 older generalized anxiety disorder (GAD) patients (mean age=66 years) and 12 non-anxious controls (NACs; mean age=67 years) completed the emotional Stroop task to assess selective attention to negative words. Task-related fMRI data were concurrently acquired. Consistent with hypotheses, GAD participants were slower to identify the color of negative words relative to neutral, whereas NACs showed the opposite bias, responding more quickly to negative words. During negative words (in comparison with neutral), the NAC group showed PFC activations, coupled with deactivation of task-irrelevant emotional processing regions such as the amygdala and hippocampus. By contrast, GAD participants showed PFC decreases during negative words and no differences in amygdalar activity across word types. Across all participants, greater attentional bias toward negative words was correlated with decreased PFC recruitment. A significant positive correlation between attentional bias and amygdala activation was also present, but this relationship was mediated by PFC activity. These results are consistent with reduced prefrontal attentional control in late-life GAD. Strategies to enhance top-down attentional control may be particularly relevant in late-life GAD treatment

    The developmental pattern of stimulus and response interference in a color-object Stroop task: an ERP study

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    <p>Abstract</p> <p>Background</p> <p>Several studies have shown that Stroop interference is stronger in children than in adults. However, in a standard Stroop paradigm, stimulus interference and response interference are confounded. The purpose of the present study was to determine whether interference at the stimulus level and the response level are subject to distinct maturational patterns across childhood. Three groups of children (6–7 year-olds, 8–9 year-olds, and 10–12 year-olds) and a group of adults performed a manual Color-Object Stroop designed to disentangle stimulus interference and response interference. This was accomplished by comparing three trial types. In congruent (C) trials there was no interference. In stimulus incongruent (SI) trials there was only stimulus interference. In response incongruent (RI) trials there was stimulus interference and response interference. Stimulus interference and response interference were measured by a comparison of SI with C, and RI with SI trials, respectively. Event-related potentials (ERPs) were measured to study the temporal dynamics of these processes of interference.</p> <p>Results</p> <p>There was no behavioral evidence for stimulus interference in any of the groups, but in 6–7 year-old children ERPs in the SI condition in comparison with the C condition showed an occipital P1-reduction (80–140 ms) and a widely distributed amplitude enhancement of a negative component followed by an amplitude reduction of a positive component (400–560 ms). For response interference, all groups showed a comparable reaction time (RT) delay, but children made more errors than adults. ERPs in the RI condition in comparison with the SI condition showed an amplitude reduction of a positive component over lateral parietal (-occipital) sites in 10–12 year-olds and adults (300–540 ms), and a widely distributed amplitude enhancement of a positive component in all age groups (680–960 ms). The size of the enhancement correlated positively with the RT response interference effect.</p> <p>Conclusion</p> <p>Although processes of stimulus interference control as measured with the color-object Stroop task seem to reach mature levels relatively early in childhood (6–7 years), development of response interference control appears to continue into late adolescence as 10–12 year-olds were still more susceptible to errors of response interference than adults.</p

    Medical follow-up for workers exposed to bladder carcinogens: the French evidence-based and pragmatic statement

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    Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex

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    Can synchrotron micro-x-ray fluorescence spectroscopy be used to map the distribution of cadmium in soil particles?

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    Plants take up cadmium (Cd) from the soil, and the concentration of Cd in some plant products is a health concern. Plant uptake of Cd is poorly predicted by its concentration in soils; consequently, there is interest in the binding and distribution of Cd in soil. Synchrotron micro-X-ray fluorescence spectroscopy (micro-XRFS) is the most sensitive method of observing this distribution. We used beam-line 2-ID-D of the Advanced Photon Source (APS), Argonne, to test whether this technique could map the Cd distribution in 5 soils from Greater Sydney that contained 0.3-6.4 mg Cd/kg. A subsample of one soil was spiked to contain similar to 100 mg Cd/kg. Cadmium was readily mapped in the Cd-enriched subsample, whereas in the unamended soils, only one Cd-rich particle was found; that is, sensitivity generally limited Cd mapping. We also examined a sample of Nauru phosphorite, which was a primary source of much of the Cd in farm soils on the peri-urban fringe of Greater Sydney. The phosphorite contained similar to 100 mg Cd/kg and the Cd was relatively uniformly distributed, supporting the findings of an earlier study on an apatite from Africa. The micro-XRFS at beam-line 2-ID-D of the APS can be reconfigured to increase the sensitivity at least 10-fold, which may allow the distribution of Cd and its elemental associations to be mapped in particles of most agricultural soils and facilitate other spectroscopic investigations. © 2007, CSIRO Publishin
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