35 research outputs found
European survey on knowledge and attitudes of public health professionals on public health genomics: pilot study
Background: During the past decade a debate has arisen on the possible utility of genomic science for public health
purposes. Within this context, a survey is being conducted to assess attitudes of European public health (PH) professionals
belonging to European Public Health Association (EUPHA) network regarding their role in the implementation of public
health genomics (PHG), and their knowledge and attitudes regarding genetic testing and the delivery of genetic services.
Methods: A pilot on-line survey was conducted on professionals from Sapienza University of Rome and the Vrije
University of Amsterdam. The survey tool is composed of 5 sections: Personal details, Professional activity, Knowledge
on genetic testing and delivery of genetic services, Attitudes on genetic testing and delivery of genetic services,
Attitudes on the role of PH professionals in PHG.
Results: 34 people responded to the questionnaire, mostly medical doctors (61.8%). No respondents correctly identified all
evidence-based applications of genetic testing. More than one third of respondents agreed that it would be more important
to invest resources in the social and environmental causes of ill health than in genetic testing. Nearly 70% thought that PHG
needs to be grounded on evidence of effectiveness, a lower rate agreed ii should be grounded on cost-effectiveness. The
rate of agreement with the proposed roles of PH professionals in PHG was very high.
Conclusion: This pilot study showed a positive attitude but the need to improve knowledge of PH professionals on
PHG. It provided useful input for the implementation of the survey to all members of the EUPHA network
An Italian survey on the attitudes and beliefs of public health professionals towards mandatory vaccination: a pilot stud
Background: This pilot study aimed to test a questionnaire developed to assess the attitudes and beliefs of Italian public health professionals towards mandatory vaccination for school-aged children.
Methods: The online questionnaire was administered to members of the Italian Society of Hygiene, Preventive Medicine and Public Health. Internal consistency was measured using Cronbach’s alpha.
Results: Fifty-two people answered the questionnaire: 90.4% were in favour of mandatory vaccination. Overall, the alpha score was above the cut-off value of 0.70.
Conclusion: The questionnaire has proved a valid tool for assessing the attitudes and beliefs of Italian public health professionals towards mandatory vaccination
Identification of delivery models for the provision of predictive genetic testing in Europe: protocol for a multicentre qualitative study and a systematic review of the literature
Introduction: The appropriate application of genomic technologies in healthcare is surrounded by many concerns. In particular, there is a lack of evidence on what constitutes an optimal genetic service delivery model, which depends on the type of genetic test and healthcare context considered. The present project aims to identify, classify, and evaluate delivery models for the provision of predictive genetic testing in Europe and in selected Anglophone extra-European countries (the USA, Canada, Australia, and New Zealand). It also sets out to survey the European public health community’s readiness to incorporate public health genomics into their practice.
Materials and equipment: The project consists of (i) a systematic review of published literature and selected country websites, (ii) structured interviews with health experts on the genetic service delivery models in their respective countries, and (iii) a survey of European Public Health Association (EUPHA) members’ knowledge and attitudes toward genomics applications in clinical practice. The inclusion criteria for the systematic review are that articles be published in the period 2000–2015; be in English or Italian; and be from European countries or from Canada, the USA, Australia, or New Zealand. Additional policy documents will be retrieved from represented countries’ government-affiliated websites. The results of the research will be disseminated through the EUPHA network, the Italian Network for Genomics in Public Health (GENISAP), and seminars and workshops.
Expected impact of the study on public health: The transfer of genomic technologies from research to clinical application is influenced not only by several factors inherent to research goals and delivery of healthcare but also by external and commercial interests that may cause the premature introduction of genetic tests in the public and private sectors. Furthermore, current genetic services are delivered without a standardized set of process and outcome measures, which makes the evaluation of healthcare services difficult. The present study will identify and classify delivery models and, subsequently, establish which are appropriate for the provision of predictive genetic testing in Europe by comparing sets of process and outcome measures. In this way, the study will provide a basis for future recommendations to decision makers involved in the financing, delivery, and consumption of genetic services
Which BRCA genetic testing programs are ready for implementation in health care? A systematic review of economic evaluations
Purpose: There is considerable evidence regarding the efficacy and effectiveness of BRCA genetic testing programs, but whether they represent good use of financial resources is not clear. Therefore, we aimed to identify the main health-care programs for BRCA testing and to evaluate their cost-effectiveness.
Methods: We performed a systematic review of full economic evaluations of health-care programs involving BRCA testing.
Results: Nine economic evaluations were included, and four main categories of BRCA testing programs were identified: (i) populationbased genetic screening of individuals without cancer, either comprehensive or targeted based on ancestry; (ii) family history (FH)-based genetic screening, i.e., testing individuals without cancer but with FH suggestive of BRCA mutation; (iii) familial mutation (FM)- based genetic screening, i.e., testing individuals without cancer but with known familial BRCA mutation; and (iv) cancer-based genetic screening, i.e., testing individuals with BRCA-related cancers.
Conclusions: Currently BRCA1/2 population-based screening represents good value for the money among Ashkenazi Jews only. FHbased screening is potentially very cost-effective, although further studies that include costs of identifying high-risk women are needed. There is no evidence of cost-effectiveness for BRCA screening of all newly diagnosed cases of breast/ovarian cancers followed by cascade testing of relatives, but programs that include tools for identifying affected women at higher risk for inherited forms are promising. Cost-effectiveness is highly sensitive to the cost of BRCA1/2 testing
Public health genomics research in Italy: an overview of ongoing projects
Public health genomics (PHG) aims to integrate advances in genomic sciences into healthcare for the benefit of the general population. As in many countries, there are various research initiatives in this field in Italy, but a clear picture of the national research portfolio has never been sketched. Thus, we aimed to provide an overview of current PHG research projects at the national or international level by consultation with Italian institutional and academic experts. We included 68 PHG projects: the majority were international projects in which Italian researchers participated (n = 43), mainly funded by the European Commission, while the remainder were national initiatives (N = 25), mainly funded by central government. Funding varied considerably, from € 50,000 to € 80,803,177. Three main research themes were identified: governance (N = 20); precision medicine (PM; N = 46); and precision public health (N = 2). We found that research activities are preferentially aimed at the clinical application of PM, while other efforts deal with the governance of the complex translation of genomic innovation into clinical and public health practice. To align such activities with national and international priorities, the development of an updated research agenda for PHG is needed
Value-based genomic screening: exploring genomic screening for chronic diseases using triple value principles
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How is genetic testing evaluated? A systematic review of the literature
open8Given the rapid development of genetic tests, an assessment of their benefits, risks, and limitations is crucial for public health practice. We performed a systematic review aimed at identifying and comparing the existing evaluation frameworks for genetic tests. We searched PUBMED, SCOPUS, ISI Web of Knowledge, Google Scholar, Google, and gray literature sources for any documents describing such frameworks. We identified 29 evaluation frameworks published between 2000 and 2017, mostly based on the ACCE Framework (n = 13 models), or on the HTA process (n = 6), or both (n = 2). Others refer to the Wilson and Jungner screening criteria (n = 3) or to a mixture of different criteria (n = 5). Due to the widespread use of the ACCE Framework, the most frequently used evaluation criteria are analytic and clinical validity, clinical utility and ethical, legal and social implications. Less attention is given to the context of implementation. An economic dimension is always considered, but not in great detail. Consideration of delivery models, organizational aspects, and consumer viewpoint is often lacking. A deeper analysis of such context-related evaluation dimensions may strengthen a comprehensive evaluation of genetic tests and support the decision-making process.openPitini, Erica*; de Vito, Corrado; Marzuillo, Carolina; D’Andrea, Elvira; Rosso, Annalisa; Federici, Antonio; Di Maria, Emilio; Villari, PaoloPitini, Erica; de Vito, Corrado; Marzuillo, Carolina; D’Andrea, Elvira; Rosso, Annalisa; Federici, Antonio; Di Maria, Emilio; Villari, Paol
The development of strategies to contrast vaccine hesitancy in Italy
Background. The extension of compulsory vaccination, introduced by law in 2017 in Italy, may not be sufficient to guarantee the compliance with immunization coverage in the long term. The aim of this research project is to assess knowledge and attitudes on vaccinations and on mandatory immunization in different populations (pregnant women, midwives, public health professionals), in order to support the development of tailored strategies to contrast vaccine hesitancy in the Country.
Methods. We conducted a cross-sectional survey on a sample of pregnant women attending antenatal classes (CANs) in Rome through distribution of a self-administered questionnaire. Multiple logistic regression models were built to analyze the determinants of knowledge, attitudes and intention to vaccinate in this population. An online survey to identify level and determinants of knowledge and attitudes about vaccinations of midwives members of the professional register of Rome is currently ongoing, while a survey aimed at addressing the attitudes of Italian Public Health (PH) professionals on mandatory
vaccinations is under development.
Results. A total of 458 pregnant women attending CANs in 36 family health centers and two hospitals in Rome answered the survey. More than 26% of respondents showed a good level of knowledge of the safety and efficacy of vaccines, but there were high rates of uncertainty or agreement with some of the most common anti-vaccination thesis. Only 75% of women were sure about vaccinating their children with the hexavalent vaccine, and 64.3% with MMR. A good level of knowledge was the strongest predictor of positive attitudes towards vaccination (OR 11.61, 95% CI 6.43-20.96), which, in turn, influenced
the intention to vaccinate for most vaccines, together with the perception of the benefit of immunization. Preliminary results on data collected from 87 midwives show a heterogeneous level of knowledge in this population: only 62% respondents were certain of the safety of multiple shots at the same time, while 24% agreed that three-month-old children are too young to begin the immunization schedule.
Conclusions. Scepticism about the safety, efficacy and importance of vaccines is associated to pregnant women’s hesitancy on vaccinations, suggesting the need to develop strategies to increase vaccine acceptance in the antenatal period. Based on the results of the two surveys, we will focus on increasing the capacity of HCWs working in the antenatal setting, particularly midwives and nurses, to correctly deliver information to future parents. The results of the survey addressed at PH professionals will allow evaluating the impact of the mandatory vaccination policy on the PH services in the Country